Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Pranavanand, Nyshadham"'
Autor:
Ravikumar Jimmidi, Srinivas Chamakuri, Shuo Lu, Melek Nihan Ucisik, Peng-Jen Chen, Kurt M. Bohren, Seyed Arad Moghadasi, Leroy Versteeg, Christina Nnabuife, Jian-Yuan Li, Xuan Qin, Ying-Chu Chen, John C. Faver, Pranavanand Nyshadham, Kiran L. Sharma, Banumathi Sankaran, Allison Judge, Zhifeng Yu, Feng Li, Jeroen Pollet, Reuben S. Harris, Martin M. Matzuk, Timothy Palzkill, Damian W. Young
Publikováno v:
Communications Chemistry, Vol 6, Iss 1, Pp 1-10 (2023)
Abstract The development of SARS-CoV-2 main protease (Mpro) inhibitors for the treatment of COVID-19 has mostly benefitted from X-ray structures and preexisting knowledge of inhibitors; however, an efficient method to generate Mpro inhibitors, which
Externí odkaz:
https://doaj.org/article/aab44f4c21884a5ab19d7b954a87359d
Autor:
Xuan Qin, Stephen Palmer, Mercedes Barzi, Pranavanand Nyshadham, Sung Yun Jung, Karl-Dimiter Bissig, Joie Guner, Martin M. Matzuk, John M. Hakenjos, Si Chen, Kevin R. MacKenzie, Hemantkumar Chavan, Partha Krishnamurthy, Jin Wang, Lei Guo, Feng Li
Publikováno v:
Drug Metabolism and Disposition. 50:128-139
Duloxetine (DLX) is a dual serotonin and norepinephrine reuptake inhibitor, widely used for the treatment of major depressive disorder. Although DLX has shown good efficacy and safety, serious adverse effects (e.g., liver injury) have been reported.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d9ccca6d77ac68a2616551432aa4aa9
https://doi.org/10.1124/dmd.121.000633
https://doi.org/10.1124/dmd.121.000633
Autor:
Ram K. Modukuri, Zhifeng Yu, Zhi Tan, Hai Minh Ta, Melek Nihan Ucisik, Zhuang Jin, Justin L. Anglin, Kiran L. Sharma, Pranavanand Nyshadham, Feng Li, Kevin Riehle, John C. Faver, Kevin Duong, Sureshbabu Nagarajan, Nicholas Simmons, Stephen S. Palmer, Mingxing Teng, Damian W. Young, Joanna S. Yi, Choel Kim, Martin M. Matzuk
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(22)
BRDT, BRD2, BRD3, and BRD4 comprise the bromodomain and extraterminal (BET) subfamily which contain two similar tandem bromodomains (BD1 and BD2). Selective BD1 inhibition phenocopies effects of tandem BET BD inhibition both in cancer models and, as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79a851d4e692ff7c8340bbbd30abba30
https://pubmed.ncbi.nlm.nih.gov/35622893
https://pubmed.ncbi.nlm.nih.gov/35622893
Autor:
Xuan Qin, Cen Xie, John M. Hakenjos, Kevin M. Mackenzie, Mercedes Barzi, Pranavanand Nyshadham, Saleh M. Khalil, Karl‐Dimiter Bissig, Frank J. Gonzalez, Martin M. Matzuk, Feng Li
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::38ad9155d0bf21635a02cf4404dd1e80
https://doi.org/10.1096/fasebj.2022.36.s1.l7654
https://doi.org/10.1096/fasebj.2022.36.s1.l7654
Autor:
Surendra Dawadi, Gabriella Miklossy, Nicholas Simmons, Martin M. Matzuk, Zhifeng Yu, Melek N. Ucisik, Pranavanand Nyshadham, Kurt M. Bohren, John C. Faver
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance To rapidly identify small-molecule lead compounds to target healthcare-associated proteases, we constructed a unique 9.8-million-membered protease-focused DNA-encoded chemical library. Affinity selection of this library with a healthcare
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d02ebab15c77095173718e34457e534
https://doi.org/10.1073/pnas.2005447117
https://doi.org/10.1073/pnas.2005447117
Autor:
Martin M. Matzuk, Banumathi Sankaran, Timothy Palzkill, Nicholas Simmons, Zhuang Jin, Feng Li, Liya Hu, Murugesan Palaniappan, Suhyeorn Park, Pranavanand Nyshadham, Justin L. Anglin, Doris Mia Taylor, B. V. Venkataram Prasad, Hongbing Huang, James C. Campbell, Melek N. Ucisik, John C. Faver
