Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Pranathi Meda Krishnamurthy"'
Autor:
Minggang Fang, Sara K. Deibler, Pranathi Meda Krishnamurthy, Feng Wang, Paola Rodriguez, Shahid Banday, Ching-Man Virbasius, Miguel Sena-Esteves, Jonathan K. Watts, Michael R. Green
Publikováno v:
Frontiers in Neuroscience, Vol 18 (2024)
Fragile X Syndrome (FXS) is a neurological disorder caused by epigenetic silencing of the FMR1 gene. Reactivation of FMR1 is a potential therapeutic approach for FXS that would correct the root cause of the disease. Here, using a candidate-based shRN
Externí odkaz:
https://doaj.org/article/3a274fd2567945d28c750f6d92ecc94f
Autor:
Hannah M. Pendergraff, Pranathi Meda Krishnamurthy, Alexandre J. Debacker, Michael P. Moazami, Vivek K. Sharma, Liisa Niitsoo, Yong Yu, Yen Nee Tan, Hans Michael Haitchi, Jonathan K. Watts
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 8, Iss , Pp 158-168 (2017)
Two mechanisms dominate the clinical pipeline for oligonucleotide-based gene silencing, namely, the antisense approach that recruits RNase H to cleave target RNA and the RNAi approach that recruits the RISC complex to cleave target RNA. Multiple chem
Externí odkaz:
https://doaj.org/article/983b4e87f8514b7892497bae7b882a6e
Autor:
Shirish Shukla, Uday Sankar Allam, Aarif Ahsan, Guoan Chen, Pranathi Meda Krishnamurthy, Katherine Marsh, Matthew Rumschlag, Sunita Shankar, Christopher Whitehead, Matthew Schipper, Venkatesha Basrur, Daniel R. Southworth, Arul M. Chinnaiyan, Alnawaz Rehemtulla, David G. Beer, Theodore S. Lawrence, Mukesh K. Nyati, Dipankar Ray
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 16, Iss 2, Pp 115-128 (2014)
Attempts to target mutant KRAS have been unsuccessful. Here, we report the identification of Smad ubiquitination regulatory factor 2 (SMURF2) and UBCH5 as a critical E3:E2 complex maintaining KRAS protein stability. Loss of SMURF2 either by small int
Externí odkaz:
https://doaj.org/article/337e778e43f7471c962968f288517f18
Autor:
Dipankar Ray, Shirish Shukla, Uday Sankar Allam, Abigail Helman, Susmita Gurjar Ramanand, Linda Tran, Michael Bassetti, Pranathi Meda Krishnamurthy, Matthew Rumschlag, Michelle Paulsen, Lei Sun, Thomas P Shanley, Mats Ljungman, Mukesh K Nyati, Ming Zhang, Theodore S Lawrence
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e57290 (2013)
The efficacy of radiation therapy for lung cancer is limited by radiation-induced lung toxicity (RILT). Although tumor necrosis factor-alpha (TNF-α) signaling plays a critical role in RILT, the molecular regulators of radiation-induced TNF-α produc
Externí odkaz:
https://doaj.org/article/3235ef109bed43da84dd15564da2bc50
Autor:
Feng Wang, Ezequiel Calvo-Roitberg, Julia M Rembetsy-Brown, Minggang Fang, Jacquelyn Sousa, Zachary J Kartje, Pranathi Meda Krishnamurthy, Jonathan Lee, Michael R Green, Athma A Pai, Jonathan K Watts
Publikováno v:
Nucleic Acids Research. 50:12657-12673
Friedreich’s ataxia is an incurable disease caused by frataxin (FXN) protein deficiency, which is mostly induced by GAA repeat expansion in intron 1 of the FXN gene. Here, we identified antisense oligonucleotides (ASOs), complementary to two region
Autor:
