A living organoid biobank of patients with Crohn's disease reveals molecular subtypes for personalized therapeutics.

Autor: Tindle C; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA; HUMANOID™ Center of Research Excellence (CoRE), University of California, San Diego, La Jolla, CA 92093, USA., Fonseca AG; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA; HUMANOID™ Center of Research Excellence (CoRE), University of California, San Diego, La Jolla, CA 92093, USA., Taheri S; Department of Computer Science and Engineering, Jacobs School of Engineering, University of California, San Diego, La Jolla, CA 92093, USA., Katkar GD; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA., Lee J; Department of Pathology, University of California, San Diego, La Jolla, CA 92093, USA., Maity P; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA; HUMANOID™ Center of Research Excellence (CoRE), University of California, San Diego, La Jolla, CA 92093, USA., Sayed IM; Department of Pathology, University of California, San Diego, La Jolla, CA 92093, USA., Ibeawuchi SR; Department of Pathology, University of California, San Diego, La Jolla, CA 92093, USA., Vidales E; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA; HUMANOID™ Center of Research Excellence (CoRE), University of California, San Diego, La Jolla, CA 92093, USA., Pranadinata RF; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA; HUMANOID™ Center of Research Excellence (CoRE), University of California, San Diego, La Jolla, CA 92093, USA., Fuller M; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA; HUMANOID™ Center of Research Excellence (CoRE), University of California, San Diego, La Jolla, CA 92093, USA., Stec DL; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA; HUMANOID™ Center of Research Excellence (CoRE), University of California, San Diego, La Jolla, CA 92093, USA., Anandachar MS; Department of Pathology, University of California, San Diego, La Jolla, CA 92093, USA., Perry K; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA; HUMANOID™ Center of Research Excellence (CoRE), University of California, San Diego, La Jolla, CA 92093, USA., Le HN; Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA., Ear J; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA., Boland BS; Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address: bboland@health.ucsd.edu., Sandborn WJ; Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address: wsandborn@health.ucsd.edu., Sahoo D; Department of Computer Science and Engineering, Jacobs School of Engineering, University of California, San Diego, La Jolla, CA 92093, USA; Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address: dsahoo@ucsd.edu., Das S; HUMANOID™ Center of Research Excellence (CoRE), University of California, San Diego, La Jolla, CA 92093, USA; Department of Pathology, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address: soumita_das@uml.edu., Ghosh P; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA; HUMANOID™ Center of Research Excellence (CoRE), University of California, San Diego, La Jolla, CA 92093, USA; Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address: prghosh@ucsd.edu.

Publikováno v: Cell reports. Medicine [Cell Rep Med] 2024 Oct 15; Vol. 5 (10), pp. 101748. Date of Electronic Publication: 2024 Sep 26.

Pharmacology of a Potent and Novel Inhibitor of the NOD-Like Receptor Pyrin Domain-Containing Protein 3 (NLRP3) Inflammasome that Attenuates Development of Nonalcoholic Steatohepatitis and Liver Fibrosis.

Autor: Povero D; Jecure Therapeutics, San Diego, California (D.P., M.L., C.M., G.A.-A., R.S., A.M.S., R.F.P., J.A.S., J.M.V., G.B.) and Department of Pediatrics, University of California San Diego (UCSD), La Jolla, California (C.D.J., M.D.M., H.M.H., A.E.F.) povero.davide@mayo.edu., Lazic M; Jecure Therapeutics, San Diego, California (D.P., M.L., C.M., G.A.-A., R.S., A.M.S., R.F.P., J.A.S., J.M.V., G.B.) and Department of Pediatrics, University of California San Diego (UCSD), La Jolla, California (C.D.J., M.D.M., H.M.H., A.E.F.)., McBride C; Jecure Therapeutics, San Diego, California (D.P., M.L., C.M., G.A.-A., R.S., A.M.S., R.F.P., J.A.S., J.M.V., G.B.) and Department of Pediatrics, University of California San Diego (UCSD), La Jolla, California (C.D.J., M.D.M., H.M.H., A.E.F.)., Ambrus-Aikelin G; Jecure Therapeutics, San Diego, California (D.P., M.L., C.M., G.A.-A., R.S., A.M.S., R.F.P., J.A.S., J.M.V., G.B.) and Department of Pediatrics, University of California San Diego (UCSD), La Jolla, California (C.D.J., M.D.M., H.M.H., A.E.F.)., Stansfield R; Jecure Therapeutics, San Diego, California (D.P., M.L., C.M., G.A.-A., R.S., A.M.S., R.F.P., J.A.S., J.M.V., G.B.) and Department of Pediatrics, University of California San Diego (UCSD), La Jolla, California (C.D.J., M.D.M., H.M.H., A.E.F.)., Johnson CD; Jecure Therapeutics, San Diego, California (D.P., M.L., C.M., G.A.-A., R.S., A.M.S., R.F.P., J.A.S., J.M.V., G.B.) and Department of Pediatrics, University of California San Diego (UCSD), La Jolla, California (C.D.J., M.D.M., H.M.H., A.E.F.)., Santini AM; Jecure Therapeutics, San Diego, California (D.P., M.L., C.M., G.A.-A., R.S., A.M.S., R.F.P., J.A.S., J.M.V., G.B.) and Department of Pediatrics, University of California San Diego (UCSD), La Jolla, California (C.D.J., M.D.M., H.M.H., A.E.F.)., Pranadinata RF; Jecure Therapeutics, San Diego, California (D.P., M.L., C.M., G.A.-A., R.S., A.M.S., R.F.P., J.A.S., J.M.V., G.B.) and Department of Pediatrics, University of California San Diego (UCSD), La Jolla, California (C.D.J., M.D.M., H.M.H., A.E.F.)., McGeough MD; Jecure Therapeutics, San Diego, California (D.P., M.L., C.M., G.A.-A., R.S., A.M.S., R.F.P., J.A.S., J.M.V., G.B.) and Department of Pediatrics, University of California San Diego (UCSD), La Jolla, California (C.D.J., M.D.M., H.M.H., A.E.F.)., Stafford JA; Jecure Therapeutics, San Diego, California (D.P., M.L., C.M., G.A.-A., R.S., A.M.S., R.F.P., J.A.S., J.M.V., G.B.) and Department of Pediatrics, University of California San Diego (UCSD), La Jolla, California (C.D.J., M.D.M., H.M.H., A.E.F.)., Hoffman HM; Jecure Therapeutics, San Diego, California (D.P., M.L., C.M., G.A.-A., R.S., A.M.S., R.F.P., J.A.S., J.M.V., G.B.) and Department of Pediatrics, University of California San Diego (UCSD), La Jolla, California (C.D.J., M.D.M., H.M.H., A.E.F.)., Feldstein AE; Jecure Therapeutics, San Diego, California (D.P., M.L., C.M., G.A.-A., R.S., A.M.S., R.F.P., J.A.S., J.M.V., G.B.) and Department of Pediatrics, University of California San Diego (UCSD), La Jolla, California (C.D.J., M.D.M., H.M.H., A.E.F.)., Veal JM; Jecure Therapeutics, San Diego, California (D.P., M.L., C.M., G.A.-A., R.S., A.M.S., R.F.P., J.A.S., J.M.V., G.B.) and Department of Pediatrics, University of California San Diego (UCSD), La Jolla, California (C.D.J., M.D.M., H.M.H., A.E.F.)., Bain G; Jecure Therapeutics, San Diego, California (D.P., M.L., C.M., G.A.-A., R.S., A.M.S., R.F.P., J.A.S., J.M.V., G.B.) and Department of Pediatrics, University of California San Diego (UCSD), La Jolla, California (C.D.J., M.D.M., H.M.H., A.E.F.).

