Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Prashant B. Nigade"'
Autor:
Mahip K. Verma, Charudatt Samant, Ramesh Kale, Sukanya Patra, Nilesh Mahajan, Milind K. Gholve, Ajitkumar Marisetti, Brahmam Sunkara, Aditya Naik, Manisha Shingare, Madhusudhan Reddy, Anand M. Bokare, Atul Akarte, Sarita Koul, Prashant B. Nigade, Vinod B. Patil, Dipak Modi, Prajakta Ahirrao, Shashikant Pawar, Sandip Kuldharan, Lal Dinchhana, Maneesh Mehta, Jayasagar Gundu, Nirmal Jana, Prashant Vidhate, Sachin Jaysing Mahangare, Manojkumar R. Shukla, Rajan N. Goel, Mandar Bhonde, Rajender Kumar Kamboj, Venkata P. Palle
Publikováno v:
Biochemical and Biophysical Research Communications. 637:267-275
Phosphoinositide 3-kinase (PI3K) pathway mediates key signaling events downstream to B-cell receptor (BCR) for survival of mature B-cells, and overexpression or overactivation of PI3Kδ is crucial for B-cell malignancies such as diffuse large B-cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4587d39fd2411d176cb38bbd74a04cae
https://doi.org/10.1016/j.bbrc.2022.11.038
https://doi.org/10.1016/j.bbrc.2022.11.038
Autor:
Shashikant Pawar, Vinod Patil, Rajender Kumar Kamboj, Milind Sindkhedkar, Trupti Bhankhede, Venkata P. Palle, Jaysagar Gundu, Spinvin Venugopal, Dhananjay Bakhle, Praveenkumar Anidil Kizhakinagath, Kumar Naik, Sanjay Bokan, Zubair Shaikh, Sagar Budhe, Vikas Shinde, Dipak Modi, M. K. Singh, Maneesh Mehta, Kamlesh J Padiya, Gururaj Vishwase, Akshaya Wagh, Rajesh Gupta, Sharad Sharma, Hemant Kumar, Sandip Kuldharan, Sadanand Mallurwar, Neelima Sinha, Gokul Deshmukh, Kaustubh Tamane, Himani Pareek, Rajesh Yeshodharan, Prashant B. Nigade, Milind Gholve, Kumar V S Nemmani, Santosh Jachak, Dilip Pandey, Nidhi Sharma, Vijay Karche, Lakshmi Narasimham, Nageswara Rao Irlapatti, Jagadeesh Daler, Rajesh Shankar, Nilesh Raghunath Khedkar, Mandar Bhonde, Vijay Kanoje, Prabakaran Kamalakannan, Chirag Shah, Shaji K George, Sachin Ingawale, Prajakta Ahirrao, Disha Dadke, Harshal Narendra Nemade, Anil Kalia, Amit Patil, Samiron Phukan, Swaroop Kumar
Publikováno v:
Journal of Medicinal Chemistry. 64:17004-17030
The role of calcium release-activated calcium (CRAC) channels is well characterized and is of particular importance in T-cell function. CRAC channels are involved in the pathogenesis of several autoimmune diseases, making it an attractive therapeutic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc2c7afc213cb2f010008814556ab51c
https://doi.org/10.1021/acs.jmedchem.1c01403
https://doi.org/10.1021/acs.jmedchem.1c01403
Autor:
Anand Tarage, Gopal Gole, Mandar Bhonde, Madhusudhan Reddy, Sharad Sharma, Harish Volam, Sudeep Sabde, Sanjeev Anant Kulkarni, Sadanand Mallurwar, Brahmam Sunkara, Ramesh Dattatraya Phadtare, Manoj Dandekar, Hemant Goyal, Samiron Phukan, Gayathri Sadasivam, Rupesh Kanhere, Maneesh Mehta, Nirmal Jana, Murthy Cheemala, Prashant Vidhate, Lal Dinchhana, Prashant B. Nigade, Bernstein Peter Robert, Prajakta Ahirrao, Rajan Goel, Aditya Naik, Vipul Pachpute, Sukanya Patra, Rajender Kumar Kamboj, Nilesh Mahajan, Kaustubh Tamane, Sneha Trivedi, M. K. Singh, Ajit Kumar Marisetti, Shankar Bhagwat, Mahip Verma, Atul Akarte, Dipak Lagad, Charudatt Samant, Venkata P. Palle, Vinod Patil, Anand Bokare, Dipak Modi, Chaitanya A. Kulkarni, Lakshmi Narasimham, Neetinkumar Reddy, Majid Bashir Sayyed, Sarita Koul, Shukla Manojkumar Ramprasad, Milind Gholve, Swati Tota, Vinod D. Chaudhari, Jayasagar Gundu, Manisha Shingare, Sachin J Mahangare, Shashikant Pawar
Publikováno v:
Journal of Medicinal Chemistry. 63:14700-14723
PI3Kδ inhibitors have been approved for B-cell malignancies like CLL, small lymphocytic lymphoma, and so forth. However, currently available PI3Kδ inhibitors are nonoptimal, showing weakness against at least one of the several important properties:
