Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Pranathi Vadlamani"'
Autor:
Lauren R. Begg, Adrienne M. Orriols, Markella Zannikou, Chen Yeh, Pranathi Vadlamani, Deepak Kanojia, Rosemary Bolin, Sara F. Dunne, Sanjeev Balakrishnan, Roman Camarda, Diane Roth, Nicolette A. Zielinski-Mozny, Christina Yau, Athanassios Vassilopoulos, Tzu-Hsuan Huang, Kwang-Youn A. Kim, Dai Horiuchi
Publikováno v:
Communications Medicine, Vol 4, Iss 1, Pp 1-17 (2024)
Abstract Background Understanding why some triple-negative breast cancer (TNBC) patients respond poorly to existing therapies while others respond well remains a challenge. This study aims to understand the potential underlying mechanisms distinguish
Externí odkaz:
https://doaj.org/article/bbe12d3b38a147d5bf67e56921985ad3
Publikováno v:
PLoS Biology, Vol 21, Iss 9, p e3002150 (2023)
The ability to alter gene expression programs in response to changes in environmental conditions is central to the ability of an organism to thrive. For most organisms, the nervous system serves as the master regulator in communicating information ab
Externí odkaz:
https://doaj.org/article/7ba2aeb5ebb5431a90fe96a2f56d72a7
Autor:
Reshma Raghava Kurup, Eimile K. Oakes, Pranathi Vadlamani, Obi Nwosu, Pranav Danthi, Heather A. Hundley
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract The RNA binding protein ADAR3 is expressed exclusively in the brain and reported to have elevated expression in tumors of patients suffering from glioblastoma compared to adjacent brain tissue. Yet, other studies have indicated that glioblas
Externí odkaz:
https://doaj.org/article/3a4015789ad5453d80b8ed6500a5fef5
Autor:
Sarah N Deffit, Brian A Yee, Aidan C Manning, Suba Rajendren, Pranathi Vadlamani, Emily C Wheeler, Alain Domissy, Michael C Washburn, Gene W Yeo, Heather A Hundley
Publikováno v:
eLife, Vol 6 (2017)
ADAR proteins alter gene expression both by catalyzing adenosine (A) to inosine (I) RNA editing and binding to regulatory elements in target RNAs. Loss of ADARs affects neuronal function in all animals studied to date. Caenorhabditis elegans lacking
Externí odkaz:
https://doaj.org/article/0be709163d094d89ae3e71f8c13c24d9
Autor:
Roshan L. Shrestha, Vinutha Balachandra, Jee Hun Kim, Austin Rossi, Pranathi Vadlamani, Subhash Chandra Sethi, Laurent Ozbun, Shinjen Lin, Ken Chin-Chien Cheng, Raj Chari, Tatiana S. Karpova, Gianluca Pegoraro, Daniel R. Foltz, Natasha J. Caplen, Munira A. Basrai
Publikováno v:
Journal of Cell Science. 136
Restricting the localization of the evolutionarily conserved centromeric histone H3 variant CENP-A to centromeres prevents chromosomal instability (CIN). The mislocalization of CENP-A to non-centromeric regions contributes to CIN in yeasts, flies and
Publikováno v:
bioRxiv
The ability to alter gene expression programs in response to changes in environmental conditions is central to the ability of an organism to thrive. For most organisms, the nervous system serves as the master regulator in communicating information ab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e8a62c88ae7d22ae649fa4fdd2b5517
https://doi.org/10.1101/2023.05.05.539519
https://doi.org/10.1101/2023.05.05.539519
Autor:
Reshma Raghava Kurup, Eimile K. Oakes, Aidan C. Manning, Priyanka Mukherjee, Pranathi Vadlamani, Heather A. Hundley
Publikováno v:
Journal of Biological Chemistry. 298:102267
Members of the ADAR family of double-stranded RNA-binding proteins regulate one of the most abundant RNA modifications in humans, the deamination of adenosine to inosine. Several transcriptome-wide studies have been carried out to identify RNA target
Autor:
Suba Rajendren, Alfa Dhakal, Jack Townsend, Sarah N. Deffit, Pranathi Vadlamani, Heather A. Hundley
Publikováno v:
Genome Res
Adenosine (A) to inosine (I) RNA editing contributes to transcript diversity and modulates gene expression in a dynamic, cell type–specific manner. During mammalian brain development, editing of specific adenosines increases, whereas the expression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6c92e4350118d11700b1b9e0baed87a
https://europepmc.org/articles/PMC7849389/
https://europepmc.org/articles/PMC7849389/
Autor:
Athanassios Vassilopoulos, Alesia Vialichka, Erica Fleming-Trujillo, Young Ah Goo, Massimo Cristofanilli, Matthew R. Clutter, Pranathi Vadlamani, Marc L. Mendillo, Jessica N. Perrino, Sara Fernandez Dunne, Michelle Velyunskiy, Diane Roth, Adrienne M. Orriols, Rosemary Bolin, Lauren Begg, Byoung-Kyu Cho, Ratika Kunder, Deepak Kanojia, Nicolette A. Zielinski-Mozny, Dai Horiuchi
Publikováno v:
Cell Chem Biol
Triple-negative breast cancer (TNBC) is the breast cancer subtype with the poorest clinical outcome. The PIM family of kinases has emerged as a factor that is both overexpressed in TNBC and associated with poor outcomes. Preclinical data suggest that
Autor:
Michael C. Washburn, Emily C. Wheeler, Sarah N. Deffit, Suba Rajendren, Brian A. Yee, Alain Domissy, Gene W. Yeo, Pranathi Vadlamani, Aidan C. Manning, Heather A. Hundley
Publikováno v:
eLife, Vol 6 (2017)
DNA is the blueprint that tells each cell in an organism how it should operate. It encodes the instructions to make proteins and other molecules. To make a protein, a section of DNA known as a gene is used as a template to make molecules known as mes