Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Prashant R, Nambiar"'
Autor:
Prashant R Nambiar, Nicole A Protheroe, Kelly DellaGrotte, Harini Kantamneni, Sumati Sundaram, Scott F Heller, Christina Ferren, Collin Walter, Corinne Decker, Alison Crawford, Tina Chang Albershardt
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/b0fd247e17bd462799e3a3d712c32190
Autor:
Daniel Sommermeyer, Christian Ellinger, Giulia Longinotti, Dolores J Schendel, Michael S Magee, Kathrin Davari, Tristan Holland, Laura Prassmayer, Iulia Diaconu, Kenneth P Ganley, Lisa J Pechilis, Prashant R Nambiar
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 3 (2021)
Background The cancer-testis antigen MAGE-A4 is an attractive target for T-cell-based immunotherapy, especially for indications with unmet clinical need like non-small cell lung or triple-negative breast cancer.Methods An unbiased CD137-based sorting
Externí odkaz:
https://doaj.org/article/6790f2555dec4bc39ad9b227b670bd0f
Autor:
Iulia Diaconu, Tristan Holland, Lisa J Pechilis, Kenneth P Ganley, Daniel Sommermeyer, Kathrin Davari, Giulia Longinotti, Prashant R Nambiar, Laura Prassmayer, Dolores J. Schendel, Christian Ellinger, Michael S. Magee
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 3 (2021)
Journal for Immunotherapy of Cancer
Journal for Immunotherapy of Cancer
Background The cancer-testis antigen MAGE-A4 is an attractive target for T cell-based immunotherapy, especially for indications with unmet clinical need like non-small-cell lung carcinoma or triple-negative breast cancer. Overcoming high tumor burden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::061c0eceb4fa27f9d2cd8820847f7256
https://doi.org/10.1136/jitc-2020-002035
https://doi.org/10.1136/jitc-2020-002035
Autor:
Zaher A. Radi, W. Mark Vogel, Petra H. Koza-Taylor, Alexandros Papanikolaou, Phillip M. Bartholomew, Douglas J. Ball, Prashant R. Nambiar, Todd Wisialowski
Publikováno v:
Regulatory toxicology and pharmacology : RTP. 91
Tofacitinib is an oral JAK inhibitor for the treatment of rheumatoid arthritis. In the 2-year carcinogenicity study with tofacitinib, increased incidence of hibernoma (a neoplasm of brown adipose tissue [BAT]) was noted in female rats at ≥30 mg/kg/
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eeb4d7c6a0bf9722dd5f49b1b7128b7d
https://pubmed.ncbi.nlm.nih.gov/29074274
https://pubmed.ncbi.nlm.nih.gov/29074274
Autor:
Gwendolyn D. Fate, Gregory L. Finch, Steven Bailey, Daniel Morton, Peter J. Thomford, Christopher Houle, Prashant R. Nambiar, Leland Wayne Dochterman
Publikováno v:
Toxicologic Pathology. 43:354-365
Administration of lersivirine, a nonnucleotide reverse transcriptase inhibitor, daily by oral gavage to Sprague-Dawley rats for up to 2 yr was associated with decreased survival, decreased body weights, and an increase in neoplasms and related prolif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96e381add7cf3eecdcaeee1e9b43a2d9
https://doi.org/10.1177/0192623314544381
https://doi.org/10.1177/0192623314544381
Autor:
Frank D. Sistare, Nancy Bower, Zaher A. Radi, Oliver C. Turner, Daniel Morton, Prashant R. Nambiar
Publikováno v:
Toxicologic Pathology. 42:799-806
International regulatory and pharmaceutical industry scientists are discussing revision of the International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) S1 guidance on rodent carcinoge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f6f27d3363f2386a3ed8ee3898ce307
https://doi.org/10.1177/0192623313502130
https://doi.org/10.1177/0192623313502130
Autor:
Daniel Morton, Prashant R. Nambiar
Publikováno v:
Toxicologic Pathology. 41:1058-1067
A factor limiting widespread use of the transgenic rasH2 mouse model for carcinogenicity testing of pharmaceuticals is the paucity of published data on actual drug candidates in rasH2 mice. This report addresses this gap by highlighting rasH2 mouse s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6dd8c8fa8720a7d3276527bd2e124e4
https://doi.org/10.1177/0192623313477257
https://doi.org/10.1177/0192623313477257
Publikováno v:
Toxicologic Pathology. 40:614-623
Alternate transgenic mouse models are accepted as replacements for the standard carcinogenicity mouse bioassay by regulatory agencies with a companion 2-year rat bioassay. The slower rate of industry acceptance of these shorter transgenic mouse cance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d3d3ec6ad5d37026a420a5c0e65d737
https://doi.org/10.1177/0192623311436181
https://doi.org/10.1177/0192623311436181
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 693:3-18
Despite an increased understanding of the molecular pathogenesis of colorectal cancer (CRC) during the past two decades, reliable and robust biomarkers to enable screening, surveillance, and primary prevention of this disease are lacking. CRC diagnos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e37e6b6c75c0ab9be407ecc3b8056c4
https://doi.org/10.1016/j.mrfmmm.2010.07.008
https://doi.org/10.1016/j.mrfmmm.2010.07.008
Publikováno v:
Journal of Medical Primatology. 38:377-381
Background Seizures were observed in a 16-year old male Guyanese squirrel monkey with a history of inappetence and weakness. Methods and results Complete blood count, biochemical profile, and urinalysis indicated systemic disease. Nematode larvae wer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dda2538023bd2aea516dd3ea287e44fe
https://doi.org/10.1111/j.1600-0684.2009.00363.x
https://doi.org/10.1111/j.1600-0684.2009.00363.x