Výsledky vyhledávání - "Pramod Kumar Ek"

Akademický článek

Hyaluronic Acid Nanoparticles as Nanomedicine for Treatment of Inflammatory Diseases

Autor: N.Vijayakameswara Rao, Jun Gi Rho, Wooram Um, Pramod Kumar EK, Van Quy Nguyen, Byeong Hoon Oh, Wook Kim, Jae Hyung Park

Publikováno v: Pharmaceutics, Vol 12, Iss 10, p 931 (2020)

Owing to their unique biological functions, hyaluronic acid (HA) and its derivatives have been explored extensively for biomedical applications such as tissue engineering, drug delivery, and molecular imaging. In particular, self-assembled HA nanopar

Externí odkaz: https://doaj.org/article/9e03fc19f78941fa8242985ca8e80e0d

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Shear stress regulated uptake of liposome-decorated microgels coated with a poly(dopamine) shell

Autor: Leticia Hosta-Rigau, Pramod Kumar Ek, Maria Godoy-Gallardo, Maria Jose York-Duran

Publikováno v: York-Durán, M J, Ek, P K, Gallardo, M G & Hosta-Rigau, L 2018, ' Shear stress regulated uptake of liposome-decorated microgels coated with a poly(dopamine) shell ', Colloids and Surfaces B: Biointerfaces, vol. 171, pp. 427-436 . https://doi.org/10.1016/j.colsurfb.2018.07.031

Advanced multicompartment drug delivery platforms ensure the co-localization of several drugs within the same carrier, thus making it possible to achieve a more effective and safe therapeutic outcome. Herein, we report a novel multicompartment archit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::287a3afab1fb149809eae00c223e0572
https://doi.org/10.1016/j.colsurfb.2018.07.031

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PET imaging with copper-64 as a tool for real-time in vivo investigations of the necessity for cross-linking of polymeric micelles in nanomedicine

Autor: Palle Rasmussen, Andreas Tue Ingemann Jensen, Pramod Kumar Ek, Tina Binderup, Constance E Grandjean, Thomas Lars Andresen, Andreas Kjaer

Publikováno v: Jensen, A I, Binderup, T, Ek, P K, Grandjean, C E, Rasmussen, P H, Kjaer, A & Andresen, T L 2017, ' PET imaging with copper-64 as a tool for real-time in vivo investigations of the necessity for cross-linking of polymeric micelles in nanomedicine ', Journal of Labelled Compounds and Radiopharmaceuticals, vol. 60, no. 8, pp. 366-374 . https://doi.org/10.1002/jlcr.3510

Polymeric micelles in nanomedicine are often cross-linked to prevent disintegration in vivo. This typically requires clinically problematic chemicals or laborious procedures. In addition, cross-linking may interfere with advanced release strategies.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45e36bed81f774910a4365a1ec522d91
https://doi.org/10.1002/jlcr.3510

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Convenient one-step synthesis of 5-carboxy-seminaphthofluoresceins

Autor: Erling Thyrhaug, Thomas Lars Andresen, Mads Hartvig Clausen, Pramod Kumar Ek, Pernille Harris, Peter Hammershøj

Publikováno v: Hammershøj, P, Thyhaug, E, Harris, P, Ek, P K, Andresen, T L & Clausen, M H 2017, ' Convenient one-step synthesis of 5-carboxy-seminaphthofluoresceins ', Tetrahedron Letters, vol. 58, no. 16, pp. 1611-1615 . https://doi.org/10.1016/j.tetlet.2017.03.028

The one-step synthesis and characterization of a series of regioisomerically pure 5-carboxy-seminaphthofluoresceins (5-carboxy-SNAFLs) is reported. The optical properties were determined in aqueous buffer at around biological pH, and highly pH sensit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa6fa5d70a82027f643d6420a2fa77d9
https://doi.org/10.1016/j.tetlet.2017.03.028

