Free Bilirubin Induces Neuro-Inflammation in an Induced Pluripotent Stem Cell-Derived Cortical Organoid Model of Crigler-Najjar Syndrome.

Autor: Pranty, Abida Islam¹ (AUTHOR) abida.pranty@hhu.de, Wruck, Wasco¹ (AUTHOR) wasco.wruck@med.uni-duesseldorf.de, Adjaye, James^1,2 (AUTHOR) james.adjaye@med.uni-duesseldorf.de

Publikováno v: Cells (2073-4409). Sep2023, Vol. 12 Issue 18, p2277. 19p.

SARS-CoV-2 targets neurons of 3D human brain organoids

Autor: Henning Gruell, Heiner Schaal, Sandra Hauka, Pranty Abida‐Islam, Kai Wohlgemuth, Anand Ramani, Aruljothi Mariappan, Jörg Timm, Jay Gopalakrishnan, Elke Gabriel, Lisa Müller, Olivier Goureau, Carsten Korth, Dagmar Wieczorek, Alexander T. Dilthey, Torsten Houwaart, Ortwin Adams, Florian Klein, Heymut Omran, Philipp Niklas Ostermann, Marcel Andree, Andreas Müller-Schiffmann, Andreas Walker

Publikováno v: EMBO Journal
EMBO Journal, EMBO Press, 2020, 39 (20), pp.e106230. ⟨10.15252/embj.2020106230⟩
The EMBO Journal

COVID‐19 pandemic caused by SARS‐CoV‐2 infection is a public health emergency. COVID‐19 typically exhibits respiratory illness. Unexpectedly, emerging clinical reports indicate that neurological symptoms continue to rise, suggesting detriment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::822893f7c59f44ba10ecc22759c5b9e1
https://hal.archives-ouvertes.fr/hal-02969415/document

Hemozoin induces malaria via activation of DNA damage, p38 MAPK and neurodegenerative pathways in a human iPSC-derived neuronal model of cerebral malaria.

Autor: Pranty AI; Institute for Stem Cell Research and Regenerative Medicine, Medical Faculty, Heinrich-Heine University, 40225, Düsseldorf, Germany., Szepanowski LP; Institute for Stem Cell Research and Regenerative Medicine, Medical Faculty, Heinrich-Heine University, 40225, Düsseldorf, Germany., Wruck W; Institute for Stem Cell Research and Regenerative Medicine, Medical Faculty, Heinrich-Heine University, 40225, Düsseldorf, Germany., Karikari AA; Department of Biomedical Sciences, School of Allied Health Sciences, College of Health and Allied Sciences, University of Cape Coast, Cape Coast, Ghana., Adjaye J; Institute for Stem Cell Research and Regenerative Medicine, Medical Faculty, Heinrich-Heine University, 40225, Düsseldorf, Germany. james.adjaye@med.uni-duesseldorf.de.; Zayed Centre for Research into Rare Diseases in Children (ZCR), University College London - EGA Institute for Women's Health, 20 Guilford Street, WC1N 1DZ, London, United Kingdom. james.adjaye@med.uni-duesseldorf.de.

Publikováno v: Scientific reports [Sci Rep] 2024 Oct 23; Vol. 14 (1), pp. 24959. Date of Electronic Publication: 2024 Oct 23.