Výsledky vyhledávání - "Pramit Chowdhury"

Akademický článek

Artemisinin-resistant Plasmodium falciparum Kelch13 mutant proteins display reduced heme-binding affinity and decreased artemisinin activation

Autor: Abdur Rahman, Sabahat Tamseel, Smritikana Dutta, Nawaal Khan, Mohammad Faaiz, Harshita Rastogi, Jyoti Rani Nath, Kasturi Haldar, Pramit Chowdhury, Ashish, Souvik Bhattacharjee

Publikováno v: Communications Biology, Vol 7, Iss 1, Pp 1-23 (2024)

Abstract The potency of frontline antimalarial drug artemisinin (ART) derivatives is triggered by heme-induced cleavage of the endoperoxide bond to form reactive heme-ART alkoxy radicals and covalent heme-ART adducts, which are highly toxic to the pa

Externí odkaz: https://doaj.org/article/7ae26975befc4a84b88c8d9c651d521e

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Toward the molecular flashlight: preparation, properties, and photophysics of a hypericin-luciferin tethered molecule

Autor: Jin, Wen, Pramit, Chowdhury, Nick J, Wills, Yvonne, Wannemuehler, Jaehun, Park, Sarathy, Kesavan, S, Carpenter, G A, Kraus, J W, Petrich

Publikováno v: Photochemistry and photobiology. 76(2)

The synthesis of a molecule containing hypericin and luciferin moieties joined by a tether is reported. The light-induced (in vitro) antiviral activity as well as the photophysical properties of this new compound are measured and compared with those

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::33ddd5e33bcc6cba0bc51bd1f0eab709
https://pubmed.ncbi.nlm.nih.gov/12194210

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