Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Prasanthi Govindraj"'
Publikováno v:
Biochemical Journal. 361:231-241
Point mutations in the human fibroblast growth factor (FGF) receptor 3 gene (Fgfr3) produce a constitutively active receptor, which disrupts chondrocyte differentiation in the growth plate and results in skeletal dysplasias with severe shortening of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc4f6b4ac3e051976466990d5eca358e
https://doi.org/10.1042/bj3610231
https://doi.org/10.1042/bj3610231
Autor:
Neil S. Silverman, Yoshihiko Yamada, William R. Wilcox, John R. Hassell, Prasanthi Govindraj, Eri Arikawa-Hirasawa, Alexander H. Le
Publikováno v:
Nature Genetics. 27:431-434
Perlecan is a large heparan sulfate (HS) proteoglycan present in all basement membranes and in some other tissues such as cartilage1,2, and is implicated in cell growth and differentiation3,4,5. Mice lacking the perlecan gene6,7 (Hspg2) have a severe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b964029e1a1cea4b2316d8e28b795d3e
https://doi.org/10.1038/86941
https://doi.org/10.1038/86941
Publikováno v:
Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 24(6)
Perlecan is a heparan sulfate proteoglycan present in the growth plate and essential for endochondral ossification. We evaluated the synthesis and structure of perlecan in the different zones of the growth plate. The growth plates from fetal bovine r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5449c47a8526dddaa1c1d0bcc4a9e89
https://pubmed.ncbi.nlm.nih.gov/16705694
https://pubmed.ncbi.nlm.nih.gov/16705694
Publikováno v:
Matrix biology : journal of the International Society for Matrix Biology. 25(4)
FGF-2 is a regulator of chondrocyte proliferation in the developing growth plate and has been shown to bind to perlecan, a heparan sulfate proteoglycan. We evaluated the effect of perlecan isolated from the growth plate on the binding of FGF-2 to its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1e56b8f92346f0bf353e178c8988e6f
https://pubmed.ncbi.nlm.nih.gov/16481152
https://pubmed.ncbi.nlm.nih.gov/16481152
Autor:
Leigh A. West, Prasanthi Govindraj, John R. Hassell, Peter J. Neame, Thomas J. Koob, Kurt Doege
Publikováno v:
The Journal of biological chemistry. 277(22)
Heparan sulfate proteoglycans are thought to mediate the action of growth factors. The heparan sulfate-containing proteoglycans in extracts of the bovine fetal rib growth plate were detected using the monoclonal antibody 3G10, which recognizes a neoe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcc8c66fe04f0e9c1e73efd118f115f7
https://pubmed.ncbi.nlm.nih.gov/11909863
https://pubmed.ncbi.nlm.nih.gov/11909863
Publikováno v:
Matrix biology : journal of the International Society for Matrix Biology. 19(6)
Pleiotrophin and chondromodulin-I are low molecular weight proteins that are abundant (20 μg/g tissue) in fetal cartilage and difficult to detect in adult cartilage. We characterized their gene and protein expression patterns to gain a better unders
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::164e6ecf4254fb621c36621e400b3121
https://pubmed.ncbi.nlm.nih.gov/11068206
https://pubmed.ncbi.nlm.nih.gov/11068206
Autor:
John R. Hassell, Rachel A. Oldershaw, J.T. Hecht, Z.M. Scholefield, Graham Rushton, Leigh A. West, Timothy E. Hardingham, John T. Gallagher, Catherine L.R. Merry, Prasanthi Govindraj
Publikováno v:
International Journal of Experimental Pathology. 85:A73-A74
Introduction Heparin sulfate (HS) has long been implicated in the bone deformity hereditary multiple exostoses (HME), and it is now clear that HME is associated with mutations in the HS biosynthetic genes EXT1 and EXT2. Interestingly, HME is also ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f680de1167480a9d41a963c74a9de017
https://doi.org/10.1111/j.0959-9673.2004.390an.x
https://doi.org/10.1111/j.0959-9673.2004.390an.x
Autor:
John R. Hassell, Leigh A. West, Prasanthi Govindraj, David M. Qrnitz, Simone M. Smith, Xiuqin Zhang
Publikováno v:
Matrix Biology. 26:583
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::151b59a1e54d08f5d5154d6275a26dd6
https://doi.org/10.1016/j.matbio.2007.05.007
https://doi.org/10.1016/j.matbio.2007.05.007
Autor:
Eri Arikawa-Hirasawa, Prasanthi Govindraj, Marinos C. Dalakas, Yoshihiko Yamada, Ikuya Nonaka, Jürgen Spranger, Nicola C. Ho, Joseph M. Devaney, John R. Hassell, Susan T. Iannaccone, Clair A. Francomano, Ichizo Nishino, Roger E. Stevenson, Alexander H. Le
Publikováno v:
The American Journal of Human Genetics. (5):1368-1375
Perlecan, a large heparan sulfate proteoglycan, is a component of the basement membrane and other extracellular matrices and has been implicated in multiple biological functions. Mutations in the perlecan gene (HSPG2) cause two classes of skeletal di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::979bd77a11a3b80627a15dfd25334af9