Výsledky vyhledávání - "Prashant raj Bhattarai"

CD117 Antibody Drug Conjugate-Based Conditioning Enables Efficient Engraftment of Gene-Modified CD34+ Cells in a Rhesus Gene Therapy Model

Autor: Rahul Palchaudhuri, Naoya Uchida, Ulana Stasula, Malikiya Hinds, Paula Germino-Watnick, Allen E Krouse, Nathaniel Linde, Aylin Bonifacino, Kellie Latimer, Prashant raj Bhattarai, Nicholas C Yoder, Qing Li, Kirk Bertelsen, Lisa M Olson, Robert E. Donahue, John F. Tisdale

Publikováno v: Transplantation and Cellular Therapy. 28:S238

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::11e14642961526cbef650f0cabc2a9f0
https://doi.org/10.1016/s2666-6367(22)00465-1

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Single Agent CD117-Targeted Antibody Drug Conjugate in Combination with Lymphodepleting Antibodies Enables Allogenic Hematopoietic Stem Cell Transplantation in Mice without Chemotherapy or Radiation

Autor: Tahirih L. Lamothe, Lisa M Olson, Leanne Lanieri, Prashant raj Bhattarai, Rahul Palchaudhuri

Publikováno v: Blood. 138:1682-1682

Hematopoietic stem cell transplant (HSCT) is a highly effective and potentially curative treatment for malignant and non-malignant blood disorders. However, patient eligibility for this procedure can be limited due to the mortality and morbidity risk

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd776b3dd0892e20f593dffaf417e4de
https://doi.org/10.1182/blood-2021-147905

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A Single Dose of a Novel Anti-Human CD117-Amanitin Antibody Drug Conjugate (ADC) Engineered for a Short Half-Life Provides Dual Conditioning and Anti-Leukemia Activity and Extends Survival Compared to Standard of Care in Multiple Preclinical Models of Acute Myeloid Leukemia (AML)

Autor: Oliver Mikse, Tahirih L. Lamothe, Lisa M Olson, Nidhi Jain, Jennifer L. Proctor, Ryan Knihtila, Sean McDonough, John C. Davis, Anthony E. Boitano, Rahul Palchaudhuri, Michael P. Cooke, Ganapathy N. Sarma, Bradley R. Pearse, Prashant raj Bhattarai, Leanne Lanieri, Junia Dushime, Kellie Latimer

Publikováno v: Transplantation and Cellular Therapy. 27:S49-S50

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1be6db879b36491aaefce34d13b1d033
https://doi.org/10.1016/s2666-6367(21)00079-8

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A Single Dose of a Novel Anti-Human CD117-Amanitin Antibody Drug Conjugate (ADC) Engineered for a Short Half-Life Provides Dual Conditioning and Anti-Leukemic Activity and Extends Survival Compared to Standard of Care in Multiple Preclinical Models of Acute Myeloid Leukemia (AML)

Autor: Ryan Knihtila, Michael P. Cooke, Tahirih L. Lamothe, Leanne Lanieri, Sean McDonough, Anthony E. Boitano, Prashant raj Bhattarai, John C. Davis, Rahul Palchaudhuri, Junia Dushime, Jennifer L. Proctor, Oliver Miske, Nidhi Jain, Ganapathy N. Sarma, Bradley R. Pearse, Kellie Latimer

Publikováno v: Blood. 136:47-48

Hematopoietic stem cell transplant (HSCT) can be a highly effective, and often curative, treatment for patients with AML. At present, myeloablative conditioning (MAC) regimens are associated with severe acute and long-term toxicities. A subset of tra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7ff725b3a25ef027eac59dbe5dd4c3b7
https://doi.org/10.1182/blood-2020-140422

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A Single Dose of a Novel Anti-Human Short Half-Life Engineered CD45-Targeted Antibody-Drug Conjugate (ADC) Is Cytoreductive on Patient-Derived Tumors and Extends Survival Beyond Standards of Care in Multiple Pre-Clinical Models of Hematologic Malignancy

Autor: Tahirih L. Lamothe, Sean McDonough, Prashant raj Bhattarai, Oliver Mikse, Michael P. Cooke, Anthony E. Boitano, Rahul Palchaudhuri, Melissa L. Brooks, Ganapathy N. Sarma, Jennifer L. Proctor, Charlotte Mcdonagh, Geoffrey O. Gillard, Leanne Lanieri, Nidhi Jain, Lena Kien, Anjali Bhat

Publikováno v: Biology of Blood and Marrow Transplantation. 26:S96

For patients with refractory or high-risk hematologic malignancies, like acute myeloid leukemia (AML), myelodysplastic syndromes (MDS), and acute lymphoblastic leukemia (ALL), allogeneic hematopoietic stem cell transplant (Allo-HSCT) is a potentially

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9610c77dbce618ed391130a813ecff5d
https://doi.org/10.1016/j.bbmt.2019.12.021

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A Novel Targeted Approach to Achieve Immune System Reset: CD45-Targeted Antibody Drug Conjugates Enable Autologous HSCT, Ameliorate Disease in Autoimmune Models, Potently Kill Human Immune Cells from Normal Donors and MS Patients, and Achieve Immune Depletion in Non-Human Primates (NHP)

Autor: Anjali Bhat, Michael P. Cooke, Oliver Mikse, Prashant raj Bhattarai, Charlotte F. Mcdonough, Geoff O Gillard, Tahirih L. Lamothe, Sharon L. Hyzy, Rahul Palchaudhuri, Ganapathy N. Sarma, Bradley R. Pearse, Jennifer L. Proctor, Anthony E. Boitano, Sean McDonough, Melissa L. Brooks, Pranoti Sawant

Publikováno v: Blood. 134:3208-3208

Resetting the immune system through autologous hematopoietic stem cell transplant (autoHSCT) is a highly effective treatment in selected patients with autoimmune diseases. AutoHSCT can induce long-term remission (up to 15 years) with 70-80% progressi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aecdbfde49cb22e4f04e4e59a05ec5a1
https://doi.org/10.1182/blood-2019-130752

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