Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Prasanna Sivaprakasam"'
Autor:
Richard A. Hartz, Vijay T. Ahuja, Prasanna Sivaprakasam, Hong Xiao, Carol M. Krause, Wendy J. Clarke, Kevin Kish, Hal Lewis, Nicolas Szapiel, Ramu Ravirala, Sayali Mutalik, Deepa Nakmode, Devang Shah, Catherine R. Burton, John E. Macor, Gene M. Dubowchik
Publikováno v:
Journal of Medicinal Chemistry. 66:4231-4252
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c0e6aab6246e0fca5a7a308d8d66217
https://doi.org/10.1021/acs.jmedchem.3c00133
https://doi.org/10.1021/acs.jmedchem.3c00133
Autor:
Richard A. Hartz, Vijay T. Ahuja, Guanglin Luo, Ling Chen, Prasanna Sivaprakasam, Hong Xiao, Carol M. Krause, Wendy J. Clarke, Songmei Xu, John S. Tokarski, Kevin Kish, Hal Lewis, Nicolas Szapiel, Ramu Ravirala, Sayali Mutalik, Deepa Nakmode, Devang Shah, Catherine R. Burton, John E. Macor, Gene M. Dubowchik
Publikováno v:
Journal of Medicinal Chemistry.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::973dc3947e6104a7b54e9172d7ba1d5f
https://doi.org/10.1021/acs.jmedchem.3c00364
https://doi.org/10.1021/acs.jmedchem.3c00364
Autor:
Guanglin Luo, Ling Chen, Swanee Jacutin-Porte, Catherine R. Burton, Hong Xiao, Prasanna Sivaprakasam, Carol M. Krause, Yang Cao, Nengyin Liu, Michelle Nophsker, Kimberly Snow, Wendy J. Clarke, Kevin Kish, Hal Lewis, John E. Macor, Gene M. Dubowchik
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad30add637bc21523a74e6c3a8104703
https://doi.org/10.2139/ssrn.4411756
https://doi.org/10.2139/ssrn.4411756
Autor:
Michael A. Schmidt, Chunshan Xie, Naidu S. Chowdari, Ankita G. Niyogi, David R. Langley, Heng Cheng, Gregory D. Vite, Sivakrishna Guturi, Rajappa Vaidyanathan, Sanjeev Gangwar, Ivar M. McDonald, Kishorekumar Kanagavel, Yichen Tan, Prasanna Sivaprakasam, Souvik Rakshit, Chin Pan, Umamaheswararao Kanusu, Martin D. Eastgate, Madhura Deshpande, Somprabha Sidhar, Bin Zheng, Christiana I. Iwuagwu, Michael R. Luzung, Ganapathy Sarma, Kevin M. Peese, Thirumalai Lakshminarasimhan, Patrick G. Holder, Pina M. Cardarelli, Patricia Cho, Srikanth Kotapati, Chetana Rao
Publikováno v:
ACS Med Chem Lett
[Image: see text] A new series with the tetrahydroisoquinoline-fused benzodiazepine (TBD) ring system combined with the surrogates of (1-methyl-1H-pyrrol-3-yl)benzene (“MPB”) payloads were designed and executed for conjugation with a monoclonal a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ebc8e44bdde09da681c8a7885776a0f
https://doi.org/10.1021/acsmedchemlett.0c00578
https://doi.org/10.1021/acsmedchemlett.0c00578
Autor:
Kyle Parcella, Tao Wang, Kyle Eastman, Zhongxing Zhang, Zhiwei Yin, Manoj Patel, Yong Tu, Barbara Zhizhen Zheng, Michael A. Walker, Mark G. Saulnier, David Frennesson, Michael Bowsher, Eric Gillis, Kevin Peese, Makonen Belema, Christopher Cianci, Ira B. Dicker, Brian McAuliffe, Bo Ding, Paul Falk, Jean Simmermacher, Dawn D. Parker, Prasanna Sivaprakasam, Kevin Kish, Hal Lewis, Umesh Hanumegowda, Susan Jenkins, John F. Kadow, Mark Krystal, Nicholas A. Meanwell, B. Narasimhulu Naidu
Publikováno v:
ACS Med Chem Lett
[Image: see text] Allosteric HIV-1 integrase inhibitors (ALLINIs) have been of interest recently because of their novel mechanism of action. Strategic modifications to the C5 moiety of a class of 4-(4,4-dimethylpiperidinyl)-2,6-dimethylpyridinyl ALLI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ef219ff3295f925d0de0c18dbd1bec7
https://europepmc.org/articles/PMC9190037/