Vignesh N. Hariharan, Minwook Shin, Ching-Wen Chang, Daniel O’Reilly, Annabelle Biscans, Ken Yamada, Zhiru Guo, Mohan Somasundaran, Qi Tang, Kathryn Monopoli, Pranathi Meda Krishnamurthy, Gitali Devi, Nicholas McHugh, David A. Cooper, Dimas Echeverria, John Cruz, Io Long Chan, Ping Liu, Sun-Young Lim, Jill McConnell, Satya Prakash Singh, Samuel Hildebrand, Jacquelyn Sousa, Sarah M. Davis, Zachary Kennedy, Chantal Ferguson, Bruno M. D. C. Godinho, Yann Thillier, Jillian Caiazzi, Socheata Ly, Manish Muhuri, Karen Kelly, Fiachra Humphries, Alyssa Cousineau, Krishna Mohan Parsi, Qi Li, Yang Wang, René Maehr, Guangping Gao, Dmitry Korkin, William M. McDougall, Robert W. Finberg, Katherine A. Fitzgerald, Jennifer P. Wang, Jonathan K. Watts, Anastasia Khvorova
Publikováno v:
Proceedings of the National Academy of Sciences. 120
The continuous evolution of SARS-CoV-2 variants complicates efforts to combat the ongoing pandemic, underscoring the need for a dynamic platform for the rapid development of pan-viral variant therapeutics. Oligonucleotide therapeutics are enhancing t
Publikováno v:
Nucleic Acid Therapeutics
Reliable detection and quantification of antisense oligonucleotides (ASOs) in experimental and clinical specimens are essential to understand the biological function of novel oligonucleotide-based therapeutics. In this study, we describe a method to
Autor:
Minwook Shin, Io Long Chan, Yuming Cao, Alisha M Gruntman, Jonathan Lee, Jacquelyn Sousa, Tomás C Rodríguez, Dimas Echeverria, Gitali Devi, Alexandre J Debacker, Michael P Moazami, Pranathi Meda Krishnamurthy, Julia M Rembetsy-Brown, Karen Kelly, Onur Yukselen, Elisa Donnard, Teagan J Parsons, Anastasia Khvorova, Erik J Sontheimer, René Maehr, Manuel Garber, Jonathan K Watts
Publikováno v:
Nucleic acids research. 50(15)
The lung is a complex organ with various cell types having distinct roles. Antisense oligonucleotides (ASOs) have been studied in the lung, but it has been challenging to determine their effectiveness in each cell type due to the lack of appropriate
Autor:
Craig C. Mello, Yeonsoo Yoon, Hassan Gneid, Jonathan K. Watts, Jaime A. Rivera-Pérez, Ping Xu, Pengpeng Liu, Xiao-Ou Zhang, Judith Gallant, Krishna S. Ghanta, Masahiro Shin, Nathan D. Lawson, Pranathi Meda Krishnamurthy, Ahmet R. Ozturk, Aamir Mir, Erik J. Sontheimer, Zexiang Chen, Alireza Edraki, Gregoriy A Dokshin, Feston Idrizi
Publikováno v:
eLife
eLife, Vol 10 (2021)
eLife, Vol 10 (2021)
Nuclease-directed genome editing is a powerful tool for investigating physiology and has great promise as a therapeutic approach to correct mutations that cause disease. In its most precise form, genome editing can use cellular homology-directed repa
Autor:
Hassan Gneid, Zexiang Chen, Xiao-Ou Zhang, Krishna S. Ghanta, Judith Gallant, Pranathi Meda Krishnamurthy, Gregoriy A Dokshin, Ping Xu, Masahiro Shin, Jonathan K. Watts, Aamir Mir, Erik J. Sontheimer, Pengpeng Liu, Ahmet R. Ozturk, Craig C. Mello, Feston Idrizi, Alireza Edraki, Yeonsoo Yoon, Nathan D. Lawson, Jaime A. Rivera-Pérez
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d121f3c8a2d65cde404482314c798819
https://doi.org/10.7554/elife.72216.sa2
https://doi.org/10.7554/elife.72216.sa2