Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Prarthana Patil"'
Autor:
Ella N. Hoogenboezem, Shrusti S. Patel, Justin H. Lo, Ashley B. Cavnar, Lauren M. Babb, Nora Francini, Eva F. Gbur, Prarthana Patil, Juan M. Colazo, Danielle L. Michell, Violeta M. Sanchez, Joshua T. McCune, Jinqi Ma, Carlisle R. DeJulius, Linus H. Lee, Jonah C. Rosch, Ryan M. Allen, Larry D. Stokes, Jordan L. Hill, Kasey C. Vickers, Rebecca S. Cook, Craig L. Duvall
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract The high potential of siRNAs to silence oncogenic drivers remains largely untapped due to the challenges of tumor cell delivery. Here, divalent lipid-conjugated siRNAs are optimized for in situ binding to albumin to improve pharmacokinetics
Externí odkaz:
https://doaj.org/article/a8ad79f8d57c45aeac75fe1a848bd947
Autor:
Ella N. Hoogenboezem, Shrusti S. Patel, Ashley B. Cavnar, Justin H. Lo, Lauren M. Babb, Nora Francini, Prarthana Patil, Juan M. Colazo, Danielle L. Michell, Violeta M. Sanchez, Joshua T. McCune, Jinqi Ma, Carlisle R. DeJulius, Linus H. Lee, Jonah C. Rosch, Ryan M. Allen, Larry D. Stokes, Jordan L. Hill, Kasey C. Vickers, Rebecca S. Cook, Craig L. Duvall
Publikováno v:
bioRxiv
The high potential for therapeutic application of siRNAs to silence traditionally undruggable oncogenic drivers remains largely untapped due to the challenges of tumor cell delivery. Here, siRNAs were optimized forin situbinding to albumin through C1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed437d3b4e1884a99c1762f14a4e284b
https://doi.org/10.1101/2023.02.14.528574
https://doi.org/10.1101/2023.02.14.528574
Autor:
Prarthana Patil, Katherine A. Russo, Joshua T. McCune, Alonda C. Pollins, Matthew A. Cottam, Bryan R. Dollinger, Carlisle R. DeJulius, Mukesh K. Gupta, Richard D’Arcy, Juan M. Colazo, Fang Yu, Mariah G. Bezold, John R. Martin, Nancy L. Cardwell, Jeffrey M. Davidson, Callie M. Thompson, Adrian Barbul, Alyssa H. Hasty, Scott A. Guelcher, Craig L. Duvall
Publikováno v:
Sci Transl Med
Porous, resorbable biomaterials can serve as temporary scaffolds that support cell infiltration, tissue formation, and remodeling of nonhealing skin wounds. Synthetic biomaterials are less expensive to manufacture than biologic dressings and can achi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::986208244b0eeacb3190538537161e03
https://doi.org/10.1126/scitranslmed.abm6586
https://doi.org/10.1126/scitranslmed.abm6586
Autor:
Prarthana Patil, Joshua T. McCune, Alyssa M. Hasty, Katherine A. Russo, Matthew A. Cottam, Scott A. Guelcher, Bryan R. Dollinger, Adrian Barbul, Mukesh K. Gupta, John R. Martin, Jeffrey M. Davidson, Juan M. Colazo, Alonda C. Pollins, Fang Yu, Callie M Thompson, Craig L. Duvall, Nancy L. Cardwell
Impaired skin healing and progression into chronic wounds is a prevalent and growing medical problem. Porous, resorbable biomaterials can be used as temporary substrates placed into skin defects to support cell infiltration, neo-tissue formation, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::325ce2b0926d1008703b9720ffe81bbc
https://doi.org/10.1101/2021.05.21.445175
https://doi.org/10.1101/2021.05.21.445175
Autor:
Anne Panicker, Nadia Wager, Kathryn Sharratt, Rukmini Banerjee, Adele Jones, Prarthana Patil, Samantha J. Mason, Bhanu Varma
Publikováno v:
Child abuseneglect. 122
Background Child abuse and neglect (CAN) is a major public health concern, but limited data are available on the occurrence, co-occurrence, and correlates of these phenomena outside Western societies. Objectives The first aim of this study was to est
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::480daa5bc64a7a8ad21a2fb0714f89f2
https://pubmed.ncbi.nlm.nih.gov/34634525
https://pubmed.ncbi.nlm.nih.gov/34634525
Autor:
Evan B. Glass, Allyson R. King, Isom B. Kelly, Alyssa M. Hasty, Prarthana Patil, Todd D. Giorgio, Bryan R. Dollinger, Fang Yu, Sean K. Bedingfield, Rachel E. Miles, Shrusti S. Patel, Meredith A. Jackson, Danielle D. Liu, Ella N. Hoogenboezem, Craig L. Duvall, Matthew A. Cottam
Publikováno v:
Biomaterials
In vivonanocarrier-associated toxicity is a significant and poorly understood hurdle to clinical translation of siRNA nanomedicines. In this work, we demonstrate that platelet activating factor (PAF), an inflammatory lipid mediator, plays a key role
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbb5040a632bca16268a2cd1c732cd75
https://pubmed.ncbi.nlm.nih.gov/33285438
https://pubmed.ncbi.nlm.nih.gov/33285438
Publikováno v:
Biomaterials
Poly(ethylene glycol) (PEG) hydrogels crosslinked with enzyme-cleavable peptides are promising biodegradable vehicles for therapeutic cell delivery. However, peptide synthesis at the level required for bulk biomaterial manufacturing is costly, and fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e195b6567f39dbd7a1c54703b198de51
https://pubmed.ncbi.nlm.nih.gov/32947094
https://pubmed.ncbi.nlm.nih.gov/32947094
Autor:
Craig L. Duvall, Samantha M. Sarett, Lillian B. Nanney, Nancy L. Cardwell, Jeffrey M. Davidson, Alonda C. Pollins, John R. Martin, Scott A. Guelcher, Prarthana Patil
Publikováno v:
Tissue Engineering Part C: Methods. 23:754-762
Impaired wound healing that mimics chronic human skin pathologies is difficult to achieve in current animal models, hindering testing and development of new therapeutic biomaterials that promote wound healing. In this article, we describe a refinemen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f535d307acc00feda13412dd68f9006d
https://doi.org/10.1089/ten.tec.2017.0202
https://doi.org/10.1089/ten.tec.2017.0202
Publikováno v:
Advanced Materials Technologies. 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b190e0ba57aa4a93eea8f4f00c43808
https://doi.org/10.1002/admt.201670021
https://doi.org/10.1002/admt.201670021