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Positron Emission Tomography Based Analysis of Long-Circulating Cross-Linked Triblock Polymeric Micelles in a U87MG Mouse Xenograft Model and Comparison of DOTA and CB-TE2A as Chelators of Copper-64

Autor: Palle Rasmussen, Tina Binderup, Andreas Tue Ingemann Jensen, Thomas Lars Andresen, Pramod Kumar Ek, Andreas Kjaer

Publikováno v: Biomacromolecules. 15:1625-1633

Copolymers of ABC-type (PEG-PHEMA-PCMA) architecture were prepared by atom transfer radical polymerization and formulated as micelles with functionalizable primary alcohols in the shell-region (PHEMA-block) to which the metal-ion chelators DOTA or CB

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::726c5063b9561f58ce46194ed38cdad0
https://doi.org/10.1021/bm401871w

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Differential toxicological response to positively and negatively charged nanoparticles in the rat brain

Autor: Steen Larsen, Kristina Bram Knudsen, Helle Northeved, Henrik Rye Lam, Jens Lykkesfeldt, Pramod Kumar Ek, Anders Permin, Thomas Lars Andresen, Karen Malene Wegener

Publikováno v: Nanotoxicology. :1-33

We investigated the potential for systemic and local toxicity after administration of empty nanosized anionic and cationic PEGylated-micelles and non-PEGylated liposomes, without a ligand attached, intended for use in drug-delivery systems. The parti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ff379fab47e976fbd0a04ce77dd7254
https://doi.org/10.3109/17435390.2013.829589

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Intracellular Microreactors as Artificial Organelles to Conduct Multiple Enzymatic Reactions Simultaneously

Autor: Pramod Kumar Ek, Leticia Hosta-Rigau, Maria Godoy-Gallardo, Michelle M. T. Jansman, Cédric Labay

Publikováno v: Advanced healthcare materials. 6(4)

The creation of artificial organelles is a new paradigm in medical therapy that aims to substitute for missing cellular function by replenishing a specific cellular task. Artificial organelles tackle the challenge of mimicking metabolism, which is th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42b57bea874bc083df4dd5e8c7728959
https://pubmed.ncbi.nlm.nih.gov/28004530

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In vivo toxicity of cationic micelles and liposomes

Autor: Martin Roursgaard, Torben Gjetting, Anders Permin, Helle Northeved, Kristina Bram Knudsen, Steen Larsen, Pramod Kumar Ek, Thomas Lars Andresen, Steffen Loft, Jens Lykkesfeldt, Peter Møller, Kim Jantzen, Karen Malene Wegener

Publikováno v: Knudsen, K B, Northeved, H, Ek, P K, Permin, A, Gjetting, T, Andresen, T L, Larsen, S, Wegener, K M, Lykkesfeldt, J, Jantzen, K, Loft, S, Møller, P & Roursgaard, M 2015, ' In vivo toxicity of cationic micelles and liposomes ', Nanomedicine: Nanotechnology, Biology and Medicine, vol. 11, no. 2, pp. 467-477 . https://doi.org/10.1016/j.nano.2014.08.004

This study investigated toxicity of nanocarriers comprised of cationic polymer and lipid components often used in gene and drug delivery, formulated as cationic micelles and liposomes. Rats were injected intravenously with 10, 25 or 100mg/kg and sacr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b662b00ddf1232e622bdab8eb9e82969
https://pubmed.ncbi.nlm.nih.gov/25168934

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Interaction between drug delivery vehicles and cells under the effect of shear stress

Autor: Maria Godoy-Gallardo, B. M. Wohl, Michelle M. T. Jansman, Pramod Kumar Ek, Leticia Hosta-Rigau

Publikováno v: Biomicrofluidics. 9:052605

Over the last decades, researchers have developed an ever greater and more ingenious variety of drug delivery vehicles (DDVs). This has made it possible to encapsulate a wide selection of therapeutic agents, ranging from proteins, enzymes, and peptid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afb3efd88c63e6d46c933a81377db5f2
https://doi.org/10.1063/1.4923324

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