Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Pranvera Sadiku"'
Autor:
Tyler Morrison, Ananda Mirchandani, Emily Watts, Patricia Coelho, Simone Arienti, Joseph Willison, Ailiang Zhang, Manuel Sanchez-Garcia, Pranvera Sadiku, Rebecca Dickinson, Fiona Murphy, Wesley Vermaelen, Amy Lewis, Massimilliano Mazzone, Peter Carmeliet, Christopher Pugh, Patrick Maxwell, Moira Whyte, David Dockrell, Bart Ghesquiere, Sarah Walmsley
Publikováno v:
Wellcome Open Research, Vol 8 (2024)
Background Neutrophils are essential in the early innate immune response to pathogens. Harnessing their antimicrobial powers, without driving excessive and damaging inflammatory responses, represents an attractive therapeutic possibility. The neutrop
Externí odkaz:
https://doaj.org/article/7f20aed589c94a37af77c1597c9f58e5
Autor:
Leila Reyes, Manuel A. Sanchez-Garcia, Tyler Morrison, Andy J. M. Howden, Emily R. Watts, Simone Arienti, Pranvera Sadiku, Patricia Coelho, Ananda S. Mirchandani, Ailiang Zhang, David Hope, Sarah K. Clark, Jo Singleton, Shonna Johnston, Robert Grecian, Azin Poon, Sarah McNamara, Isla Harper, Max Head Fourman, Alejandro J. Brenes, Shalini Pathak, Amy Lloyd, Giovanny Rodriguez Blanco, Alex von Kriegsheim, Bart Ghesquiere, Wesley Vermaelen, Camila T. Cologna, Kevin Dhaliwal, Nik Hirani, David H. Dockrell, Moira K. B. Whyte, David Griffith, Doreen A. Cantrell, Sarah R. Walmsley
Publikováno v:
Wellcome Open Research, Vol 6 (2021)
Background: Acute respiratory distress syndrome (ARDS) is a severe critical condition with a high mortality that is currently in focus given that it is associated with mortality caused by coronavirus disease 2019 (COVID-19). Neutrophils play a key ro
Externí odkaz:
https://doaj.org/article/69dfb1e9146244cb9d8db5194cef99af
Autor:
Leila Reyes, Manuel A. Sanchez-Garcia, Tyler Morrison, Andy J. M. Howden, Emily R. Watts, Simone Arienti, Pranvera Sadiku, Patricia Coelho, Ananda S. Mirchandani, Ailiang Zhang, David Hope, Sarah K. Clark, Jo Singleton, Shonna Johnston, Robert Grecian, Azin Poon, Sarah McNamara, Isla Harper, Max Head Fourman, Alejandro J. Brenes, Shalini Pathak, Amy Lloyd, Giovanny Rodriguez Blanco, Alex von Kriegsheim, Bart Ghesquiere, Wesley Vermaelen, Camila T. Cologna, Kevin Dhaliwal, Nik Hirani, David H. Dockrell, Moira K. B. Whyte, David Griffith, Doreen A. Cantrell, Sarah R. Walmsley
Publikováno v:
Wellcome Open Research, Vol 6 (2021)
Background: Acute respiratory distress syndrome (ARDS) is a severe critical condition with a high mortality that is currently in focus given that it is associated with mortality caused by coronavirus disease 2019 (COVID-19). Neutrophils play a key ro
Externí odkaz:
https://doaj.org/article/fdf252eb205a4660a9cdfc932717fe99
Autor:
Xingang Wang, Anne L. Robertson, Jingyu Li, Ruth Jinfen Chai, Wang Haishan, Pranvera Sadiku, Nikolay V. Ogryzko, Martin Everett, Kanagasundaram Yoganathan, Hongbo Robert Luo, Stephen A. Renshaw, Philip W. Ingham
Publikováno v:
Disease Models & Mechanisms, Vol 7, Iss 1, Pp 163-169 (2014)
Cell migration is fundamental to the inflammatory response, but uncontrolled cell migration and excess recruitment of neutrophils and other leukocytes can cause damage to the tissue. Here we describe the use of an in vivo model – the Tg(mpx:GFP)i11
