Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Prashant Nighot"'
Autor:
Ashwinkumar Subramenium Ganapathy, Kushal Saha, Alexandra Wang, Priya Arumugam, Viszwapriya Dharmaprakash, Gregory Yochum, Walter Koltun, Meghali Nighot, Gary Perdew, Todd A. Thompson, Thomas Ma, Prashant Nighot
Publikováno v:
Cell Reports, Vol 42, Iss 7, Pp 112705- (2023)
Summary: Defects in intestinal epithelial tight junctions (TJs) allow paracellular permeation of noxious luminal antigens and are important pathogenic factors in inflammatory bowel disease (IBD). We show that alpha-tocopherylquinone (TQ), a quinone-s
Externí odkaz:
https://doaj.org/article/e5922946dedf43da84dd39a1f3b8b459
Autor:
Rana Al-Sadi, Viszwapriya Dharmaprakash, Prashant Nighot, Shuhong Guo, Meghali Nighot, Toan Do, Thomas Y. Ma
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 15, p 8070 (2021)
Defective intestinal tight junction (TJ) barrier is a hallmark in the pathogenesis of inflammatory bowel disease (IBD). To date, there are no effective therapies that specifically target the intestinal TJ barrier. Among the various probiotic bacteria
Externí odkaz:
https://doaj.org/article/33a7fb3b09174925bf41e44493371cdf
Autor:
Victoria A. Meliopoulos, Shauna A. Marvin, Pamela Freiden, Lindsey A. Moser, Prashant Nighot, Rizwana Ali, Anthony Blikslager, Muralidhar Reddivari, Richard J. Heath, Matthew D. Koci, Stacey Schultz-Cherry
Publikováno v:
mBio, Vol 7, Iss 6 (2016)
ABSTRACT The disease mechanisms associated with the onset of astrovirus diarrhea are unknown. Unlike other enteric virus infections, astrovirus infection is not associated with an inflammatory response or cellular damage. In vitro studies in differen
Externí odkaz:
https://doaj.org/article/eea64f2f4c4548f188b74334aaaa9837
Autor:
Kushal Saha, Ashwinkumar Subramenium Ganapathy, Alexandra Wang, Nathan Michael Morris, Eric Suchanec, Wei Ding, Gregory Yochum, Walter Koltun, Meghali Nighot, Thomas Ma, Prashant Nighot
Publikováno v:
Journal of Crohn'scolitis.
Background and Aims Functional loss of the gut epithelium’s paracellular tight junction [TJ] barrier and defective autophagy are factors potentiating inflammatory bowel disease [IBD]. Previously, we showed the role of autophagy in enhancing the int
Autor:
Meghali Nighot, Manmeet Rawat, Rana Al-Sadi, Thomas Y. Ma, Mohammad Rashedul Haque, Prashant Nighot
Publikováno v:
Am J Pathol
Defective intestinal tight junction (TJ) barrier is an important pathogenic factor of inflammatory bowel disease. To date, no effective therapies that specifically target the intestinal TJ barrier are available. The purpose of this study was to ident
Autor:
Meghali Nighot, Pei-Luan Liao, Nathan Morris, Dennis McCarthy, Viszwapriya Dharmaprakash, Inam Ullah Khan, Shannon Dalessio, Kushal Saha, Ashwinkumar Subramaniam Ganapathy, Alexandra Wang, Wei Ding, Gregory Yochum, Walter Koltun, Prashant Nighot, Thomas Ma
Publikováno v:
Journal of Crohn'scolitis.
Background Proton pump inhibitors [PPIs] are widely used to treat a number of gastro-oesophageal disorders. PPI-induced elevation in intragastric pH may alter gastrointestinal physiology. The tight junctions [TJs] residing at the apical intercellular
Autor:
Kushal Saha, Ashwinkumar Subramenium Ganapathy, Alexandria Wang, Nathan Michael Morris, Eric Suchanec, Gregory Yochum, Walter Koltun, Wei Ding, Meghali Nighot, Thomas Ma, Prashant Nighot
Background and AimFunctional loss of paracellular tight junction (TJ) barrier of the gut epithelium and mutations in autophagy genes are factors potentiating inflammatory bowel disease (IBD). Previously we showed the role of autophagy in enhancing th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32aeddd501c1ff4eee3e906f0ae1fbd0
https://doi.org/10.1101/2022.04.11.487876
https://doi.org/10.1101/2022.04.11.487876
Autor:
Ashwinkumar Subramenium Ganapathy, Kushal Saha, Eric Suchanec, Vikash Singh, Aayush Verma, Gregory Yochum, Walter Koltun, Meghali Nighot, Thomas Ma, Prashant Nighot
Publikováno v:
Autophagy
The intestinal epithelial tight junctions (TJs) provide barrier against paracellular permeation of lumenal antigens. Defects in TJ barrier such as increased levels of pore-forming TJ protein CLDN2 (claudin-2) is associated with inflammatory bowel dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eab7944c2300e82e199bc313a259347c
https://europepmc.org/articles/PMC9466623/
https://europepmc.org/articles/PMC9466623/
Autor:
Thomas Y. Ma, Prashant Nighot
Publikováno v:
Inflamm Bowel Dis
Eukaryotic cells take up macromolecules and particles from the surrounding milieu and also internalize membrane proteins via a precise process of endocytosis. The role of endocytosis in diverse physiological processes such as cell adhesion, cell sign
Autor:
Steven D. Shapiro, Thomas Y. Ma, Prashant Nighot, Meghali Nighot, Alyssa D. Gregory, Eric Suchanec, Kushal Saha, Eliseo F. Castillo, Ashwinkumar Subramenium Ganapathy
Publikováno v:
J Crohns Colitis
Background and Aims Matrix metalloproteinases [MMPs] play an important role in extracellular matrix regulation during cell growth and wound healing. Increased expression of MMP-12 [human macrophage elastase] has been reported in inflammatory bowel di