Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Pranab Maiti"'
Autor:
Bharat Lagu, Michael Webb, Pranab Maiti, Arthur F. Kluge, Jyoti Malhotra, P. Akhila Srinivas, James E. Thompson, Ashley Mallat, Mahaboobi Jaleel
Publikováno v:
Bioorganicmedicinal chemistry letters. 28(15)
Mitophagy is one of the processes that cells use to maintain overall health. An E3 ligase, parkin, ubiquitinates mitochondrial proteins prior to their degradation by autophagasomes. USP30 is an enzyme that de-ubiquitinates mitochondrial proteins; the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b97527aa8a23c2e86ce12f953f1aa4a
https://pubmed.ncbi.nlm.nih.gov/29935771
https://pubmed.ncbi.nlm.nih.gov/29935771
Autor:
Steven D. Kahl, Kelly L. Wilbur, Warshawsky Alan M, Jayana Pankaj Lineswala, Siddaramaiah Cr, Pranab Maiti, Sweetana Stephanie Ann, Diseroad Benjamin Alan, Lisa A. Adams, Yanyun Chen, Richard W. Zink, Anne Reifel Miller, Grace L. Neathery, Anjana Patel Lewis, Over Cabrera, Alison N. Campbell, Guemalli R. Cardona, Nathan Yumibe, Keyue Chen, Keith A. Otto, Cecilia Bouaichi, Xiaosu Ma, Chafiq Hamdouchi, Amy C. DeBaillie, Chahrzad Montrose-Rafizadeh
Publikováno v:
Journal of medicinal chemistry. 61(3)
As a part of our program to identify potent GPR40 agonists capable of being dosed orally once daily in humans, we incorporated fused heterocycles into our recently disclosed spiropiperidine and tetrahydroquinoline acid derivatives 1, 2, and 3 with th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba33126a14f55ea8f6b1d4d12011e1a1
https://pubmed.ncbi.nlm.nih.gov/29236497
https://pubmed.ncbi.nlm.nih.gov/29236497
Autor:
Anne Reifel Miller, Marialuisa C. Marcelo, Qi Chen, Ruth Belin, Pranab Maiti, Joseph V. Haas, Jared L. Piper, Ellen A. Cannady, Steven D. Kahl, Anjana Patel Lewis, Guemalli R. Cardona, Jason T. Johnson, D. Scott Coffey, Dawn A. Brooks, James Ficorilli, Xiaosu Ma, Sweetana Stephanie Ann, Chafiq Hamdouchi, Yanyun Chen, Edward J. Pratt, Keyue Chen, Richard W. Zink, Kelly L. Wilbur, Keith A. Otto, Mark A. Deeg, Nathan Yumibe, Jayana Pankaj Lineswala, Thomas E Eessalu, Chahrzad Montrose-Rafizadeh
Publikováno v:
Journal of medicinal chemistry. 59(24)
The G protein-coupled receptor 40 (GPR40) also known as free fatty acid receptor 1 (FFAR1) is highly expressed in pancreatic, islet β-cells and responds to endogenous fatty acids, resulting in amplification of insulin secretion only in the presence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e874164fca96fc6edd42ba967fc574b
https://pubmed.ncbi.nlm.nih.gov/27749056
https://pubmed.ncbi.nlm.nih.gov/27749056
Autor:
Pranab Maiti, Atul Tiwari
Publikováno v:
Drug Discovery Today. 14:523-530
Over the past decade, new roles for bile acids in paracrine and endocrine regulation of cholesterol homeostasis, lipid and carbohydrate metabolism and immunomodulatory functions have been discovered. Most of the early discoveries focused on the genom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::274d293a387e1a7e41eacb27fd68f6ea
https://doi.org/10.1016/j.drudis.2009.02.005
https://doi.org/10.1016/j.drudis.2009.02.005
Publikováno v:
Biochemistry. 45:852-860
The accumulation of the lipofuscin fluorophores in retinal pigment epithelial (RPE) cells leads to the blinding degeneration characteristic of Stargardt disease and related forms of macular degeneration. RPE lipofuscin, including the fluorophore A2E,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::306e67d265156cbffb5714515c0b1c89
https://doi.org/10.1021/bi0518545
https://doi.org/10.1021/bi0518545
Publikováno v:
Biochemistry. 44:14463-14469
Membrane-bound RPE65 (mRPE65) is a binding protein for all-trans-retinyl esters, which are the substrates for the isomerization reaction that completes the visual cycle. RPE65 is essential for rhodopsin regeneration and, hence, for vision. As RPE65 a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cee1b1841ec482112e9c0e24e0c70a2d
https://doi.org/10.1021/bi0510779
https://doi.org/10.1021/bi0510779
Publikováno v:
Cell. 117(6):761-771
RPE65 is essential for the biosynthesis of 11-cis-retinal, the chromophore of rhodopsin. Here, we show that the membrane-associated form (mRPE65) is triply palmitoylated and is a chaperone for all-trans-retinyl esters, allowing their entry into the v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24f0a7d552b8648519d89c3260a30242
RPE65 Operates in the Vertebrate Visual Cycle by Stereospecifically Binding All-trans-Retinyl Esters
Publikováno v:
Biochemistry. 42:11824-11830
RPE65 is a major protein of unknown function found associated with the retinyl pigment epithelial (RPE) membranes [Hamel, C. P., Tsilou, E., Pfeffer, B. A., Hooks, J. J., Detrick, B., and Redmond, T. M. (1993) J. Biol. Chem. 268, 15751-15757; Bavik,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9726124297854c1cb4697cbd85c36120
https://doi.org/10.1021/bi035227w
https://doi.org/10.1021/bi035227w
Publikováno v:
Organicbiomolecular chemistry. 1(22)
R-5-Methylcyclohex-2-enone 1 reacts successively with the phenyldimethylsilylzincate reagent and acetaldehyde to give with regiocontrol the aldols 7, dehydration of which creates the E-exocyclic double bond of the alpha,beta-unsaturated ketone 2. Con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a2ea49deb0f4c3f5f244393cc25d3d5
https://pubmed.ncbi.nlm.nih.gov/14664388
https://pubmed.ncbi.nlm.nih.gov/14664388