Výsledky vyhledávání - "Prasad V. Chaturvedula"

Discovery of (R)-4-(8-fluoro-2-oxo-1,2-dihydroquinazolin-3(4H)-yl)-N-(3-(7-methyl-1H-indazol-5-yl)-1-oxo-1-(4-(piperidin-1-yl)piperidin-1-yl)propan-2-yl)piperidine-1-carboxamide (BMS-694153): a potent antagonist of the human calcitonin gene-related peptide receptor for migraine with rapid and efficient intranasal exposure

Autor: Andrew P, Degnan, Prasad V, Chaturvedula, Charles M, Conway, Deborah A, Cook, Carl D, Davis, Rex, Denton, Xiaojun, Han, Robert, Macci, Neil R, Mathias, Paul, Moench, Sokhom S, Pin, Shelly X, Ren, Richard, Schartman, Laura J, Signor, George, Thalody, Kimberly A, Widmann, Cen, Xu, John E, Macor, Gene M, Dubowchik

Publikováno v: Journal of medicinal chemistry. 51(16)

Calcitonin gene-related peptide (CGRP) has been implicated in the pathogenesis of migraine. Early chemistry leads suffered from modest potency, significant CYP3A4 inhibition, and poor aqueous solubility. Herein, we describe the optimization of these

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::26183be6c91d7db91dc9465dc6fe47a7
https://pubmed.ncbi.nlm.nih.gov/18665579

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