Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Prashant K, Singh"'
Autor:
Saeed Daneshmandi, Jee Eun Choi, Qi Yan, Cameron R. MacDonald, Manu Pandey, Mounika Goruganthu, Nathan Roberts, Prashant K. Singh, Richard M. Higashi, Andrew N. Lane, Teresa W-M. Fan, Jianmin Wang, Philip L. McCarthy, Elizabeth A. Repasky, Hemn Mohammadpour
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Myeloid derived suppressor cells (MDSCs) are key regulators of immune responses and correlate with poor outcomes in hematologic malignancies. Here, we identify that MDSC mitochondrial fitness controls the efficacy of doxorubicin chemotherapy
Externí odkaz:
https://doaj.org/article/38460ce622de479f9a32204e95da4901
Autor:
Chetan C. Oturkar, Spencer R. Rosario, Alan D. Hutson, Adrianne Groman, Stephen B. Edge, Carl D. Morrison, Wendy M. Swetzig, Jianmin Wang, Jun Hyoung Park, Benny Abraham Kaipparettu, Prashant K. Singh, Shicha Kumar, Helen H. Cappuccino, Manish Ranjan, Araba Adjei, Mohammad Ghasemi, Andrew K.L. Goey, Swati Kulkarni, Gokul M. Das
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109995- (2024)
Summary: The canonical mechanism behind tamoxifen’s therapeutic effect on estrogen receptor α/ESR1+ breast cancers is inhibition of ESR1-dependent estrogen signaling. Although ESR1+ tumors expressing wild-type p53 were reported to be more responsi
Externí odkaz:
https://doaj.org/article/04d36b95d2554e01bb9488680b2e7511
Autor:
Anna Mistarz, Marta Winkler, Sebastiano Battaglia, Song Liu, Alan Hutson, Hanna Rokita, Andrea Gambotto, Kunle O. Odunsi, Prashant K. Singh, A.J. Robert McGray, Jianmin Wang, Danuta Kozbor
Publikováno v:
Molecular Therapy: Oncolytics, Vol 28, Iss , Pp 230-248 (2023)
Tumor antigen-driven responses to weakly immunogenic self-antigens and neoantigens directly affect treatment efficacy following immunotherapy. Using orthotopically grown SV40 T antigen+ ovarian carcinoma in antigen-naive wild-type or TgMISIIR-TAg-Low
Externí odkaz:
https://doaj.org/article/8e193af5311646bdb302dc5359bacd3f
Autor:
Varsha K. Singh, Sapana Jha, Palak Rana, Renu Soni, Rowland Lalnunpuii, Prashant K. Singh, Rajeshwar P. Sinha, Garvita Singh
Publikováno v:
Energies, Vol 17, Iss 2, p 408 (2024)
The combustion of fossil fuels constitutes a significant catalyst for climate change, resulting in the annual release of about two billion tonnes of carbon dioxide (CO2). The increase in CO2 emission is directly linked to a heightened occurrence of n
Externí odkaz:
https://doaj.org/article/2af4543781d440358b04117171b4ecda
Autor:
Prashant K. Singh, Parvin Varmazyar, Bence Nagy, Joon-Gon Son, Sargis Ter-Avetisyan, Karoly Osvay
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-8 (2022)
Abstract Spatial characterization of 0.5 MeV proton beam, driven by 12 fs, 35 mJ, 1019 W/cm2 intense laser-foil interaction is presented. The accelerated proton beam has been applied to obtain a high-resolution, point-projection static radiograph of
Externí odkaz:
https://doaj.org/article/3658f31a93be4cb291eed0cd9c5a1f9b
Publikováno v:
PLoS ONE, Vol 18, Iss 5, p e0285343 (2023)
The flagellar motor supports bacterial chemotaxis, a process that allows bacteria to move in response to their environment. A central feature of this motor is the MS-ring, which is composed entirely of repeats of the FliF subunit. This MS-ring is cri
Externí odkaz:
https://doaj.org/article/fbff2c4cfa3f490d92bd8c36009427d3
Autor:
Anna Mistarz, Matthew Graczyk, Marta Winkler, Prashant K. Singh, Eduardo Cortes, Anthony Miliotto, Song Liu, Mark Long, Li Yan, Aimee Stablewski, Kieran O’Loughlin, Hans Minderman, Kunle Odunsi, Hanna Rokita, A.J. Robert McGray, Emese Zsiros, Danuta Kozbor
Publikováno v:
Molecular Therapy: Oncolytics, Vol 23, Iss , Pp 38-50 (2021)
We have demonstrated that oncolytic vaccinia virus synergizes with doxorubicin (DOX) in inducing immunogenic cell death in platinum-resistant ovarian cancer cells and increases survival in syngeneic and xenograft tumor models. However, the mechanisms
Externí odkaz:
https://doaj.org/article/9ac365f46fa94257acf87de89c821ff0
Autor:
Sean H. Colligan, Andrea M. Amitrano, Robert A. Zollo, Jennifer Peresie, Elliot D. Kramer, Brian Morreale, Joseph Barbi, Prashant K. Singh, Han Yu, Jianmin Wang, Mateusz Opyrchal, David B. Sykes, Michael J. Nemeth, Scott I. Abrams
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 23 (2022)
While immune checkpoint inhibitors (ICIs) have transformed the therapeutic landscape in oncology, they are effective in select subsets of patients. Efficacy may be limited by tumor-driven immune suppression, of which 1 key mechanism is the developmen
Externí odkaz:
https://doaj.org/article/0a0122b323af493baa53eae9ada9561e
Autor:
Pei-Fen Kuan, Xiaohua Yang, Xu Ren, Chang Che, Monika Waszczuk, Roman Kotov, Sean Clouston, Prashant K. Singh, Sean T. Glenn, Eduardo Cortes Gomez, Jianmin Wang, Evelyn Bromet, Benjamin J. Luft
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Gene expression has provided promising insights into the pathophysiology of post-traumatic stress disorder (PTSD); however, specific regulatory transcriptomic mechanisms remain unknown. The present study addressed this limitation by performi
Externí odkaz:
https://doaj.org/article/af1faf7971174a87a2b57a250711aea3
Publikováno v:
Epigenetics & Chromatin, Vol 14, Iss 1, Pp 1-13 (2021)
Abstract Background ΔNp63 is a master transcriptional regulator playing critical roles in epidermal development and other cellular processes. Recent studies suggest that ΔNp63 functions as a pioneer factor that can target its binding sites within i
Externí odkaz:
https://doaj.org/article/a15d84081f2c437eb5a4e796b77f65ed