Výsledky vyhledávání - "Prasanth Saraswati A"

Anti-fibrillization effects of sulfonamide derivatives on

Autor: Jessica S, Fortin, Kazuma, Shimanaka, A Prasanth, Saraswati, Mengyu, Liu, Kuang-Wei, Wang, Hsiao-Tien, Hagar, Soham, Maity, Susantha K, Ganegamage, Edmund, Ellsworth, Scott E, Counts, Babak, Borhan, Ulf, Dettmer, Min-Hao, Kuo

Publikováno v: J Mol Struct

In contrast to Aβ plaques, the spatiotemporal distribution of neurofibrillary tangles of hyperphosphorylated tau (p-tau) predicts cognitive impairment in Alzheimer’s disease (AD), underscoring the key pathological role of p-tau and the utmost need

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e9966e569ae4658f6a4cb9e72fec1491
https://pubmed.ncbi.nlm.nih.gov/36310922

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Design and Synthesis of Oligopeptidic Parvulin Inhibitors

Autor: Nicola Relitti, A. Prasanth Saraswati, Gabriele Carullo, Alessandro Papa, Alessandra Monti, Rosaria Benedetti, Eugenia Passaro, Simone Brogi, Vincenzo Calderone, Stefania Butini, Sandra Gemma, Lucia Altucci, Giuseppe Campiani, Nunzianna Doti

Pin1 catalyzes the cis-trans isomerization of pThr-Pro or pSer-Pro amide bonds of various proteins involved in several physio/pathological processes. In this framework, recent research activity is directed toward the identification of new selective P

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb06426a1ac1036f7dd8985e1f452a1e
http://hdl.handle.net/11568/1142788

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(+)-(R)- and (-)-(S)-Perhexiline maleate: Enantioselective synthesis and functional studies on Schistosoma mansoni larval and adult stages

Autor: Orazio Taglialatela-Scafati, A Prasanth Saraswati, Fulvio Saccoccia, Giovina Ruberti, Carmina Sirignano, Giuseppe Campiani, Alessandra Guidi, Roberto Gimmelli, Nicola Relitti, Sandra Gemma

Publikováno v: Bioorganic chemistry
(2020). doi:10.1016/j.bioorg.2020.104067
info:cnr-pdr/source/autori:Alessandra Guidi 1, A Prasanth Saraswati 2, Nicola Relitti 2, Roberto Gimmelli 1, Fulvio Saccoccia 1, Carmina Sirignano 3, Orazio Taglialatela-Scafati 3, Giuseppe Campiani 4, Giovina Ruberti 5, Sandra Gemma/titolo:(+)-(R)-and (-)-(S)-Perhexiline maleate: Enantioselective synthesis and functional studies on Schistosoma mansoni larval and adult stages/doi:10.1016%2Fj.bioorg.2020.104067/rivista:Bioorganic chemistry (Print)/anno:2020/pagina_da:/pagina_a:/intervallo_pagine:/volume

Schistosomiasis is a neglected tropical disease mainly affecting the poorest tropical and subtropical areas of the world with the impressive number of roughly 200 million infections per year. Schistosomes are blood trematode flukes of the genus Schis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a24a66ac8c2f6dd7457d6ff69a1a3d00
https://pubmed.ncbi.nlm.nih.gov/32663671

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Spiroindoline-Capped Selective HDAC6 Inhibitors: Design, Synthesis, Structural Analysis, and Biological Evaluation

