Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Pramod K. Kushawaha"'
Publikováno v:
Microbial pathogenesis. 166
Leishmania donovani pathogenicity is closely linked to its ability to live and replicate in the hostile environment of macrophages. All protozoan parasites, including Leishmania, are unable to synthesize purines de novo, and nucleoside diphosphate ki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d093cbac7ee7867ae82227f38018b17a
https://pubmed.ncbi.nlm.nih.gov/35219843
https://pubmed.ncbi.nlm.nih.gov/35219843
Autor:
Pramod K Kushawaha, Reema Gupta, Chandra Dev Pati Tripathi, Prashant Khare, Anil Kumar Jaiswal, Shyam Sundar, Anuradha Dube
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e45766 (2012)
Visceral leishmaniasis (VL) is one of the most important parasitic diseases with approximately 350 million people at risk. Due to the non availability of an ideal drug, development of a safe, effective, and affordable vaccine could be a solution for
Externí odkaz:
https://doaj.org/article/6f425a77b9b44a21983cfdfd7bb199ef
Autor:
Rajender S. Sangwan, Anuradha Dube, Chitra Mandal, Pramod K. Kushawaha, Shailja Misra-Bhattacharya, Chandra Dev Pati Tripathi
Publikováno v:
Phytomedicine. 24:87-95
Background Withania somnifera (L.) Dunal (Solanaceae), commonly known as Ashwagandha, is one of the most important medicinal plant in the traditional Indian medical systems. Pharmacological studies have established that root extracts of W. somnifera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::049132f4312430375e1fba4c8b03ddaf
https://doi.org/10.1016/j.phymed.2016.11.012
https://doi.org/10.1016/j.phymed.2016.11.012
Autor:
Soumen Basak, Shailly Tomar, Rakesh Pandey, Naseem Ahmed Khan, Yashika Ratra, Guruprasad R. Medigeshi, Sachendra S. Bais, Abhyudai Singh, Pramod K. Kushawaha
Chandipura virus (CHPV), a cytoplasmic RNA virus, has been implicated in several outbreaks of acute encephalitis in India. Despite the relevance of CHPV to human health, how the virus interacts with the host signaling machinery remains obscure. In re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fecd1452b99cea0ef9db8fd47df99c14
https://europepmc.org/articles/PMC6600208/
https://europepmc.org/articles/PMC6600208/
SummaryIn response to infection by RNA viruses, mammalian cells typically activate RelA-containing NF-κB heterodimers, which induce genes encoding interferon-β and other antiviral mediators. Therefore, RelA is commonly thought to function as an ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a441fa3ca4171a2ceccf790257a9a93d
https://doi.org/10.1101/509893
https://doi.org/10.1101/509893
Autor:
Sanchita Das, Reema Gupta, Anuradha Dube, Shyam Sundar, Chandra Dev Pati Tripathi, Rati Tandon, Keerti Rawat, Pramod K. Kushawaha, Rajendra K. Baharia, Narendra Kumar Yadav, Anil K. Jaiswal, Prashant Khare, Sumit Joshi, Amogh A. Sahasrabuddhe
Publikováno v:
Frontiers in Microbiology, Vol 7 (2016)
Frontiers in Microbiology
Frontiers in Microbiology
Our prior studies demonstrated that cellular response of T helper 1 (Th1) type was generated by a soluble antigenic fraction (ranging from 89.9 to 97.1 kDa) of Leishmania donovani promastigote, in treated Leishmania patients as well as hamsters and s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7dc3ed5686b3de82c1a0f23a2e0f6e9
https://doi.org/10.3389/fmicb.2016.00312
https://doi.org/10.3389/fmicb.2016.00312
Publikováno v:
The Journal of Immunology. 187:6417-6427
In visceral leishmaniasis, Th1 types of immune responses correlate with recovery from and resistance to disease, and resolution of infection results in lifelong immunity against the disease. Leishmanial Ags that elicit proliferative and cytokine resp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f55a8af2ae1e80051ea75aaa606a2091
https://doi.org/10.4049/jimmunol.1102081
https://doi.org/10.4049/jimmunol.1102081
Autor:
Mukesh Samant, Anuradha Dube, Reema Gupta, Anil K. Jaiswal, Rajendra K. Baharia, Pramod K. Kushawaha
Publikováno v:
Journal of Antimicrobial Chemotherapy. 67:440-443
Objectives Miltefosine, an orally effective antileishmanial drug, works directly on the parasite by impairing membrane synthesis and subsequent apoptosis of the parasite and has also been reported to have macrophage-activating functions that aid para
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f665f3c61cba001813eecdab8fe8f383
https://doi.org/10.1093/jac/dkr485
https://doi.org/10.1093/jac/dkr485
Autor:
Pramod K. Kushawaha, Pragya Misra, Amogh A. Sahasrabuddhe, Mukesh Samant, Prashant Khare, Shraddha Kumari, Reema Gupta, Anuradha Dube
Publikováno v:
The Journal of Immunology. 183:470-479
Leishmania produce several types of mucin-like glycoproteins called proteophosphoglycans (PPGs) which exist as secretory as well as surface-bound forms in both promastigotes and amastigotes. The structure and function of PPGs have been reported to be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b28397f95a9bc027ee4582bcd18df20
https://doi.org/10.4049/jimmunol.0900265
https://doi.org/10.4049/jimmunol.0900265
Autor:
Hemanta K. Majumder, Tanvir Khaliq, Souvik Sengupta, Pramod K. Kushawaha, Tadigoppula Narender, Pragya Misra, Awanish Kumar, Anuradha Dube, Shraddha Kumari, Mukesh Samant, Anshuman Dixit, Anil K. Saxena
Publikováno v:
Journal of Antimicrobial Chemotherapy. 62:998-1002
Objectives: The aim of this study was to resolve the putative pathway responsible for death induced by peganine hydrochloride dihydrate isolated from Peganum harmala seeds at cellular, structural and molecular level in Leishmania donovani, a causativ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c98d74c7f78d7d223ee3d74583d18e24
https://doi.org/10.1093/jac/dkn319
https://doi.org/10.1093/jac/dkn319