Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Pramod S Terse"'
Autor:
Gensheng Wang, Christopher H Evans, Janet M Benson, Julie A Hutt, JeanClare Seagrave, Julie A Wilder, Joshua C Grieger, R Jude Samulski, Pramod S Terse
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 3, Iss C (2016)
Interleukin-1 (IL-1) plays an important role in the pathophysiology of osteoarthritis (OA), and gene transfer of IL-1 receptor antagonist (IL-1Ra) holds promise for OA treatment. A preclinical safety and biodistribution study evaluated a self-complem
Externí odkaz:
https://doaj.org/article/6c9baaef7b4e465f9ba978ec9d3129c7
Autor:
Jessica M. Faupel-Badger, Amanda L. Vogel, Shadab F. Hussain, Christopher P. Austin, Matthew D. Hall, Elizabeth Ness, Philip Sanderson, Pramod S. Terse, Xin Xu, Krishna Balakrishnan, Samarjit Patnaik, Juan J. Marugan, Udo Rudloff, Marc Ferrer
Publikováno v:
Journal of Clinical and Translational Science, Vol 6 (2022)
There are numerous examples of translational science innovations addressing challenges in the translational process, accelerating progress along the translational spectrum, and generating solutions relevant to a wide range of human health needs. Exam
Externí odkaz:
https://doaj.org/article/d04c5654f35f49988876957604e51d81
Autor:
Elizabeth A. Ottinger, Anne Pariser, Philip J. Brooks, Asaf Alimardanov, Christopher P. Austin, Richa Madan Lomash, Eric Esposito, Pramod S. Terse, Carsten G. Bönnemann, Xin Xu, Deanna Portero, Randy J. Chandler, Janelle Geist Hauserman, Charles P. Venditti, Donald C. Lo
Publikováno v:
Human Gene Therapy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5baa4221778a870fb9ecaeeecfde7506
https://doi.org/10.1089/hum.2020.259
https://doi.org/10.1089/hum.2020.259
Autor:
William B. J. Cafferty, Xingxing Wang, Stephen M. Strittmatter, Tianna Zhou, George D. Maynard, Jeffery D. Kocsis, Pramod S Terse
Publikováno v:
Brain
After CNS trauma such as spinal cord injury, the ability of surviving neural elements to sprout axons, reorganize neural networks and support recovery of function is severely restricted, contributing to chronic neurological deficits. Among limitation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2122ea96e4494f221d54a29008e268f
https://doi.org/10.1093/brain/awaa116
https://doi.org/10.1093/brain/awaa116
Publikováno v:
Regul Toxicol Pharmacol
Pancreatic cancer is a leading cause of cancer-related deaths in the U.S. Ninety percent of patients with stage IV pancreatic cancer die within one year of diagnosis due to complications of metastasis. A metastatic potential of cancer cells has been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05745b2ab9fc91de6e0c1b3c205376ad
https://pubmed.ncbi.nlm.nih.gov/32619635
https://pubmed.ncbi.nlm.nih.gov/32619635
Autor:
Betty S. Pace, Hanny Al-Samkari, Sujit Sheth, Abdullah Kutlar, Xin Xu, Pramod S. Terse, Seyed Mehdi Nouraie, Susan P. Perrine, Aidan D Faller, Kevin H.M. Kuo, Sharie J. Haugabook, Sylvia Titi Singer, Arthur J. Sytkowski, Franciscus A. Kuypers, Haksong Jin, Gershwin Blyden, Lanetta Bronté-Hall, Asaf Alimardanov
Publikováno v:
Blood. 138:4159-4159
Increased expression of fetal globin (HBG) has been shown to reduce clinical severity of beta-globin disorders and increase survival in sickle cell disease (SCD), through improved globin chain balance in beta thalassemia and reduced HbS polymerizatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fcafe7d2927303f1f9aca7f816cc3a5b
https://doi.org/10.1182/blood-2021-148909
https://doi.org/10.1182/blood-2021-148909
Autor:
Jeffrey J. Wallery, Pramod S. Terse, Joseph Novak, John C. McKew, Seth Gibbs, Vijay P. Kale, Minh-Ha T Do
Publikováno v:
Toxicol Appl Pharmacol
Cyclocreatine (LUM-001) was evaluated for chronic toxicity (23 weeks) in beagle dogs to support clinical development in patients with creatine transporter deficiency (CTD) disorder. Deionized water (vehicle control) or cyclocreatine was administered
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fce2456b0a9cb6b622453ad36a4eceb1
https://doi.org/10.1016/j.taap.2021.115680
https://doi.org/10.1016/j.taap.2021.115680
Publikováno v:
Regulatory Toxicology and Pharmacology. 123:104939
In standard general toxicology studies in two species to support clinical development, cyclocreatine, a creatine analog for the treatment of creatine transporter deficiency, caused deaths, convulsions, and/or multi-organ pathology. The potential tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b578f1506571bc3f1e05f01ff09f9a56
https://doi.org/10.1016/j.yrtph.2021.104939
https://doi.org/10.1016/j.yrtph.2021.104939
Autor:
Carla Ciccone, Nuria Carrillo, Barry R. Goldspiel, John C. McKew, Nora Yang, May Christine V. Malicdan, Amy Wang, Frank Celeste, Lea Latham, Pramod S. Terse, James Cradock, Marjan Huizing, Xin Xu, William A. Gahl, Selwyn Yorke
Publikováno v:
Molecular Genetics and Metabolism. 122:126-134
GNE myopathy is a rare, autosomal recessive, inborn error of sialic acid metabolism, caused by mutations in GNE, the gene encoding UDP-N-acetyl-glucosamine-2-epimerase/N-acetylmannosamine kinase. The disease manifests as an adult-onset myopathy chara
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b44382db5a79dafd4e6d16663e67536a
https://doi.org/10.1016/j.ymgme.2017.04.010
https://doi.org/10.1016/j.ymgme.2017.04.010
Publikováno v:
Toxicology Mechanisms and Methods. 27:518-527
DON (6-diazo-5-oxo-l-norleucine), a glutamine antagonist, was demonstrated to exhibit analgesic, antibacterial, antiviral and anticancer properties. The study was performed to characterize its in vitro and in vivo genetic toxicity potential. DON was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::825b7a3d426c6b32704aacd2a9db24a9
https://doi.org/10.1080/15376516.2017.1333552
https://doi.org/10.1080/15376516.2017.1333552