Design and testing of a microcontroller that enables alpha particle irradiators to deliver complex dose rate patterns

Autor: Alex S Rosen, Roger W. Howell, Akhil R Dondapati, Tomer Nawrocki, Prasad V.S.V. Neti, Thomas Tritt

Publikováno v: Phys Med Biol

There is increasing interest in using alpha particle emitting radionuclides for cancer therapy because of their unique cytotoxic properties which are advantageous for eradicating tumor cells. The high linear energy transfer (LET) of alpha particles p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b520e23b8319e202221d1cbc42ac7814
https://pubmed.ncbi.nlm.nih.gov/30524061

Radiation-induced reductions in transporter mRNA levels parallel reductions in intestinal sugar transport

Autor: Michael Brimacombe, Roger W. Howell, Edouard I. Azzam, Anjali Muduli, Francis W. Kemp, Ronaldo P. Ferraris, Alicia Attanasio, Edward Norkus, Marjolaine Roche, Amit Agrawal, Veronique Douard, Prasad V.S.V. Neti

Publikováno v: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 1 (298), R173-R182. (2010)
AJP-Regulatory, Integrative and Comparative Physiology
AJP-Regulatory, Integrative and Comparative Physiology, American Physiological Society, 2010, 298 (1), pp.R173-R182. ⟨10.1152/ajpregu.00612.2009⟩

More than a century ago, ionizing radiation was observed to damage the radiosensitive small intestine. Although a large number of studies has since shown that radiation reduces rates of intestinal digestion and absorption of nutrients, no study has d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c62966d9157ed01ea8f3b2901698274a
https://doi.org/10.1152/ajpregu.00612.2009

Biological Response to Nonuniform Distributions of210Po in Multicellular Clusters

Autor: Roger W. Howell, Prasad V.S.V. Neti

Publikováno v: Radiation Research. 168:332-340

Radionuclides are distributed nonuniformly in tissue. The present work examined the impact of nonuniformities at the multicellular level on the lethal effects of (210)Po. A three-dimensional (3D) tissue culture model was used wherein V79 cells were l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::420450c6c1fa0ea0a5e0e1d41bba0304
https://doi.org/10.1667/rr0902.1

High Levels of Dietary Supplement Vitamins A, C and E are Absorbed in the Small Intestine and Protect Nutrient Transport Against Chronic Gamma Irradiation

Autor: Francis W. Kemp, Roger W. Howell, Prasad V.S.V. Neti, Ronaldo P. Ferraris, Marjolaine Roche, Edouard I. Azzam

Publikováno v: Radiation research. 184(5)

We examined nutrient transport in the intestines of mice exposed to chronic low-LET 137Cs gamma rays. The mice were whole-body irradiated for 3 days at dose rates of 0, 0.13 and 0.20 Gy/h, for total dose delivery of 0, 9.6 or 14.4 Gy, respectively. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a212eafc25f1fac93fb6649b6eb146e1
https://pubmed.ncbi.nlm.nih.gov/26484399

Modeling Multicellular Response to Nonuniform Distributions of Radioactivity: Differences in Cellular Response to Self-Dose and Cross-Dose

Autor: Prasad V.S.V. Neti, Roger W. Howell

Publikováno v: Radiation Research. 163:216-221

Radiopharmaceuticals are distributed nonuniformly in tissue. While distributions of radioactivity often appear uniform at the organ level, in fact, microscopic examination reveals that only a fraction of the cells in tissue are labeled. Labeled cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5f5231ab7b78640bd4621ab8c5c3a8f
https://doi.org/10.1667/rr3290