The Mycobacterium tuberculosis methyltransferase Rv2067c manipulates host epigenetic programming to promote its own survival

Autor: Prakruti R. Singh, Venkatareddy Dadireddy, Shubha Udupa, Shashwath Malli Kalladi, Somnath Shee, Sanjeev Khosla, Raju S. Rajmani, Amit Singh, Suryanarayanarao Ramakumar, Valakunja Nagaraja

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)

Abstract Mycobacterium tuberculosis has evolved several mechanisms to counter host defense arsenals for its proliferation. Here we report that M. tuberculosis employs a multi-pronged approach to modify host epigenetic machinery for its survival. It s

Externí odkaz: https://doaj.org/article/a35a85850b474c0099f01869a8023291

Challenges in elucidating bacteria-host epigenetic dynamics

Autor: Prakruti R Singh, Valakunja Nagaraja

Publikováno v: Epigenomics. 14(2)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a1ffdb5bb86b361791701504c21d8e5
https://pubmed.ncbi.nlm.nih.gov/34676777

Rv0802c is an acyltransferase that succinylates and acetylates

Autor: Chinmay, Anand, Meghna, Santoshi, Prakruti R, Singh, Valakunja, Nagaraja

Publikováno v: Microbiology (Reading, England). 167(7)

Among the nucleoid-associated proteins (NAPs), HU is the most conserved in eubacteria, engaged in overall chromosome organization and regulation of gene expression. Unlike other bacteria, HU from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bba1674ef545fd8fda06acc4205da157
https://pubmed.ncbi.nlm.nih.gov/34224344

DNA flowerstructure co-localizes with human pathogens in infected macrophages

Autor: Simon Pagaard Nielsen, Josephine Geertsen Keller, Pia Jensen, Bárbara Domínguez-Asenjo, Rafael Balaña-Fouce, Rosa M. Reguera, Oskar Franch, Yi-Ping Ho, Birgitta R. Knudsen, Lene N. Nejsum, Valakunja Nagaraja, Prakruti R Singh, Camino Gutiérrez-Corbo, Thomas Boesen, Rajiv Kumar Jha

Publikováno v: Franch, O, Gutiérrez-Corbo, C, Domínguez-Asenjo, B, Boesen, T, Jensen, P B, Nejsum, L N, Keller, J G, Nielsen, S P, Singh, P R, Jha, R K, Nagaraja, V, Balaña-Fouce, R, Ho, Y-P, Reguera, R M & Knudsen, B R 2020, ' DNA flowerstructure co-localizes with human pathogens in infected macrophages ', Nucleic Acids Research, vol. 48, no. 11, pp. 6081-6091 . https://doi.org/10.1093/nar/gkaa341
Nucleic Acids Research

Herein, we characterize the cellular uptake of a DNA structure generated by rolling circle DNA amplification. The structure, termed nanoflower, was fluorescently labeled by incorporation of ATTO488-dUTP allowing the intracellular localization to be f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab50a24b695c53b4fe97bad0e3297700
https://pure.au.dk/portal/da/publications/dna-flowerstructure-colocalizes-with-human-pathogens-in-infected-macrophages(d2bd790f-e247-4056-9f4c-9c1cd4b9eef4).html

Genome-wide non-CpG methylation of the host genome during M. tuberculosis infection

Autor: Sharmistha Banerjee, Sandeep Upadhyay, Vinay Kumar Nandicoori, Prakruti R. Singh, Rakesh Ganji, Divya Tej Sowpati, Garima Sharma, Mehak Zahoor Khan, Sanjeev Khosla

Publikováno v: Scientific Reports

A mammalian cell utilizes DNA methylation to modulate gene expression in response to environmental changes during development and differentiation. Aberrant DNA methylation changes as a correlate to diseased states like cancer, neurodegenerative condi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21f12698376f2673748e7b994a5a8ce4
https://doi.org/10.1038/srep25006