Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Prasanth R. Nyalapatla"'
Autor:
Mariarosaria De Rosa, Ryan P. Barnes, Prasanth R. Nyalapatla, Peter Wipf, Patricia L. Opresko
SUMMARYTelomeres are prone to formation of the common oxidative lesion 8-oxoguanine (8oxoG), and the acute production of 8oxoG damage at telomeres is sufficient to drive rapid cellular senescence. OGG1 and MUTYH glycosylases initiate base excision re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f74121c7e50b3237e0ae621c1664890
https://doi.org/10.1101/2023.04.10.536247
https://doi.org/10.1101/2023.04.10.536247
Autor:
Arshad J. Ansari, Sahil Arora, Hariprasad Aruri, Yogita Bansal, Gulshan Bansal, Joydeep Chatterjee, K.M. Divita, Navnath S. Gavande, Gaurav Joshi, Madhurendra K. Katiyar, Manpreet Kaur, Navneet Kaur, Jeremy M. Kelm, Gopal L. Khatik, Manvendra Kumar, Rakesh Kumar, Raj Kumar, Pradeep Kumar, Pritam Maity, Prasanth R. Nyalapatla, Dimpy Rani, Pankaj Kumar Singh, Aprajita Srivastava, Shikha Thakur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a29e97e66f40bb2d247faba852a70e94
https://doi.org/10.1016/b978-0-443-18616-5.01002-4
https://doi.org/10.1016/b978-0-443-18616-5.01002-4
Autor:
Manabu Aoki, Hironori Hayashi, Kalapala Venkateswara Rao, Debananda Das, Nobuyo Higashi-Kuwata, Haydar Bulut, Hiromi Aoki-Ogata, Yuki Takamatsu, Ravikiran S Yedidi, David A Davis, Shin-ichiro Hattori, Noriko Nishida, Kazuya Hasegawa, Nobutoki Takamune, Prasanth R Nyalapatla, Heather L Osswald, Hirofumi Jono, Hideyuki Saito, Robert Yarchoan, Shogo Misumi, Arun K Ghosh, Hiroaki Mitsuya
Publikováno v:
eLife, Vol 6 (2017)
Antiretroviral therapy for HIV-1 infection/AIDS has significantly extended the life expectancy of HIV-1-infected individuals and reduced HIV-1 transmission at very high rates. However, certain individuals who initially achieve viral suppression to un
Externí odkaz:
https://doaj.org/article/cad83cc5723344c2b39ea3ee8fd9acc9
Autor:
Kanury V. S. Rao, Prasanth R. Nyalapatla, Hiroaki Mitsuya, Hironori Hayashi, Arun K. Ghosh, Debananda Das, Hiromi Aoki-Ogata, David A. Davis, Shin-ichiro Hattori, Haydar Bulut, Manabu Aoki
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports
Scientific Reports
HIV-1 protease inhibitors (PIs), such as darunavir (DRV), are the key component of antiretroviral therapy. However, HIV-1 often acquires resistance to PIs. Here, seven novel PIs were synthesized, by introducing single atom changes such as an exchange
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f538916898916206ff82e08ff58f97a9
https://doi.org/10.1038/s41598-020-65993-z
https://doi.org/10.1038/s41598-020-65993-z
Autor:
Mary J. Wirth, Chittaranjan Das, Jiaqi Fu, Kedar Puvar, Yiyang Zhou, Aya M. Saleh, Yitzhak Tor, Alexander R. Rovira, Ryan Curtis, Prasanth R. Nyalapatla, Arun K. Ghosh, Tamara L. Kinzer-Ursem, Jean Chmielewski, Zhao-Qing Luo
Publikováno v:
Biochemistry, vol 59, iss 13
Biochemistry
Biochemistry
In a radical departure from the classical E1–E2–E3 three-enzyme mediated ubiquitination of eukaryotes, the recently described bacterial enzymes of the SidE family of Legionella pneumophila effectors utilize NAD(+) to ligate ubiquitin onto target
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76a30c2628d96201d7d6d6971a4d0e1b
https://escholarship.org/uc/item/0302p919
https://escholarship.org/uc/item/0302p919
Publikováno v:
Synlett. 30:471-476
A four-step synthesis of the FDA-approved anticancer agent gefitinib was developed starting from 2,4-dichloro-6,7-dimethoxyquinazoline. Reaction temperatures were highly practical (0–55 °C), and chromatographic purifications were avoided. The ioni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::211f70a4fe1e8025bc3ac333fed62b3f
https://doi.org/10.1055/s-0037-1610375
https://doi.org/10.1055/s-0037-1610375
Autor:
Satish Kovela, Heather L. Osswald, Manabu Aoki, Arun K. Ghosh, Masayuki Amano, Kanury V. S. Rao, Johnson Agniswamy, Yuan-Fang Wang, Irene T. Weber, Hiroaki Mitsuya, Prasanth R. Nyalapatla, Margherita Brindisi
Publikováno v:
Journal of Medicinal Chemistry. 61:4561-4577
The design, synthesis, and biological evaluation of a new class of HIV-1 protease inhibitors containing stereochemically defined fused tricyclic polyethers as the P2 ligands and a variety of sulfonamide derivatives as the P2′ ligands, are described
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca06c578663722668527273bbfc1ad4e
https://doi.org/10.1021/acs.jmedchem.8b00298
https://doi.org/10.1021/acs.jmedchem.8b00298
Autor:
Prasanth R. Nyalapatla, Arun K. Ghosh
Publikováno v:
Tetrahedron. 73:1820-1830
The total syntheses of (−)-amphirionin-4 and (+)-amphirionin-4 have been achieved in a convergent and enantioselective manner. The tetrahydrofuranol cores of amphirionin-4 were constructed in optically active form by enzymatic resolution of racemic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91a74e75cf93e8e1182b6951ce6e4e37
https://doi.org/10.1016/j.tet.2017.02.031
https://doi.org/10.1016/j.tet.2017.02.031
Publikováno v:
ChiralityREFERENCES. 31(12)
Three cis-selective Co(II)-salen complexes have been developed for the asymmetric cyclopropanation of para-fluorinated styrenes with ethyl diazoacetate. Increasing the steric reach of the C2 -symmetric ligand side chains improved the enantiomeric rat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd57e99c8aca1eee1d99c903c42ee261
https://pubmed.ncbi.nlm.nih.gov/31680333
https://pubmed.ncbi.nlm.nih.gov/31680333