Vaginal microbiome-host interactions modeled in a human vagina-on-a-chip.

Autor: Mahajan G; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, 02115, USA.; Present address: Emulate, Inc, 27 Drydock Ave, Boston, MA, 02210, USA., Doherty E; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, 02115, USA., To T; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, 02115, USA., Sutherland A; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, 02115, USA., Grant J; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, 02115, USA., Junaid A; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, 02115, USA., Gulati A; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, 02115, USA., LoGrande N; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, 02115, USA., Izadifar Z; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, 02115, USA., Timilsina SS; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, 02115, USA., Horváth V; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, 02115, USA., Plebani R; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, 02115, USA.; Present address: Center on Advanced Studies and Technology, Department of Medical, Oral and Biotechnological Sciences, G. d'Annunzio, University of Chieti-Pescara, Chieti, Italy., France M; Institute for Genome Sciences and Department of Microbiology & Immunology, University of Maryland School of Medicine, Baltimore, MD, USA., Hood-Pishchany I; Division of Infectious Diseases and Division of Gastroenterology, Department of Pediatrics, Boston Children's Hospital and Harvard Medical School, 300 Longwood Avenue, Boston, Massachusetts, 02115, USA., Rakoff-Nahoum S; Division of Infectious Diseases and Division of Gastroenterology, Department of Pediatrics, Boston Children's Hospital and Harvard Medical School, 300 Longwood Avenue, Boston, Massachusetts, 02115, USA., Kwon DS; Ragon Institute of MGH, MIT, and Harvard, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA., Goyal G; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, 02115, USA., Prantil-Baun R; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, 02115, USA., Ravel J; Institute for Genome Sciences and Department of Microbiology & Immunology, University of Maryland School of Medicine, Baltimore, MD, USA., Ingber DE; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, 02115, USA. don.ingber@wyss.harvard.edu.; Vascular Biology Program and Department of Surgery, Boston Children's Hospital and Harvard Medical School, Boston, MA, 02115, USA. don.ingber@wyss.harvard.edu.; Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, 02139, USA. don.ingber@wyss.harvard.edu.

Publikováno v: Microbiome [Microbiome] 2022 Nov 26; Vol. 10 (1), pp. 201. Date of Electronic Publication: 2022 Nov 26.

Differential ABC transporter expression during hematopoiesis contributes to neutrophil-biased toxicity of Aurora kinase inhibitors.

Autor: Chou DB; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA.; Department of Pathology, Massachusetts General Hospital, Boston, MA, USA., Furlong BA; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA., Posey RR; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA., Kyprianou C; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA., O'Sullivan LR; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA., David R; Safety Sciences, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge, UK., Randle SJ; Safety Sciences, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge, UK., Polanska UM; Early Oncology, R&D, AstraZeneca, Cambridge, UK., Travers J; Early Oncology, R&D, AstraZeneca, Cambridge, UK., Urosevic J; Early Oncology, R&D, AstraZeneca, Cambridge, UK., Hutchinson JN; Harvard Chan Bioinformatics Core, Boston, MA, USA., Che J; Department of Cancer Biology, Dana-Farber Cancer Institute, and Department of Biological Chemistry & Molecular Pharmacology, Harvard Medical School, Boston, MA, USA., Howley AM; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA., Hasserjian RP; Department of Pathology, Massachusetts General Hospital, Boston, MA, USA., Prantil-Baun R; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA., Ingber DE; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA. don.ingber@wyss.harvard.edu.; Vascular Biology Program and Department of Surgery, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA. don.ingber@wyss.harvard.edu.; Harvard John A. Paulson School of Engineering and Applied Sciences, Boston, MA, USA. don.ingber@wyss.harvard.edu.

Publikováno v: Nature communications [Nat Commun] 2022 Oct 12; Vol. 13 (1), pp. 6021. Date of Electronic Publication: 2022 Oct 12.

Modeling pulmonary cystic fibrosis in a human lung airway-on-a-chip.

Autor: Plebani R; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, United States; Center on Advanced Studies and Technology (CAST), Department of Medical, Oral and Biotechnological Sciences, 'G. d'Annunzio' University of Chieti-Pescara, Chieti, Italy., Potla R; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, United States; Vascular Biology Program and Department of Surgery, Boston Children's Hospital and Harvard Medical School, Boston, MA, United States., Soong M; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, United States., Bai H; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, United States., Izadifar Z; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, United States., Jiang A; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, United States., Travis RN; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, United States., Belgur C; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, United States., Dinis A; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, United States., Cartwright MJ; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, United States., Prantil-Baun R; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, United States., Jolly P; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, United States., Gilpin SE; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, United States., Romano M; Center on Advanced Studies and Technology (CAST), Department of Medical, Oral and Biotechnological Sciences, 'G. d'Annunzio' University of Chieti-Pescara, Chieti, Italy., Ingber DE; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, United States; Vascular Biology Program and Department of Surgery, Boston Children's Hospital and Harvard Medical School, Boston, MA, United States; Harvard John A. Paulson School of Engineering and Applied Sciences, Cambridge, MA, United States. Electronic address: don.ingber@wyss.harvard.edu.

