Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Pranami Bora"'
Autor:
Alessio Paris, Pranami Bora, Silvia Parolo, Drew MacCannell, Michael Monine, Nick van derMunnik, Xiao Tong, Satish Eraly, Zdenek Berger, Danielle Graham, Toby Ferguson, Enrico Domenici, Ivan Nestorov, Luca Marchetti
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 2, Pp 196-206 (2023)
Abstract Phosphorylated neurofilament heavy subunit (pNfH) has been recently identified as a promising biomarker of disease onset and treatment efficacy in spinal muscular atrophy (SMA). This study introduces a quantitative systems pharmacology model
Externí odkaz:
https://doaj.org/article/9c84e240cf754f71aacd8847664a671a
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Alzheimer’s disease is the most common form of dementia. Notwithstanding the huge investments in drug development, only one disease-modifying treatment has been recently approved. Here we present a single-cell-led systems biology pipeline
Externí odkaz:
https://doaj.org/article/782197ecf79140258cdbfbd1725f622f
Autor:
Alessio Paris, Pranami Bora, Silvia Parolo, Michael Monine, Xiao Tong, Satish Eraly, Eric Masson, Toby Ferguson, Alexander McCampbell, Danielle Graham, Enrico Domenici, Ivan Nestorov, Luca Marchetti
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 11, Iss 4, Pp 447-457 (2022)
Abstract Neurofilaments (Nfs) are the major structural component of neurons. Their role as a potential biomarker of several neurodegenerative diseases has been investigated in past years with promising results. However, even under physiological condi
Externí odkaz:
https://doaj.org/article/de1ae59bb53d404daed33a212cd550f8
Autor:
Gianluca Selvaggio, Silvia Parolo, Pranami Bora, Lorena Leonardelli, John Harrold, Khamir Mehta, Dan A. Rock, Luca Marchetti
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Bispecific T-cell engaging therapies harness the immune system to elicit an effective anticancer response. Modulating the immune activation avoiding potential adverse effects such as cytokine release syndrome (CRS) is a critical aspect to realizing t
Externí odkaz:
https://doaj.org/article/270541bf83af4d05aff80063bff4afea
Autor:
Karla Misselbeck, Silvia Parolo, Francesca Lorenzini, Valeria Savoca, Lorena Leonardelli, Pranami Bora, Melissa J. Morine, Maria Caterina Mione, Enrico Domenici, Corrado Priami
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Metabolic syndrome is characterized by complex phenotypes that increases the risk of cardiovascular disease and type 2 diabetes. Here the authors’ integrative network analysis suggests BTK inhibitor ibrutinib to be a promising treatment through its
Externí odkaz:
https://doaj.org/article/f96705c65bfd49bc85730e82b064dab7
Autor:
Silvia Parolo, Danilo Tomasoni, Pranami Bora, Alan Ramponi, Chanchala Kaddi, Karim Azer, Enrico Domenici, Susana Neves-Zaph, Rosario Lombardo
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Lysosomal storage diseases (LSDs) are characterized by the abnormal accumulation of substrates in tissues due to the deficiency of lysosomal proteins. Among the numerous clinical manifestations, chronic inflammation has been consistently reported for
Externí odkaz:
https://doaj.org/article/2a27f1fc531c4c38a37fb3da8ab9dcc7
Autor:
Alessio Paris, Pranami Bora, Silvia Parolo, Drew MacCannell, Michael Monine, Nick van der Munnik, Xiao Tong, Satish Eraly, Zdenek Berger, Danielle Graham, Toby Ferguson, Enrico Domenici, Ivan Nestorov, Luca Marchetti
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology. 12:196-206
Phosphorylated neurofilament heavy subunit (pNfH) has been recently identified as a promising biomarker of disease onset and treatment efficacy in spinal muscular atrophy (SMA). This study introduces a quantitative systems pharmacology model represen
Publikováno v:
Medical Mycology. 60
Poster session 1, September 21, 2022, 12:30 PM - 1:30 PM Objectives Chronic pulmonary aspergillosis is a slow and progressive lung disease that occurs in apparently immune-competent patients. Pulmonary tuberculosis is considered to be a major predisp
Publikováno v:
Scientific reports. 13(1)
Alzheimer’s disease is the most common form of dementia. Notwithstanding the huge investments in drug development, only one disease-modifying treatment has been recently approved. Here we present a single-cell-led systems biology pipeline for the i
Autor:
Corrado Priami, Melissa J. Morine, Valeria Savoca, Karla Misselbeck, Silvia Parolo, Pranami Bora, Maria Caterina Mione, Francesca Lorenzini, Enrico Domenici, Lorena Leonardelli
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications
Nature Communications
Metabolic syndrome is a pathological condition characterized by obesity, hyperglycemia, hypertension, elevated levels of triglycerides and low levels of high-density lipoprotein cholesterol that increase cardiovascular disease risk and type 2 diabete