Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Pranati Samadder"'
Autor:
Amani I. Moraya, Jennifer L. Ali, Pranati Samadder, Lisa Liang, Ludivine Coudière Morrison, Tamra E. Werbowetski-Ogilvie, Makanjuola Ogunsina, Frank Schweizer, Gilbert Arthur, Mark W. Nachtigal
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 36, Iss 1, Pp 1-13 (2017)
Abstract Background Chemotherapy resistance is one of the major factors contributing to mortality from human epithelial ovarian cancer (EOC). Identifying drugs that can effectively kill chemotherapy-resistant EOC cells would be a major advance in red
Externí odkaz:
https://doaj.org/article/4d674fe80e4341f18add9d702a408c48
Autor:
Makanjuola Ogunsina, Pranati Samadder, Temilolu Idowu, Mark Nachtigal, Frank Schweizer, Gilbert Arthur
Publikováno v:
Molecules, Vol 25, Iss 3, p 566 (2020)
A major impediment to successful cancer treatment is the inability of clinically available drugs to kill drug-resistant cancer cells. We recently identified metabolically stable l-glucosamine-based glycosylated antitumor ether lipids (GAELs) that wer
Externí odkaz:
https://doaj.org/article/d19affeed2994b37906d0652e9810e13
Publikováno v:
Molecules, Vol 18, Iss 12, Pp 15288-15304 (2013)
1-O-Hexadecyl-2-O-methyl-3-O-(2'-amino-2'-deoxy-β-D-glucopyranosyl)-sn-glycerol (1) was previously reported to show potent in vitro antitumor activity on a range of cancer cell lines derived from breast, pancreas and prostate cancer. This compound w
Externí odkaz:
https://doaj.org/article/5588670d18e0418b82a7bf547ee9ed08
Autor:
Pranati Samadder, Makanjuola Ogunsina, Temilolu Idowu, Mark W. Nachtigal, Gilbert Arthur, Frank Schweizer
Publikováno v:
Molecules
Volume 25
Issue 3
Molecules, Vol 25, Iss 3, p 566 (2020)
Volume 25
Issue 3
Molecules, Vol 25, Iss 3, p 566 (2020)
A major impediment to successful cancer treatment is the inability of clinically available drugs to kill drug-resistant cancer cells. We recently identified metabolically stable L-glucosamine-based glycosylated antitumor ether lipids (GAELs) that wer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f4d167923d2ec4832a99137c6bcfad9
Publikováno v:
Chemistry and Physics of Lipids. 194:139-148
Glycosylated antitumor ether lipids (GAELs) kill cancer cells and cancer stem cells via a novel, apoptosis-independent mechanism. In contrast, chlorambucil, a drug in clinical use for the treatment of chronic lymphocytic leukemia reacts with nucleoph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::940fbf9eae54a3db114a82fdfc2751be
https://doi.org/10.1016/j.chemphyslip.2015.07.003
https://doi.org/10.1016/j.chemphyslip.2015.07.003
Publikováno v:
MedChemComm. 7:2100-2110
Glycosylated antitumor ether lipids (GAELs) are a class of amphiphilic antitumor agents that kill cancer cells by a non-apoptotic pathway. Previous studies have shown that 2-amino-2-deoxy-D-gluco-based GAELs such as α-GLN and β-GLN show greatly imp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45cbb13681669462e64cdd151ce78911
https://doi.org/10.1039/c6md00328a
https://doi.org/10.1039/c6md00328a
Publikováno v:
European Journal of Medicinal Chemistry. 78:225-235
Glycosylated antitumor ether lipids (GAELs) 6 and 7 containing a α- or β- d -gluco -configured 2-amino-2-deoxy (2-NH 2 -Glc) sugar moiety linked to a glycerolipid aglycone kill cancer cell lines via a non-apoptotic mechanism that could be exploited
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adb6e5a2099882a0521486f1e6752e33
https://doi.org/10.1016/j.ejmech.2014.03.057
https://doi.org/10.1016/j.ejmech.2014.03.057
Publikováno v:
ChemMedChem. 8:511-520
The potent antitumor activity of 1-O-hexadecyl-2-O-methyl-3-O-(2'-amino-2'-deoxy-β-D-glucopyranosyl)-sn-glycerol (1) was previously shown to arise through an apoptosis-independent pathway. Here, a systematic structure-activity study in which the eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52cd3c3ac6be8f9a9fcfb1fe25e6cc1f
https://doi.org/10.1002/cmdc.201200489
https://doi.org/10.1002/cmdc.201200489
Publikováno v:
ChemMedChem. 5:1045-1052
Analogues of 1-O-hexadecyl-sn-3-glycerophosphonocholine (compounds 1-4) or sn-3-glycerophosphocholine (compound 5) bearing a carbamate or dicarbarnate moiety at the sn-2 position were synthesized and evaluated for their antiproliferative activity aga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e7768c984e9e5227fd99b3b071b61c1
https://doi.org/10.1002/cmdc.201000060
https://doi.org/10.1002/cmdc.201000060
Publikováno v:
Biochemistry and Cell Biology. 87:401-414
Glycosylated antitumor ether lipids (GAELs) have superior anticancer properties relative to the alkyllysophospholipid class, but there have been no studies of the mechanisms of these compounds. The prototype GAEL, 1-O-hexadecyl-2-O-methyl-3-O-(2′-a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::344c1beb2e8b654885bc769d2cc04ca8
https://doi.org/10.1139/o08-147
https://doi.org/10.1139/o08-147