Publikováno v:
ACS Infect Dis
Bacterial resistance to β-lactam antibiotics is largely mediated by β-lactamases, which catalyze the hydrolysis of these drugs and continue to emerge in response to antibiotic use. β-lactamases that hydrolyze the last resort carbapenem class of β
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5483a95bd1072afdf4b9516bb8755ca
https://doi.org/10.1021/acsinfecdis.0c00015
https://doi.org/10.1021/acsinfecdis.0c00015
Homogeneous and Functional Group Tolerant Ring-Closing Metathesis for DNA-Encoded Chemical Libraries
Autor:
Pranavanand Nyshadham, Damian W. Young, Martin M. Matzuk, Kurt M. Bohren, Nicholas Simmons, Murugesan Palaniappan, Olivier B. C. Monty
Publikováno v:
ACS Combinatorial Science
Reaction heterogeneity, poor pH control, and catalyst decomposition in the ring-closing metathesis (RCM) of DNA–chemical conjugates lead to poor yields of the cyclized products. Herein we address these issues with a RCM reaction system that include
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5eebf1ffd0f5101abda5ae2f2ebca0d5
https://doi.org/10.1021/acscombsci.9b00199
https://doi.org/10.1021/acscombsci.9b00199
Autor:
Srinivas, Chamakuri, Shuo, Lu, Melek Nihan, Ucisik, Kurt M, Bohren, Ying-Chu, Chen, Huang-Chi, Du, John C, Faver, Ravikumar, Jimmidi, Feng, Li, Jian-Yuan, Li, Pranavanand, Nyshadham, Stephen S, Palmer, Jeroen, Pollet, Xuan, Qin, Shannon E, Ronca, Banumathi, Sankaran, Kiran L, Sharma, Zhi, Tan, Leroy, Versteeg, Zhifeng, Yu, Martin M, Matzuk, Timothy, Palzkill, Damian W, Young
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance SARS-CoV-2 has had a crippling impact on human life globally. Vaccine development has been used as a first-line strategy for COVID-19 prevention and mitigation; however, small-molecule drugs are still vitally needed to extend treatment o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::15cb54546b7f4431aeba52ef806a07ae
https://pubmed.ncbi.nlm.nih.gov/34426525
https://pubmed.ncbi.nlm.nih.gov/34426525
Autor:
Ravikumar Jimmidi, Kurt M. Bohren, Jeroen Pollet, Xuan Qin, Shannon E. Ronca, Timothy Palzkill, Shuo Lu, Zhifeng Yu, Damian W. Young, Srinivas Chamakuri, Zhi Tan, Ying-Chu Chen, Melek N. Ucisik, Feng Li, John C. Faver, J. Li, Stephen Palmer, Kiran L. Sharma, Martin M. Matzuk, Banumathi Sankaran, Huang-Chi Du, Leroy Versteeg, Pranavanand Nyshadham
Publikováno v:
Proceedings of the National Academy of Sciences. 118
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has killed more than 4 million humans globally, but there is no bona fide Food and Drug Administration-approved drug-like molecule to impede the COVID-19 pandemic. The sluggish pace of trad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a995856c9d6262ef493039a76779d55a
https://doi.org/10.1073/pnas.2111172118
https://doi.org/10.1073/pnas.2111172118
Autor:
Justin L. Anglin, Kevin Riehle, John C. Faver, Marta Storl-Desmond, Rajesh Sharma, Damian W. Young, Melek N. Ucisik, Gundeep Kaur, Feng Li, Choel Kim, Kiran L. Sharma, Nicholas Simmons, Zhifeng Yu, Sureshbabu Nagarajan, Martin M. Matzuk, Pranavanand Nyshadham, Stephen Palmer, Banumathi Sankaran, Angela F. Ku
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 118, iss 9
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America
Significance There is no nonhormonal contraceptive pill for men, although hundreds of genes have been identified to play roles during spermatogenesis and fertilization in the male reproductive tract. To address the absence of contraceptive drugs for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a47b29b36c4d8ecbdaff9fff6156c7c
https://escholarship.org/uc/item/9t49g9fr
https://escholarship.org/uc/item/9t49g9fr