Externí odkaz:
https://doaj.org/article/a8517d4267004992a957ba250976bbc1
Autor:
Eilise M. Ryan, Pranvera Sadiku, Patricia Coelho, Emily R. Watts, Ailiang Zhang, Andrew J. M. Howden, Manuel A. Sanchez-Garcia, Martin Bewley, Joby Cole, Brian J. McHugh, Wesley Vermaelen, Bart Ghesquiere, Peter Carmeliet, Giovanny Rodriguez Blanco, Alex Von Kriegsheim, Yolanda Sanchez, William Rumsey, James F. Callahan, George Cooper, Nicholas Parkinson, Kenneth Baillie, Doreen A. Cantrell, John McCafferty, Gourab Choudhury, Dave Singh, David H. Dockrell, Moira K. B. Whyte, Sarah R. Walmsley
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 207:998-1011
Rationale: Chronic obstructive pulmonary disease (COPD) is a disease characterized by persistent airway inflammation and disordered macrophage function. The extent to which alterations in macrophage bioenergetics contribute to impaired antioxidant re
Autor:
Ananda S. Mirchandani, Stephen J. Jenkins, Calum C. Bain, Manuel A. Sanchez-Garcia, Hannah Lawson, Patricia Coelho, Fiona Murphy, David M. Griffith, Ailiang Zhang, Tyler Morrison, Tony Ly, Simone Arienti, Pranvera Sadiku, Emily R. Watts, Rebecca. S. Dickinson, Leila Reyes, George Cooper, Sarah Clark, David Lewis, Van Kelly, Christos Spanos, Kathryn M. Musgrave, Liam Delaney, Isla Harper, Jonathan Scott, Nicholas J. Parkinson, Anthony J. Rostron, J. Kenneth Baillie, Sara Clohisey, Clare Pridans, Lara Campana, Philip Starkey Lewis, A. John Simpson, David H. Dockrell, Jürgen Schwarze, Nikhil Hirani, Peter J. Ratcliffe, Christopher W. Pugh, Kamil Kranc, Stuart J. Forbes, Moira K. B. Whyte, Sarah R. Walmsley
Publikováno v:
Mirchandani, A S, Jenkins, S J, Bain, C C, Sanchez Garcia, M A, Lawson, H, Coelho, P, Murphy, F, Griffith, D, Zhang, A, Morrison, T, Ly, T, Arienti, S, Sadiku, P, Watts, E R, Dickinson, R, Reyes, L, Cooper, G, Clark, S, Lewis, D, Kelly, V, Spanos, C, Musgrave, K M, Delaney, L, Harper, I, Scott, J, Parkinson, N, Rostron, A J, Baillie, J K, Clohisey, S, Pridans, C, Campana, L, Starkey Lewis, P, Simpson, A J, Dockrell, D H, Schwarze, J, Hirani, N, Ratcliffe, P J, Pugh, C W, Kranc, K, Forbes, S J, Whyte, M K B & Walmsley, S R 2022, ' Hypoxia shapes the immune landscape in lung injury and promotes the persistence of inflammation ', Nature Immunology . https://doi.org/0.1038/s41590-022-01216-z
Hypoxemia is a defining feature of acute respiratory distress syndrome (ARDS), an often-fatal complication of pulmonary or systemic inflammation, yet the resulting tissue hypoxia, and its impact on immune responses, is often neglected. In the present
Publikováno v:
Morrison, T, Watts, E R, Sadiku, P & Walmsley, S R 2022, ' The emerging role for metabolism in fueling neutrophilic inflammation ', Immunological reviews . https://doi.org/10.1111/imr.13157
Neutrophils are a critical element of host defence and are rapidly recruited to inflammatory sites. Such sites are frequently limited in oxygen and/or nutrient availability, presenting a metabolic challenge for infiltrating cells. Long believed to be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d90bfb505032b914f99eb5ac8f5caea4
https://www.pure.ed.ac.uk/ws/files/314246316/Published_Version.pdf
https://www.pure.ed.ac.uk/ws/files/314246316/Published_Version.pdf
