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Proteogenomic integration reveals CXCL10 as a potentially downstream causal mediator for IL-6 signaling on atherosclerosis.

Autor: Prapiadou S; University of Patras School of Medicine, Patras, Greece.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Živković L; Institute for Stroke and Dementia Research, Ludwig-Maximilians-University of Munich, Munich, Germany., Thorand B; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, Germany., George MJ; Department of Clinical Pharmacology, Division of Medicine, University College London, London, United Kingdom., van der Laan SW; Central Diagnostics Laboratory, Division Laboratories, Pharmacy, and Biomedical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands., Malik R; Institute for Stroke and Dementia Research, Ludwig-Maximilians-University of Munich, Munich, Germany., Herder C; German Center for Diabetes Research, Partner Düsseldorf, Düsseldorf, Germany.; Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University, Düsseldorf, Germany.; Department of Endocrinology and Diabetology, Medical Faculty and University Hospital, Heinrich Heine University, Düsseldorf, Germany., Koenig W; German Centre for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany.; Institute of Epidemiology and Medical Biometry, University of Ulm, Ulm, Germany.; German Heart Center Munich, Technical University of Munich, Munich, Germany., Ueland T; Thrombosis Research Center (TREC), Division of internal medicine, University hospital of North Norway, Tromsø, Norway.; Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway.; Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Kleveland O; Clinic of Cardiology, St Olavs Hospital, Trondheim, Norway.; Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway., Aukrust P; Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway.; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Section of Clinical Immunology and Infectious Diseases, Oslo University Hospital Rikshospitalet, Oslo, Norway., Gullestad L; Department of Cardiology Oslo University Hospital Rikshospitalet, Oslo, Norway., Bernhagen J; Institute for Stroke and Dementia Research, Ludwig-Maximilians-University of Munich, Munich, Germany.; German Centre for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany., Pasterkamp G; Central Diagnostics Laboratory, Division Laboratories, Pharmacy, and Biomedical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands., Peters A; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, Germany.; Chair of Epidemiology, Institute for Medical Information Processing, Biometry, and Epidemiology, Ludwig-Maximilians-University Munich, Munich, Germany.; Munich Heart Alliance, German Center for Cardiovascular Health (DZHK e.V., partner-site Munich), Munich, Germany., Hingorani AD; Department of Clinical Pharmacology, Division of Medicine, University College London, London, United Kingdom.; Centre for Translational Genomics, Institute of Cardiovascular Science, University College London, London, United Kingdom., Rosand J; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Henry and Allison McCance Center for Brain Health, Massachusetts General Hospital, Boston, MA, USA., Dichgans M; Institute for Stroke and Dementia Research, Ludwig-Maximilians-University of Munich, Munich, Germany.; German Centre for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany.; Section of Clinical Immunology and Infectious Diseases, Oslo University Hospital Rikshospitalet, Oslo, Norway.; German Center for Neurodegenerative Diseases (DZNE, Munich), Munich, Germany., Anderson CD; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA., Georgakis MK; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Institute for Stroke and Dementia Research, Ludwig-Maximilians-University of Munich, Munich, Germany.

Publikováno v: MedRxiv : the preprint server for health sciences [medRxiv] 2023 Mar 28. Date of Electronic Publication: 2023 Mar 28.