Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Prasad Dandawate"'
Autor:
David Standing, Prasad Dandawate, Sumedha Gunewardena, Obdulia Covarrubias-Zambrano, Katherine F. Roby, Dineo Khabele, Andrea Jewell, Ossama Tawfik, Stefan H. Bossmann, Andrew K. Godwin, Scott J. Weir, Roy A. Jensen, Shrikant Anant
Publikováno v:
Cell Death and Disease, Vol 15, Iss 5, Pp 1-16 (2024)
Abstract Advanced epithelial ovarian cancer (EOC) survival rates are dishearteningly low, with ~25% surviving beyond 5 years. Evidence suggests that cancer stem cells contribute to acquired chemoresistance and tumor recurrence. Here, we show that IRA
Externí odkaz:
https://doaj.org/article/a34cd1f4ae354f69b2bfaed9395015fa
Autor:
Jingyi Ma, Dileepkumar Veeragoni, Hindole Ghosh, Nicole Mutter, Gisele Barbosa, Lauren Webster, Rainer Schobert, Wendy van de Sande, Prasad Dandawate, Bernhard Biersack
Publikováno v:
Biomedicines, Vol 12, Iss 7, p 1621 (2024)
The approved anthelmintic salicylanilide drug niclosamide has shown promising anticancer and antimicrobial activities. In this study, new niclosamide derivatives with trifluoromethyl, trifluoromethylsulfanyl, and pentafluorosulfanyl substituents repl
Externí odkaz:
https://doaj.org/article/b6f46fec24a64e0baa61fbfd34ba94b5
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2023)
Prolactin (PRL) is a peptide hormone mainly secreted from the anterior pituitary gland. PRL is reported to play a role in pregnancy, mammary gland development, immune modulation, reproduction, and differentiation of islet cells. PRL binds to its rece
Externí odkaz:
https://doaj.org/article/39314eb1c15c4fbe89a35ef0af1b9202
Publikováno v:
Pharmaceutics, Vol 15, Iss 7, p 1921 (2023)
Pancreatic carcinoma is a cancer disease with high mortality. Thus, new and efficient treatments for this disease are badly needed. Curcumin has previously shown promising effects in pancreatic cancer patients; however, this natural compound suffers
Externí odkaz:
https://doaj.org/article/6496dab7061a48e29fee709ff8caf30f
Fosciclopirox suppresses growth of high-grade urothelial cancer by targeting the γ-secretase complex
Autor:
Scott J. Weir, Prasad Dandawate, David Standing, Sangita Bhattacharyya, Prabhu Ramamoorthy, Parthasarathy Rangarajan, Robyn Wood, Amanda E. Brinker, Benjamin L. Woolbright, Mehmet Tanol, Tammy Ham, William McCulloch, Michael Dalton, Gregory A. Reed, Michael J. Baltezor, Roy A. Jensen, John A. Taylor, Shrikant Anant
Publikováno v:
Cell Death and Disease, Vol 12, Iss 6, Pp 1-20 (2021)
Abstract Ciclopirox (CPX) is an FDA-approved topical antifungal agent that has demonstrated preclinical anticancer activity in a number of solid and hematologic malignancies. Its clinical utility as an oral anticancer agent, however, is limited by po
Externí odkaz:
https://doaj.org/article/d4bbf6c8245447f1b012189797bdb6c4
Autor:
Dharmalingam Subramaniam, Pablo Angulo, Sivapriya Ponnurangam, Prasad Dandawate, Prabhu Ramamoorthy, Pugazhendhi Srinivasan, Tomoo Iwakuma, Scott J. Weir, Katherine Chastain, Shrikant Anant
Publikováno v:
Cell Death and Disease, Vol 11, Iss 2, Pp 1-15 (2020)
Abstract Osteosarcoma (OS) is the most common primary bone tumor that primarily affects children and adolescents. Studies suggested that dysregulation JAK/STAT signaling promotes the development of OS. Cells treated with pimozide, a STAT5 inhibitor s
Externí odkaz:
https://doaj.org/article/5d310a6efbe6464b9de53da6369710ad
Autor:
Dharmalingam Subramaniam, Sivapriya Ponnurangam, Satish Ramalingam, Deep Kwatra, Prasad Dandawate, Scott J. Weir, Shahid Umar, Roy A. Jensen, Shrikant Anant
Publikováno v:
Cells, Vol 10, Iss 7, p 1607 (2021)
Honokiol (HNK) is a biphenolic compound that has been used in traditional medicine for treating various ailments, including cancers. In this study, we determined the effect of HNK on colon cancer cells in culture and in a colitis-associated cancer mo
Externí odkaz:
https://doaj.org/article/e189357a54194781812e2f8d4d97ae49
Natural compounds targeting major cell signaling pathways: a novel paradigm for osteosarcoma therapy
Autor:
Pablo Angulo, Gaurav Kaushik, Dharmalingam Subramaniam, Prasad Dandawate, Kathleen Neville, Katherine Chastain, Shrikant Anant
Publikováno v:
Journal of Hematology & Oncology, Vol 10, Iss 1, Pp 1-13 (2017)
Abstract Osteosarcoma is the most common primary bone cancer affecting children and adolescents worldwide. Despite an incidence of three cases per million annually, it accounts for an inordinate amount of morbidity and mortality. While the use of che
Externí odkaz:
https://doaj.org/article/8f1e2e55df274950b74046abcf7a2849
Publikováno v:
Biomedicines, Vol 9, Iss 5, p 482 (2021)
Triple negative breast cancer (TNBC) is observed in ~15% of breast cancers and results in poor survival and increased distant metastases. Within the tumor are present a small portion of cancer stem cells that drive tumorigenesis and metastasis. In th
Externí odkaz:
https://doaj.org/article/e00b5ecb3ccb41c38f465e4665f7f9f4
Autor:
David Standing, Levi Arnold, Prasad Dandawate, Brendan Ottemann, Vusala Snyder, Sivapriya Ponnurangam, Afreen Sayed, Dharmalingam Subramaniam, Pugazhendhi Srinivasan, Sonali Choudhury, Jacob New, Deep Kwatra, Prabhu Ramamoorthy, Badal C. Roy, Melissa Shadoin, Raed Al‐Rajabi, Maura O'Neil, Sumedha Gunewardena, John Ashcraft, Shahid Umar, Scott J. Weir, Ossama Tawfik, Subhash B. Padhye, Bernhard Biersack, Shrikant Anant, Sufi Mary Thomas
Publikováno v:
Molecular Carcinogenesis. 62:145-159
Doublecortin like kinase 1 (DCLK1) plays a crucial role in several cancers including colon and pancreatic adenocarcinomas. However, its role in squamous cell carcinoma (SCC) remains unknown. To this end, we examined DCLK1 expression in head and neck
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fd9a55de8758a49d33e008a5ba3586e
https://doi.org/10.1002/mc.23472
https://doi.org/10.1002/mc.23472