Amerindian-specific regions under positive selection harbour new lipid variants in Latinos

Autor: Päivi Pajukanta, Niina Matikainen, Alejandra Rodriguez, Carlos A. Aguilar-Salinas, Johan G. Eriksson, Laura Riba, Marja-Riitta Taskinen, Matti Jauhiainen, Daphna Weissglas-Volkov, Olli T. Raitakari, Veikko Salomaa, Ivette Cruz Bautista, Rosario Rodríguez-Guillén, Janet S. Sinsheimer, Maribel Rodríguez-Torres, Robert Brown, Antti Jula, Rita M. Cantor, Marcus Alvarez, Elina Nikkola, Terho Lehtimäki, Markus Perola, Bogdan Pasaniuc, Prasad M. V. Linga Reddy, Olimpia Arellano-Campos, Teresa Tusie-Luna, Jaakko Kaprio, Kirk E. Lohmueller, Arthur Ko, Linda L. Muñoz-Hernández, Markku Heliövaara

Publikováno v: Nature communications, vol 5, iss 1
Ko, A; Cantor, RM; Weissglas-Volkov, D; Nikkola, E; Reddy, PMVL; Sinsheimer, JS; et al.(2014). Amerindian-specific regions under positive selection harbour new lipid variants in Latinos. Nature Communications, 5. doi: 10.1038/ncomms4983. UCLA: Retrieved from: http://www.escholarship.org/uc/item/5qf115w5
Nature Communications

Dyslipidemia and obesity are especially prevalent in populations with Amerindian backgrounds, such as Mexican–Americans, which predispose these populations to cardiovascular disease. Here we design an approach, known as the cross-population allele

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c3b205799f20f5af12101c1d5f46dc7
http://juuli.fi/Record/0253320414

STAT4 associates with systemic lupus erythematosus through two independent effects that correlate with gene expression and act additively with IRF5 to increase risk

Autor: Sergey V. Kozyrev, Ana Suárez, Prasad M V Linga Reddy, Sergio Migliaresi, Jérôme Wojcik, Hadi Abderrahim, Bernardo A. Pons-Estel, María Francisca González-Escribano, Javier Martín, Torsten Witte, Norberto Ortego-Centeno, Lorena Orozco, Marta E. Alarcón-Riquelme, Niclas Eriksson, Carmen Gutiérrez, Elena Sánchez, Sandra D'Alfonso, Vicente Baca, Angelica M. Delgado-Vega, Guadalupe Lima, Rafael Velázquez-Cruz, Anna-Karin Abelson

Publikováno v: ResearcherID

Objectives: To confirm and define the genetic association of STAT4 and systemic lupus erythematosus, investigate the possibility of correlations with differential splicing and/or expression levels, and genetic interaction with IRF5. Methods: 30 tag S

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28290d472cdf2eb2e8db7c2d8507a102
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=BIOSIS&KeyUT=BIOSIS:PREV200900627967&KeyUID=BIOSIS:PREV200900627967