Publikováno v: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2023 Aug; Vol. 386 (2), pp. 242-258. Date of Electronic Publication: 2023 Jun 12.

Artificial intelligence guided discovery of a barrier-protective therapy in inflammatory bowel disease.

Autor: Sahoo D; Department of Pediatrics, University of California San Diego, San Diego, CA, USA. dsahoo@ucsd.edu.; Department of Computer Science and Engineering, Jacob's School of Engineering, University of California San Diego, San Diego, CA, USA. dsahoo@ucsd.edu.; Rebecca and John Moore Comprehensive Cancer Center, University of California San Diego, San Diego, CA, USA. dsahoo@ucsd.edu., Swanson L; Department of Cellular and Molecular Medicine, University of California San Diego, San Diego, CA, USA., Sayed IM; Department of Medical Microbiology and Immunology, Faculty of Medicine, Assiut University, Assiu, Egypt.; Department of Pathology, University of California San Diego, San Diego, CA, USA., Katkar GD; Department of Cellular and Molecular Medicine, University of California San Diego, San Diego, CA, USA., Ibeawuchi SR; Department of Pathology, University of California San Diego, San Diego, CA, USA., Mittal Y; Department of Medicine, University of California San Diego, San Diego, CA, USA., Pranadinata RF; Department of Cellular and Molecular Medicine, University of California San Diego, San Diego, CA, USA., Tindle C; Department of Cellular and Molecular Medicine, University of California San Diego, San Diego, CA, USA., Fuller M; Department of Cellular and Molecular Medicine, University of California San Diego, San Diego, CA, USA., Stec DL; Department of Cellular and Molecular Medicine, University of California San Diego, San Diego, CA, USA., Chang JT; Department of Medicine, University of California San Diego, San Diego, CA, USA., Sandborn WJ; Department of Medicine, University of California San Diego, San Diego, CA, USA., Das S; Department of Pathology, University of California San Diego, San Diego, CA, USA. sodas@ucsd.edu., Ghosh P; Rebecca and John Moore Comprehensive Cancer Center, University of California San Diego, San Diego, CA, USA. prghosh@ucsd.edu.; Department of Cellular and Molecular Medicine, University of California San Diego, San Diego, CA, USA. prghosh@ucsd.edu.; Department of Medicine, University of California San Diego, San Diego, CA, USA. prghosh@ucsd.edu.; Veterans Affairs Medical Center, La Jolla, CA, USA. prghosh@ucsd.edu.

Publikováno v: Nature communications [Nat Commun] 2021 Jul 12; Vol. 12 (1), pp. 4246. Date of Electronic Publication: 2021 Jul 12.

TLR4 signaling and macrophage inflammatory responses are dampened by GIV/Girdin.

Autor: Swanson L; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA 92093., Katkar GD; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA 92093., Tam J; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA 92093., Pranadinata RF; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA 92093., Chareddy Y; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA 92093., Coates J; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA 92093., Anandachar MS; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA 92093., Castillo V; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA 92093., Olson J; Department of Pediatrics, University of California San Diego, La Jolla, CA 92093., Nizet V; Department of Pediatrics, University of California San Diego, La Jolla, CA 92093.; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA 92093., Kufareva I; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA 92093., Das S; Department of Pathology, University of California San Diego, La Jolla, CA 92093., Ghosh P; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA 92093; prghosh@ucsd.edu.; Department of Medicine, University of California San Diego, La Jolla, CA 92093.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Oct 27; Vol. 117 (43), pp. 26895-26906. Date of Electronic Publication: 2020 Oct 14.