Zobrazeno 1 - 7 of 7 pro vyhledávání: '"Pranika Singh"'
1
Capturing time-dependent activation of genes and stress-response pathways using transcriptomics in iPSC-derived renal proximal tubule cells
Autor: Paul Jennings, Giada Carta, Pranika Singh, Daniel da Costa Pereira, Anita Feher, Andras Dinnyes, Thomas E. Exner, Anja Wilmes
Publikováno v: Jennings, P, Jennings, P, Singh, P, da Costa Pereira, D, Feher, A, Dinnyes, A, Exner, T E & Wilmes, A 2022, ' Capturing time-dependent activation of genes and stress-response pathways using transcriptomics in iPSC-derived renal proximal tubule cells ', Cell biology and toxicology . https://doi.org/10.1007/s10565-022-09783-5
Cell biology and toxicology. Springer Netherlands
Transcriptomic analysis is a powerful method in the utilization of New Approach Methods (NAMs) for identifying mechanisms of toxicity and application to hazard characterization. With this regard, mapping toxicological events to time of exposure would
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7626ff9d6b35df57d0acbec77d2cc02a
https://pubmed.ncbi.nlm.nih.gov/36586010
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2
An in vitro strategy using multiple human induced pluripotent stem cell-derived models to assess the toxicity of chemicals: A case study on paraquat
Autor: Carolina Nunes, Pranika Singh, Zahra Mazidi, Cormac Murphy, Aurore Bourguignon, Sara Wellens, Vidya Chandrasekaran, Sreya Ghosh, Melinda Zana, David Pamies, Aurélien Thomas, Catherine Verfaillie, Maxime Culot, Andras Dinnyes, Barry Hardy, Anja Wilmes, Paul Jennings, Regina Grillari, Johannes Grillari, Marie-Gabrielle Zurich, Thomas Exner
Publikováno v: Nunes, C, Singh, P, Mazidi, Z, Murphy, C, Bourguignon, A, Wellens, S, Chandrasekaran, V, Ghosh, S, Zana, M, Pamies, D, Thomas, A, Verfaillie, C, Culot, M, Dinnyes, A, Hardy, B, Wilmes, A, Jennings, P, Grillari, R, Grillari, J, Zurich, M-G & Exner, T 2022, ' An in vitro strategy using multiple human induced pluripotent stem cell-derived models to assess the toxicity of chemicals : A case study on paraquat ', Toxicology in Vitro, vol. 81, 105333, pp. 1-16 . https://doi.org/10.1016/j.tiv.2022.105333
Toxicology in vitro, vol. 81, pp. 105333
Toxicology in Vitro, 81:105333, 1-16. Elsevier Limited
Most OECD guidelines for chemical risk assessment include tests performed on animals, raising financial, ethical and scientific concerns. Thus, the development of human-based models for toxicity testing is highly encouraged. Here, we propose an in vi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28278d25bd8c3b61f5b6482e91644fb6
https://lirias.kuleuven.be/handle/20.500.12942/697398
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3
How to Foster 'New Approach Methodology' Toxicologists
Autor: Tatyana Y. Doktorova, Pamela Azzi, Joelle Hofer, Catherine J. Messner, Carine Gaiser, Sophie Werner, Pranika Singh, Barry Hardy, Laura Suter-Dick, Christophe Chesne
Publikováno v: Alternatives to laboratory animals : ATLA. 50(1)
The need to reduce, refine and replace animal experimentation has led to a boom in the establishment of new approach methodologies (NAMs). This promising trend brings the hope that the replacement of animals by using NAMs will become increasingly acc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5670c7f8432c71098b02010543f5f33a
https://pubmed.ncbi.nlm.nih.gov/35179997
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4
Temporal transcriptomic alterations of cadmium exposed human iPSC-derived renal proximal tubule-like cells
Autor: Barry Hardy, Paul Jennings, Pranika Singh, Anja Wilmes, Thomas Exner, Vidya Chandrasekaran
Publikováno v: Toxicology in Vitro, 76:105229, 1-13. Elsevier Limited
Singh, P, Chandrasekaran, V, Hardy, B, Wilmes, A, Jennings, P & Exner, T E 2021, ' Temporal transcriptomic alterations of cadmium exposed human iPSC-derived renal proximal tubule-like cells ', Toxicology in Vitro, vol. 76, 105229, pp. 1-13 . https://doi.org/10.1016/j.tiv.2021.105229
Toxicology in Vitro
Cadmium is a well-studied environmental pollutant where the kidney and particularly the proximal tubule cells are especially sensitive as they are exposed to higher concentrations of cadmium than other tissues. Here we investigated the temporal trans
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dec87d4b3f7e27ae78f3c960f92ead7
https://pubmed.ncbi.nlm.nih.gov/34352368
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6
Evaluation of a human iPSC-derived BBB model for repeated dose toxicity testing with cyclosporine A as model compound
Autor: Rodrigo Azevedo Loiola, Sara Wellens, Fabien Gosselet, Emmanuel Sevin, Pranika Singh, Paul Jennings, Thomas Exner, Lucie Dehouck, Maxime Culot, Vidya Chandrasekaran
Publikováno v: Wellens, S, Dehouck, L, Chandrasekaran, V, Singh, P, Loiola, R A, Sevin, E, Exner, T, Jennings, P, Gosselet, F & Culot, M 2021, ' Evaluation of a human iPSC-derived BBB model for repeated dose toxicity testing with cyclosporine A as model compound ', Toxicology in Vitro, vol. 73, 105112 . https://doi.org/10.1016/j.tiv.2021.105112
Toxicology in Vitro, 73:105112. Elsevier Limited
Toxicology in Vitro
Toxicology in Vitro, Elsevier, 2021, 73, pp.105112. ⟨10.1016/j.tiv.2021.105112⟩
International audience; The blood-brain barrier (BBB) is a highly restrictive barrier that preserves central nervous system homeostasis and ensures optimal brain functioning. Using BBB cell assays makes it possible to investigate whether a compound i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d2b265dcd979e31d10c0d2bb845fde0
https://pubmed.ncbi.nlm.nih.gov/33631201
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