Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Prasannavenkatesh Durai"'
Publikováno v:
Journal of Cheminformatics, Vol 15, Iss 1, Pp 1-14 (2023)
Abstract Machine learning-based chemical screening has made substantial progress in recent years. However, these predictions often have low accuracy and high uncertainty when identifying new active chemical scaffolds. Hence, a high proportion of retr
Externí odkaz:
https://doaj.org/article/3c69f1e661164f28a6ca10ed64913fa8
Publikováno v:
BMC Bioinformatics, Vol 21, Iss 1, Pp 1-18 (2020)
Abstract Background Despite continued efforts using chemical similarity methods in virtual screening, currently developed approaches suffer from time-consuming multistep procedures and low success rates. We recently developed a machine learning-based
Externí odkaz:
https://doaj.org/article/2e97ecafbb3548049af153419672647b
Autor:
Eun-Ji Park, Keunwan Park, Prasannavenkatesh Durai, Ki-Young Kim, So-Young Park, Jaeyoung Kwon, Hee Ju Lee, Cheol-Ho Pan, Kwang-Hyeon Liu
Publikováno v:
Pharmaceutics, Vol 14, Iss 12, p 2683 (2022)
Obtusifolin, a major anthraquinone component present in the seeds of Cassia tora, exhibits several biological activities, including the amelioration of memory impairment, prevention of breast cancer metastasis, and reduction of cartilage damage in os
Externí odkaz:
https://doaj.org/article/c9efa77fed804dada867533efad3b03e
Autor:
Jaeyoung Kwon, Kyerim Lee, Hoseong Hwang, Seong-Hwan Kim, Se Eun Park, Prasannavenkatesh Durai, Keunwan Park, Hyung-Seop Kim, Dae Sik Jang, Jae Sue Choi, Hak Cheol Kwon
Publikováno v:
Plants, Vol 11, Iss 15, p 1998 (2022)
Algae are unique natural products that can produce various types of biologically active compounds. The 70% ethanol extract of brown algae Sargassum macrocarpum collected from the East Sea of Korea inhibited human monoamine oxidases A and B enzymes (h
Externí odkaz:
https://doaj.org/article/99d871ce0eeb41b8aed897a2493b70f1
Publikováno v:
Biomedicines, Vol 9, Iss 9, p 1250 (2021)
Natural products (NPs) have played a significant role in drug discovery for diverse diseases, and numerous attempts have been made to discover promising NP inhibitors of tumor necrosis factor α (TNF-α), a major therapeutic target in autoimmune dise
Externí odkaz:
https://doaj.org/article/6d92d5c3a0d64d8687436d4089a23afc
Publikováno v:
Molecules, Vol 26, Iss 3, p 566 (2021)
Tyrosinase is an enzyme that plays a crucial role in the melanogenesis of humans and the browning of food products. Thus, tyrosinase inhibitors that are useful to the cosmetic and food industries are required. In this study, we have used evolutionary
Externí odkaz:
https://doaj.org/article/5f303818798845358b92875d966bf527
Autor:
Suresh Panneerselvam, Dhanusha Yesudhas, Prasannavenkatesh Durai, Muhammad Ayaz Anwar, Vijayakumar Gosu, Sangdun Choi
Publikováno v:
Molecules, Vol 20, Iss 8, Pp 14915-14935 (2015)
Cytarabine, daunorubicin, doxorubicin and vincristine are clinically used for combinatorial therapies of cancers in different combinations. However, the knowledge about the interaction of these drugs with the metabolizing enzyme cytochrome P450 is li
Externí odkaz:
https://doaj.org/article/b9e391497a2d4c59aeee0274556ddde7
Publikováno v:
Marine Drugs, Vol 13, Iss 7, Pp 4217-4230 (2015)
Lipopolysaccharide (LPS) is a component of the outer membrane of mainly Gram-negative bacteria and cyanobacteria. The LPS molecules from marine and terrestrial bacteria show structural variations, even among strains within the same species living in
Externí odkaz:
https://doaj.org/article/aaf446572b84420985c663277027ed47
Autor:
Dhanusha Yesudhas, Muhammad Ayaz Anwar, Suresh Panneerselvam, Prasannavenkatesh Durai, Masaud Shah, Sangdun Choi
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0147240 (2016)
The octamer-binding transcription factor 4 (Oct4) and sex-determining region Y (SRY)-box 2 (Sox2) proteins induce various transcriptional regulators to maintain cellular pluripotency. Most Oct4/Sox2 complexes have either 0 base pairs (Oct4/Sox2(0bp))
Externí odkaz:
https://doaj.org/article/fd5e86ac948240eab4ac4bb3182100d8
Autor:
Jieun Kim, Prasannavenkatesh Durai, Dasom Jeon, In Duk Jung, Seung Jun Lee, Yeong-Min Park, Yangmee Kim
Publikováno v:
Nutrients, Vol 10, Iss 7, p 868 (2018)
Toll-like receptor 2 (TLR2) responses are involved in various inflammatory immune disorders. Phloretin is a naturally occurring dietary flavonoid that is abundant in fruit. Here, we investigated whether the anti-inflammatory activity of phloretin is
Externí odkaz:
https://doaj.org/article/3dc939b0e077493f8b0136740e1c074b