Publikováno v: Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society [J Cyst Fibros] 2022 Jul; Vol. 21 (4), pp. 606-615. Date of Electronic Publication: 2021 Nov 17.

Establishment of physiologically relevant oxygen gradients in microfluidic organ chips.

Autor: Grant J; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA. don.ingber@wyss.harvard.edu., Lee E; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA. don.ingber@wyss.harvard.edu., Almeida M; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA. don.ingber@wyss.harvard.edu., Kim S; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA. don.ingber@wyss.harvard.edu., LoGrande N; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA. don.ingber@wyss.harvard.edu., Goyal G; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA. don.ingber@wyss.harvard.edu., Sesay AM; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA. don.ingber@wyss.harvard.edu., Breault DT; Division of Endocrinology, Boston Children's Hospital, Boston, MA 02115, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA, 02115, USA.; Harvard Stem Cell Institute, Harvard University, Boston, MA 02139, USA., Prantil-Baun R; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA. don.ingber@wyss.harvard.edu., Ingber DE; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA. don.ingber@wyss.harvard.edu.; Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA.; Vascular Biology Program and Department of Surgery, Harvard Medical School and Boston Children's Hospital, Boston, MA 02115, USA.

Publikováno v: Lab on a chip [Lab Chip] 2022 Apr 12; Vol. 22 (8), pp. 1584-1593. Date of Electronic Publication: 2022 Apr 12.

Robotic fluidic coupling and interrogation of multiple vascularized organ chips.

Autor: Novak R; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA., Ingram M; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA., Marquez S; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA., Das D; CFD Research Corporation, Huntsville, AL, USA., Delahanty A; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA., Herland A; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA.; Division of Micro and Nanosystems, KTH Royal Institute of Technology, Stockholm, Sweden., Maoz BM; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA.; Disease Biophysics Group, Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA.; Department of Biomedical Engineering and Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel., Jeanty SSF; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA.; Emulate, Inc., Boston, MA, USA., Somayaji MR; CFD Research Corporation, Huntsville, AL, USA., Burt M; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA., Calamari E; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA., Chalkiadaki A; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA., Cho A; CFD Research Corporation, Huntsville, AL, USA., Choe Y; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA., Chou DB; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA.; Department of Pathology, Massachusetts General Hospital, Boston, MA, USA., Cronce M; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA., Dauth S; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA.; Disease Biophysics Group, Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA., Divic T; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA., Fernandez-Alcon J; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA.; Emulate, Inc., Boston, MA, USA., Ferrante T; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA., Ferrier J; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA.; Disease Biophysics Group, Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA., FitzGerald EA; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA., Fleming R; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA., Jalili-Firoozinezhad S; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA.; Department of Bioengineering and iBB-Institute for Bioengineering and Biosciences, Instituto Superior Técnico, Universidade de Lisboa, Lisboa, Portugal., Grevesse T; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA.; Disease Biophysics Group, Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA., Goss JA; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA.; Disease Biophysics Group, Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA., Hamkins-Indik T; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA., Henry O; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA., Hinojosa C; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA.; Emulate, Inc., Boston, MA, USA., Huffstater T; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA., Jang KJ; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA.; Emulate, Inc., Boston, MA, USA., Kujala V; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA.; Disease Biophysics Group, Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA.; Emulate, Inc., Boston, MA, USA., Leng L; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA.; Emulate, Inc., Boston, MA, USA., Mannix R; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA.; Vascular Biology Program and Department of Surgery, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA., Milton Y; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA., Nawroth J; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA.; Disease Biophysics Group, Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA.; Emulate, Inc., Boston, MA, USA., Nestor BA; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA., Ng CF; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA., O'Connor B; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA.; Disease Biophysics Group, Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA., Park TE; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA., Sanchez H; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA., Sliz J; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA.; Emulate, Inc., Boston, MA, USA., Sontheimer-Phelps A; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA.; Department of Biology, University of Freiburg, Freiburg, Germany., Swenor B; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA., Thompson G 2nd; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA.; Emulate, Inc., Boston, MA, USA., Touloumes GJ; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA.; Disease Biophysics Group, Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA., Tranchemontagne Z; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA., Wen N; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA.; Emulate, Inc., Boston, MA, USA., Yadid M; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA.; Disease Biophysics Group, Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA., Bahinski A; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA.; GlaxoSmithKline, Collegeville, PA, USA., Hamilton GA; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA.; Emulate, Inc., Boston, MA, USA., Levner D; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA.; Emulate, Inc., Boston, MA, USA., Levy O; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA., Przekwas A; CFD Research Corporation, Huntsville, AL, USA., Prantil-Baun R; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA., Parker KK; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA.; Disease Biophysics Group, Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA., Ingber DE; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA. don.ingber@wyss.harvard.edu.; Vascular Biology Program and Department of Surgery, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA. don.ingber@wyss.harvard.edu.; Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA. don.ingber@wyss.harvard.edu.

Publikováno v: Nature biomedical engineering [Nat Biomed Eng] 2020 Apr; Vol. 4 (4), pp. 407-420. Date of Electronic Publication: 2020 Jan 27.