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4614f9af4bf378b9f2f87f030837f97
https://doi.org/10.1021/acs.jmedchem.0c01264
https://doi.org/10.1021/acs.jmedchem.0c01264
Autor:
Shreyas Deshpande, Rashmi Talwar, Ganesh Navinchandra Gote, Jayasagar Gundu, Rupali Vyawahare, Shashikant Pawar, Akshaya Wagh, Talha Khan, Anil Kalia, Venkata P. Palle, Usha Dhayagude, M. K. Singh, Pradeep Patil, Ganesh Chaure, Praveen Kumar Gupta, Amit Das, Vijay Kanoje, Sharad Sharma, Vidya Ramdas, Vinod Patil, Rajesh Yeshodharan, Prashant B. Nigade, Dipak Modi, Dnyaneshwar Warude, Dilip Pandey, Jagadeesh Daler, Mahammad Azhar, Arun Nayak, Sneha Joshi, Sudipto Das, Rajender Kumar Kamboj, Javed S Shaikh, Maneesh Mehta, Deepak Sahebrao Walke, Rajesh V. Gupta, Himani Pareek, Kumar V S Nemmani, Parag Joshi, Mahip Verma, Vinod Mali, Laxmikant Datrange, Santosh Parkale, Rajesh Loriya, Vaibhav Kalhapure, Geetika Sharma, Ravindra R. Pal, Sagar Budhe, Gautam Agarwal, Sachin Suravase, Sagar Darekar, Mark G. Bock, Advait Arun Joshi, Moloy Banerjee, Smita Bhoskar, Amitesh Kishore, Dhananjay Bakhle
Publikováno v:
Journal of Medicinal Chemistry. 63:6107-6133
Voltage-gated sodium channel NaV1.7 is a genetically validated target for pain. Identification of NaV1.7 inhibitors with all of the desired properties to develop as an oral therapeutic for pain has been a major challenge. Herein, we report systematic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::086c900f1a53e7be6872ad0b9e12f6e4
https://doi.org/10.1021/acs.jmedchem.0c00361
https://doi.org/10.1021/acs.jmedchem.0c00361
Autor:
Sagar J. Desai, Sameer S. Walunj, Anand M. Bokare, Sharad Sharma, Dhananjay Bakhle, Sachchidanand Sachchidanand, Mahip K. Verma, Rajesh Gupta, Vijaya Mahimane, Jayasagar Gundu, Baban Rupaji Thube, Prashant B. Nigade, Firoj Aftab Raje, Chirag Shah, Sanjay Pralhad Kurhade, M. K. Singh, Lairikyengbam Bikramjit Singh, Girish Dhanraj Hatnapure, Shridhar Keshav Adurkar, Rajender Kumar Kamboj, Vinod Patil, Neelima Sinha, Ajay Ramchandra Tilekar, Sudhakar Maruti Balgude, Sarita Koul, Manavi Chatterjee, Anil Kashiram Hajare, Ruchi Dixit, Yogesh Bhosale, Ganesh Rajaram Jadhav, Manoj P. Dandekar, Navnath Popat Karche, Dnyaneshwar Changdeo Bhanage, Ashish P. Bharne, Rajan Goel, Javed S Shaikh, Gourhari Jana, Dipak Modi, Maneesh Mehta, Venkata P. Palle
Publikováno v:
Journal of Medicinal Chemistry. 63:944-960
The discovery of a series of thiophenephenylsulfonamides as positive allosteric modulators (PAM) of α7 nicotinic acetylcholine receptor (α7 nAChR) is described. Optimization of this series led to identification of compound 28, a novel PAM of α7 ni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a58527c53cdd9032bedaf222277ce22
https://doi.org/10.1021/acs.jmedchem.9b01569
https://doi.org/10.1021/acs.jmedchem.9b01569
Autor:
Pratima Srivastava, Arnab Goswami, Amruta Dash, Deepak Sahebrao Walke, Gautam Agarwal, Dipak Modi, Moloy Banerjee, Rajender Kumar Kamboj, Rashmi Talwar, Hemant Kumar, Falguni Modi, Advait Arun Joshi, Aruna Sivaram, Venkata P. Palle, Vinod Patil, Lakshmi Narasimham, Vidya Ramdas, Ganesh Navinchandra Gote, Sharad Sharma, M. K. Singh, Sadanand Mallurwar, Prashant B. Nigade, Sandip Kuldharan, Prashant Borhade, Rajesh Loriya, Maneesh Mehta, Jayasagar Gundu, Apparao Bommakanti, Usha Dhayagude, Amit Kumar Das
Publikováno v:
Journal of Medicinal Chemistry. 62:10563-10582
The identification of a novel class of potent pan-genotypic NS5A inhibitors with good pharmacokinetic profile suitable for potential use in treating HCV infections is disclosed here. The present series of compounds are with less complex tricyclic cen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df0347f54ddf821889bfcaf5e07c536e
https://doi.org/10.1021/acs.jmedchem.9b01562
https://doi.org/10.1021/acs.jmedchem.9b01562
Autor:
