Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Prashant Monian"'
Autor:
Neal Rosen, Sarat Chandarlapaty, Ningshu Liu, José Baselga, Elisa de Stanchina, Xuejun Jiang, Prashant Monian, Xiaodong Huang, Claudia Schneider, Vanessa Rodrik-Outmezguine, Zhan Yao, Weiyi Toy, Alice Can Ran Qin, Marie Will
The effects of selective phosphoinositide 3-kinase (PI3K) and AKT inhibitors were compared in human tumor cell lines in which the pathway is dysregulated. Both caused inhibition of AKT, relief of feedback inhibition of receptor tyrosine kinases, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91cb145c784d87d6d9bae733b069e129
https://doi.org/10.1158/2159-8290.c.6546140.v1
https://doi.org/10.1158/2159-8290.c.6546140.v1
Autor:
Neal Rosen, Sarat Chandarlapaty, Ningshu Liu, José Baselga, Elisa de Stanchina, Xuejun Jiang, Prashant Monian, Xiaodong Huang, Claudia Schneider, Vanessa Rodrik-Outmezguine, Zhan Yao, Weiyi Toy, Alice Can Ran Qin, Marie Will
PDF file 93K, This file contains detailed description of experimental procedures as well as reagents utilized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70381ca067d022a4465da17df9906051
https://doi.org/10.1158/2159-8290.22530248
https://doi.org/10.1158/2159-8290.22530248
Autor:
Neal Rosen, Sarat Chandarlapaty, Ningshu Liu, José Baselga, Elisa de Stanchina, Xuejun Jiang, Prashant Monian, Xiaodong Huang, Claudia Schneider, Vanessa Rodrik-Outmezguine, Zhan Yao, Weiyi Toy, Alice Can Ran Qin, Marie Will
PDF file 40K, Supplementary Figure S6. Induction of apoptosis by PI3K inhibition in HER2-amplified cells. Related to main Figure 6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0aeddd3a726f9efcced02e8eb21b7348
https://doi.org/10.1158/2159-8290.22530254.v1
https://doi.org/10.1158/2159-8290.22530254.v1
Autor:
Neal Rosen, Sarat Chandarlapaty, Ningshu Liu, José Baselga, Elisa de Stanchina, Xuejun Jiang, Prashant Monian, Xiaodong Huang, Claudia Schneider, Vanessa Rodrik-Outmezguine, Zhan Yao, Weiyi Toy, Alice Can Ran Qin, Marie Will
PDF file 2251K, Supplementary Figure S2. PI3K, but not AKT or mTOR, is upstream of the ERK signaling pathway. Related to main Figure 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bc6e296caa4e4d18577b588841b26d1
https://doi.org/10.1158/2159-8290.22530266
https://doi.org/10.1158/2159-8290.22530266
Autor:
Neal Rosen, Sarat Chandarlapaty, Ningshu Liu, José Baselga, Elisa de Stanchina, Xuejun Jiang, Prashant Monian, Xiaodong Huang, Claudia Schneider, Vanessa Rodrik-Outmezguine, Zhan Yao, Weiyi Toy, Alice Can Ran Qin, Marie Will
PDF file 783K, Supplementary Figure S4. PI3K inhibition does not decrease P-ERK in RAS-mutant cells. Related to main Figure 4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b4d26373ec17aa44e20b765afb4ad23
https://doi.org/10.1158/2159-8290.22530260.v1
https://doi.org/10.1158/2159-8290.22530260.v1
Autor:
Neal Rosen, Sarat Chandarlapaty, Ningshu Liu, José Baselga, Elisa de Stanchina, Xuejun Jiang, Prashant Monian, Xiaodong Huang, Claudia Schneider, Vanessa Rodrik-Outmezguine, Zhan Yao, Weiyi Toy, Alice Can Ran Qin, Marie Will
PDF file 67K, This file contains legends for supplementary figures S1-S7. It describes in detail what's included in each figure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16a3c21a423d8dde0c3d881a1d16e6f0
https://doi.org/10.1158/2159-8290.22530272
https://doi.org/10.1158/2159-8290.22530272
Autor:
Neal Rosen, Sarat Chandarlapaty, Ningshu Liu, José Baselga, Elisa de Stanchina, Xuejun Jiang, Prashant Monian, Xiaodong Huang, Claudia Schneider, Vanessa Rodrik-Outmezguine, Zhan Yao, Weiyi Toy, Alice Can Ran Qin, Marie Will
PDF file 67K, This file contains legends for supplementary figures S1-S7. It describes in detail what's included in each figure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41e3ead32ebc7de0f8d64eff953ed29a
https://doi.org/10.1158/2159-8290.22530272.v1
https://doi.org/10.1158/2159-8290.22530272.v1
Autor:
Neal Rosen, Sarat Chandarlapaty, Ningshu Liu, José Baselga, Elisa de Stanchina, Xuejun Jiang, Prashant Monian, Xiaodong Huang, Claudia Schneider, Vanessa Rodrik-Outmezguine, Zhan Yao, Weiyi Toy, Alice Can Ran Qin, Marie Will
PDF file 1177K, Supplementary Figure S5. PI3K regulates the level of active RAS in RAS wild type cells. Related to main Figure 5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a0357dcdd304d2530519a7197cc3b36
https://doi.org/10.1158/2159-8290.22530257
https://doi.org/10.1158/2159-8290.22530257
Autor:
Neal Rosen, Sarat Chandarlapaty, Ningshu Liu, José Baselga, Elisa de Stanchina, Xuejun Jiang, Prashant Monian, Xiaodong Huang, Claudia Schneider, Vanessa Rodrik-Outmezguine, Zhan Yao, Weiyi Toy, Alice Can Ran Qin, Marie Will
PDF file 778K, Supplementary Figure S3. Pan PI3K inhibitor GDC-0941 downregulates ERK phosphorylation. Related to main Figure 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::189b658e54f85309771c87982a5e4989
https://doi.org/10.1158/2159-8290.22530263.v1
https://doi.org/10.1158/2159-8290.22530263.v1
Autor:
Neal Rosen, Sarat Chandarlapaty, Ningshu Liu, José Baselga, Elisa de Stanchina, Xuejun Jiang, Prashant Monian, Xiaodong Huang, Claudia Schneider, Vanessa Rodrik-Outmezguine, Zhan Yao, Weiyi Toy, Alice Can Ran Qin, Marie Will
PDF file 3213K, Figure S1. BAY 80-6946 is a potent and selective PI3K inhibitor. PI3K inhibition induces more apoptosis than AKT inhibition. Related to main Figure 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d40793ebc4f03154d0c1a8d2382cee9
https://doi.org/10.1158/2159-8290.22530269
https://doi.org/10.1158/2159-8290.22530269