https://europepmc.org/articles/PMC9190037/
Autor:
B. Narasimhulu Naidu, Manoj Patel, Brian McAuliffe, Bo Ding, Christopher Cianci, Jean Simmermacher, Susan Jenkins, Dawn D. Parker, Prasanna Sivaprakasam, Javed A. Khan, Kevin Kish, Hal Lewis, Umesh Hanumegowda, Mark Krystal, Nicholas A. Meanwell, John F. Kadow
Publikováno v:
Journal of medicinal chemistry. 65(6)
Allosteric HIV-1 integrase inhibitors (ALLINIs) have garnered special interest because of their novel mechanism of action: they inhibit HIV-1 replication by promoting aberrant integrase multimerization, leading to the production of replication-defici
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3faa42431ce3f1fdb7932f28c2183dd4
https://pubmed.ncbi.nlm.nih.gov/35235334
https://pubmed.ncbi.nlm.nih.gov/35235334
Autor:
Tricia Protack, Michael A. Walker, Guo Li, David R. Langley, B. Narasimhulu Naidu, Nicholas A. Meanwell, George L. Trainor, Alicia Ng, Susan Jenkins, Mark Krystal, Zeyu Lin, Samuel Gerritz, Christopher Cianci, Hal A. Lewis, Kevin Kish, Javed Khan, Prasanna Sivaprakasam, Annapurna Pendri, Ira B. Dicker, Linda Discotto
Publikováno v:
Journal of Medicinal Chemistry. 63:2620-2637
The standard of care for HIV-1 infection, highly active antiretroviral therapy (HAART), combines two or more drugs from at least two classes. Even with the success of HAART, new drugs with novel mechanisms are needed to combat viral resistance, impro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c5678ae6d208f9b8ff19195b9eeed93
https://doi.org/10.1021/acs.jmedchem.9b01681
https://doi.org/10.1021/acs.jmedchem.9b01681
Autor:
Kyle Parcella, Manoj Patel, Yong Tu, Kyle Eastman, Kevin Peese, Eric Gillis, Ira Dicker, Brian McAuliffe, Bo Ding, Paul Falk, Jean Simmermacher, Dawn Parker, Prasanna Sivaprakasam, Javed Khan, Kevin Kish, Hal Lewis, Umesh Hanumegowda, Susan Jenkins, John Kadow, Mark Krystal, Nicholas Meanwell, B. Narasimhulu Naidu
Publikováno v:
SSRN Electronic Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb46a6a57e400e71e40d1517de5ec5cd
https://doi.org/10.2139/ssrn.4063473
https://doi.org/10.2139/ssrn.4063473
Autor:
Chunshan Xie, Qian Zhang, Anindya Sarkar, Joseph G. Naglich, Heng Cheng, Prasanna Sivaprakasam, Sanjeev Gangwar, Anushka C. Galasiti Kankanamalage, Dale L. Boger
Publikováno v:
Med Chem Res
A comprehensive SAR study of a putative TLR 3/8/9 agonist was conducted. Despite the excitement surrounding the potential of the first small molecule TLR3 agonist with a compound that additionally displayed agonist activity for TLR8 and TLR9, compoun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d364d59216dd425471435e4566507e53
https://pubmed.ncbi.nlm.nih.gov/34421287
https://pubmed.ncbi.nlm.nih.gov/34421287
Autor:
Eilene Kwok, Derwin Daniel W, Sanjeev Gangwar, Chin Pan, Chetana Rao, David Passmore, Yichong Wang, Bilal Sufi, David R. Langley, Pina M. Cardarelli, Vangipuram S. Rangan, Shrikant Deshpande, Gregory D. Vite, Naidu S. Chowdari, Prasanna Sivaprakasam
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:466-470
Uncialamycin analogs were evaluated as potential cytotoxic agents in an antibody-drug conjugate (ADC) approach to treating human cancer. These analogs were synthesized using Hauser annulations of substituted phthalides as a key step. A highly potent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aefe534a4de749455cd26d286d78d0f6
https://doi.org/10.1016/j.bmcl.2018.12.021
https://doi.org/10.1016/j.bmcl.2018.12.021