Anand M. Bokare, Venkata P. Palle, Maneesh Mehta, Sameer S. Walunj, Sarita Koul, Mahip K. Verma, Dipak Modi, Navnath Popat Karche, Rajan Goel, Vinod Patil, Nilendra Singh, Santoshkumar Tota, Neelima Sinha, Jayasagar Gundu, Sagar Desai, Prashant B. Nigade, Rajender Kumar Kamboj, Manoj P. Dandekar
Publikováno v:
European journal of pharmacology. 891
α7 nicotinic acetylcholine receptor (α7 nAChR) is an extensively validated target for several neurological and psychiatric conditions namely, dementia and schizophrenia, owing to its vital roles in cognition and sensorimotor gating. Positive allost
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50dee4d769e8c9421b7d3480a20167f2
https://pubmed.ncbi.nlm.nih.gov/33127363
https://pubmed.ncbi.nlm.nih.gov/33127363
Autor:
Vidya, Ramdas, Rashmi, Talwar, Vijay, Kanoje, Rajesh M, Loriya, Moloy, Banerjee, Pradeep, Patil, Advait Arun, Joshi, Laxmikant, Datrange, Amit Kumar, Das, Deepak Sahebrao, Walke, Vaibhav, Kalhapure, Talha, Khan, Ganesh, Gote, Usha, Dhayagude, Shreyas, Deshpande, Javed, Shaikh, Ganesh, Chaure, Ravindra R, Pal, Santosh, Parkale, Sachin, Suravase, Smita, Bhoskar, Rajesh V, Gupta, Anil, Kalia, Rajesh, Yeshodharan, Mahammad, Azhar, Jagadeesh, Daler, Vinod, Mali, Geetika, Sharma, Amitesh, Kishore, Rupali, Vyawahare, Gautam, Agarwal, Himani, Pareek, Sagar, Budhe, Arun, Nayak, Dnyaneshwar, Warude, Praveen Kumar, Gupta, Parag, Joshi, Sneha, Joshi, Sagar, Darekar, Dilip, Pandey, Akshaya, Wagh, Prashant B, Nigade, Maneesh, Mehta, Vinod, Patil, Dipak, Modi, Shashikant, Pawar, Mahip, Verma, Minakshi, Singh, Sudipto, Das, Jayasagar, Gundu, Kumar, Nemmani, Mark G, Bock, Sharad, Sharma, Dhananjay, Bakhle, Rajender Kumar, Kamboj, Venkata P, Palle
Publikováno v:
Journal of medicinal chemistry. 63(11)
Voltage-gated sodium channel Na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c52c66d3e92a25570d2232b2452b0ca7
https://pubmed.ncbi.nlm.nih.gov/32368909
https://pubmed.ncbi.nlm.nih.gov/32368909
Publikováno v:
European Journal of Drug Metabolism and Pharmacokinetics. 42:835-847
Majority of reported studies so far developed correlation regression equations using the rat muscle-to-plasma drug concentration ratio (Kp-muscle) to predict tissue-to-plasma drug concentration ratios (Kp-tissues). Use of regression equations derived
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1719a72ccf3e94398e3f2e2d40a1e22b
https://doi.org/10.1007/s13318-017-0402-5
https://doi.org/10.1007/s13318-017-0402-5
Autor:
Albi Francis, Javed S. Shaikh, Tariq Bhat, Sanjay P. Kurhade, Nivrutti Kamble, Harish Volam, Sadanand Mallurwar, Pushpak Bora, Prashant B. Nigade, Mandar Bhonde, Hemant Goyal, Gagan Kukreja, Nishant R. Gupta, Nageswara Rao Irlapati, Prajakta Ahirrao, Bernstein Peter Robert, Rajesh B. Shankar, Kumar Ram Naik, Sneha Naidu, Gopal Gole, Yogesh Pawar, Apparao Bommakanti, Vinod Patil, Rajendra G. Powar, V.R. Praveen Kumar, Rakesh Kumar, Prabhakaran Kamalakannan, Anil K. Hajare, Neelima Sinha, Rajender Kumar Kamboj, Jayasagar Gundu, Sharad Sharma, Nilesh Khedkar, Arun R. Jagdale, Navnath P. Karche, Venkata P. Palle, Dipak Modi, Saif Wahid, Vamsi Pagdala, Kochumalayil Shaji George, Ganesh R. Jadhav, Gourhari Jana, Rohan Limaye, Baban Thube, Lakshmi Narasimham, Harshal Khanwalkar, Shashikant Pawar, Kumar V.S. Nemmani, Rajesh Gupta, Minakshi Singh, Ramesh Kale, Ajay R. Tilekar, Samiron Phukan, Dhananjay Bakhle, Pradipta Kumar
Publikováno v:
Bioorganic & Medicinal Chemistry. 28:115819
The exploitation of GLU988 and LYS903 residues in PARP1 as targets to design isoquinolinone (I & II) and naphthyridinone (III) analogues is described. Compounds of structure I have good biochemical and cellular potency but suffered from inferior PK.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae439561d9cd7678612504a2221cbc22
https://doi.org/10.1016/j.bmc.2020.115819
https://doi.org/10.1016/j.bmc.2020.115819