Autor:
Ananda S. Mirchandani, Stephen J. Jenkins, Calum C. Bain, Hannah Lawson, Patricia Coelho, Fiona Murphy, David Griffith, Ailiang Zhang, Manuel A. Sanchez-Garcia, Leila Reyes, Tyler Morrison, Simone Arienti, Pranvera Sadiku, Emily R. Watts, Rebecca. S. Dickinson, Sarah Clark, Tony Ly, David Lewis, Van Kelly, Christos Spanos, Kathryn M. Musgrave, Liam Delaney, Isla Harper, Jonathan Scott, Nicholas J. Parkinson, Anthony J. Rostron, Kenneth J Baillie, Sara Clohisey, Clare Pridans, Lara Campana, Philip Starkey-Lewis, A John Simpson, David Dockrell, Jurgen Schwarze, Nikhil Hirani, Peter J. Ratcliffe, Christopher W. Pugh, Kamil Kranc, Stuart J. Forbes, Moira K. Whyte, Sarah R. Walmsley
Acute Respiratory Distress Syndrome (ARDS), an often-fatal complication of pulmonary or systemic inflammation, has no cure. Hypoxemia is a defining feature, yet its impact on inflammation is often neglected. Patients with ARDS are monocytopenic early
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd0c7273ae0a2fc5433d47bed192db4f
https://doi.org/10.1101/2022.03.11.483935
https://doi.org/10.1101/2022.03.11.483935
Autor:
Ananda S. Mirchandani, Stephen J. Jenkins, Calum C. Bain, Manuel A. Sanchez-Garcia, Hannah Lawson, Patricia Coelho, Fiona Murphy, David M. Griffith, Ailiang Zhang, Tyler Morrison, Tony Ly, Simone Arienti, Pranvera Sadiku, Emily R. Watts, Rebecca. S. Dickinson, Leila Reyes, George Cooper, Sarah Clark, David Lewis, Van Kelly, Christos Spanos, Kathryn M. Musgrave, Liam Delaney, Isla Harper, Jonathan Scott, Nicholas J. Parkinson, Anthony J. Rostron, J. Kenneth Baillie, Sara Clohisey, Clare Pridans, Lara Campana, Philip Starkey Lewis, A. John Simpson, David H. Dockrell, Jürgen Schwarze, Nikhil Hirani, Peter J. Ratcliffe, Christopher W. Pugh, Kamil Kranc, Stuart J. Forbes, Moira K. B. Whyte, Sarah R. Walmsley
Publikováno v:
Nature Immunology. 23:1394-1394
Autor:
Andrew J. M. Howden, Sarah R. Walmsley, Alex von Kriegsheim, Jens L. Hukelmann, Eilise M. Ryan, Rebecca S. Dickinson, Fiona Murphy, Gio Rodriguez Blanco, Bart Ghesquière, Patrícia Coelho, Doreen A. Cantrell, Emily R. Watts, Pranvera Sadiku, Robert Grecian, Ananda S. Mirchandani, Wesley Vermaelen, Tyler Morrison, Duncan Humphries, Tracie Plant, Moira K. B. Whyte, Andrew J. Finch
Publikováno v:
Watts, E R, Howden, A J M, Morrison, T, Sadiku, P, Hukelmann, J L, Von Kriegsheim, A, Ghesquière, B, Murphy, F, Mirchandani, A S, Humphries, D C, Grecian, R, Ryan, E M, Coelho, P, Rodriguez-blanco, G, Plant, T M, Dickinson, R S, Finch, A J, Vermaelen, W, Cantrell, D A, Whyte, M K B & Walmsley, S R 2021, ' Hypoxia drives murine neutrophil protein scavenging to maintain central carbon metabolism ', Journal of Clinical Investigation . https://doi.org/10.1172/JCI134073
Limiting dysfunctional neutrophilic inflammation while preserving effective immunity requires a better understanding of the processes that dictate neutrophil function in the tissues. Quantitative mass-spectrometry identified how inflammatory murine n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58a5393e0379a24b90ce692f5f16f351
https://hdl.handle.net/20.500.11820/6ee67df8-79e3-477f-a412-02d6f22765b7
https://hdl.handle.net/20.500.11820/6ee67df8-79e3-477f-a412-02d6f22765b7