Publikováno v: Saraswati, A P, Relitti, N, Brindisi, M, Osko, J D, Chemi, G, Federico, S, Grillo, A, Brogi, S, McCabe, N H, Turkington, R C, Ibrahim, O, O'Sullivan, J, Lamponi, S, Ghanim, M, Kelly, V P, Zisterer, D, Amet, R, Hannon Barroeta, P, Vanni, F, Ulivieri, C, Herp, D, Sarno, F, Di Costanzo, A, Saccoccia, F, Ruberti, G, Jung, M, Altucci, L, Gemma, S, Butini, S, Christianson, D W & Campiani, G 2020, ' Spiroindoline-Capped Selective HDAC6 Inhibitors: Design, Synthesis, Structural Analysis, and Biological Evaluation ', ACS MEDICINAL CHEMISTRY LETTERS, vol. 11, no. 11, pp. 2268-2276 . https://doi.org/10.1021/acsmedchemlett.0c00395
ACS Med Chem Lett
ACS medicinal chemistry letters (2020). doi:10.1021/acsmedchemlett.0c00395
info:cnr-pdr/source/autori:A Prasanth Saraswati 1, Nicola Relitti 1, Margherita Brindisi 1, Jeremy D Osko 2, Giulia Chemi 1, Stefano Federico 1, Alessandro Grillo 1, Simone Brogi 3, Niamh H McCabe 4, Richard C Turkington 4, Ola Ibrahim 5, Jeffrey O'Sullivan 5, Stefania Lamponi 1, Magda Ghanim 6, Vincent P Kelly 6, Daniela Zisterer 6, Rebecca Amet 6, Patricia Hannon Barroeta 6, Francesca Vanni 7, Cristina Ulivieri 7, Daniel Herp 8, Federica Sarno 9, Antonella Di Costanzo 9, Fulvio Saccoccia 10, Giovina Ruberti 10, Manfred Jung 8, Lucia Altucci 9, Sandra Gemma 1, Stefania Butini 1, David W Christianson 2, Giuseppe Campiani/titolo:Spiroindoline-Capped Selective HDAC6 Inhibitors: Design, Synthesis, Structural Analysis, and Biological Evaluation/doi:10.1021%2Facsmedchemlett.0c00395/rivista:ACS medicinal chemistry letters/anno:2020/pagina_da:/pagina_a:/intervallo_pagine:/volume
ACS Medicinal Chemistry Letters

[Image: see text] Histone deacetylase inhibitors (HDACi) have emerged as promising therapeutics for the treatment of neurodegeneration, cancer, and rare disorders. Herein, we report the development of a series of spiroindoline-based HDAC6 isoform-sel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bdda0b9bb58feac3ff72ae889a7ab41
https://pure.qub.ac.uk/en/publications/spiroindolinecapped-selective-hdac6-inhibitors-design-synthesis-structural-analysis-and-biological-evaluation(5bed77f3-2eb8-4bef-8802-360242d740c1).html

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Old but Gold: Tracking the New Guise of Histone Deacetylase 6 (HDAC6) Enzyme as a Biomarker and Therapeutic Target in Rare Diseases

Autor: Stefania Butini, Giuseppe Campiani, Simone Brogi, Margherita Brindisi, Sandra Gemma, A Prasanth Saraswati

Epigenetic regulation orchestrates many cellular processes and greatly influences key disease mechanisms. Histone deacetylase (HDAC) enzymes play a crucial role either as biomarkers or therapeutic targets owing to their involvement in specific pathop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7d08a23b8b9aa3de15637803a4d03f4
http://hdl.handle.net/11588/768203

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Development of New Drugs for the Treatment of Oral Cancers

Autor: AKELLA, PRASANTH SARASWATI

Le terapie epigenetiche rappresentano una delle aree pi� promettenti e innovative della scienza moderna. In particolare, l'uso di inibitori delgli enzimi della famiglia histone deacetylases (HDAC) 'HDAC ha acquisito un notevole interesse come strum

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23f943407f85a468cb8f60bc88f8f971
http://hdl.handle.net/11365/1110949

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Raising the bar in anticancer therapy: recent advances in, and perspectives on, telomerase inhibitors

Autor: Daniela M. Zisterer, Nicola Relitti, Giuseppe Campiani, Margherita Brindisi, Sandra Gemma, Stefania Butini, A Prasanth Saraswati

Publikováno v: Drug Discovery Today

Telomerase is a ribonucleic reverse transcriptase enzyme that uses an integral RNA component as a template to add tandem telomeric DNA repeats, TTAGGG, at the 3' end of the chromosomes. 85-90% of human tumors and their derived cell lines predominantl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b9c6b899d356b19b3741b0a91c58acd
http://hdl.handle.net/11588/760586

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