Výsledky vyhledávání - "Prakash Raman"

Multi-drug resistance, integron and transposon-mediated gene transfer in heterotrophic bacteria from Penaeus vannamei and its culture environment

Autor: Ranjit Kumar Nadella, Satyen Kumar Panda, Madhusudana Rao Badireddy, Pani Prasad Kurcheti, Ram Prakash Raman, Mukteswar Prasad Mothadaka

Publikováno v: Environmental Science and Pollution Research. 29:37527-37542

Multi-drug resistance (MDR) in bacteria is regarded as an emerging pollutant in different food production avenues including aquaculture. One hundred and sixty out of 2304 bacterial isolates from shrimp farm samples (n = 192) of Andhra Pradesh, India,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bab4ffbf8e18cde7aaab28238b3ce81f
https://doi.org/10.1007/s11356-021-18163-1

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A Diacylglycerol Transferase 1 Inhibitor Is a Potent Hepatitis C Antiviral in Vitro but Not in Patients in a Randomized Clinical Trial

Autor: Kiran Dole, Brigitte Wiedmann, Jin Chen, Edward Gane, Charles D. Meyers, Prakash Raman, Richard Colvin, Jin Zhang, Catherine A.M. Stedman

Publikováno v: ACS Infectious Diseases. 3:144-151

Hepatitis C virus (HCV) infection is a significant cause of liver disease affecting 80-150 million people globally. Diacylglycerol transferase 1 (DGAT-1), a triglyceride synthesis enzyme, is important for the HCV life cycle in vitro. Pradigastat, a p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3a4b17815da71ed543995560fcd6424
https://doi.org/10.1021/acsinfecdis.6b00138

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2-Alkyloxazoles as potent and selective PI4KIIIβ inhibitors demonstrating inhibition of HCV replication

Autor: Michael D. Connolly, Matthew J. LaMarche, Lawrence G. Hamann, Ayako Honda, Brigitte Wiedmann, Subramanian Karur, Shawn D. Britt, Markus Dobler, Rajeshri Ganesh Karki, Prakash Raman, Anup Patnaik, Samantha Sokup, Erin P. Keaney

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 24:3714-3718

Synthesis and SAR of 2-alkyloxazoles as class III phosphatidylinositol-4-kinase beta (PI4KIIIβ) inhibitors is described. These compounds demonstrate that inhibition of PI4KIIIβ leads to potent inhibition of HCV replication as observed in genotype (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd89a1f44474311f1155702c2f42685c
https://doi.org/10.1016/j.bmcl.2014.07.015

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Akademický článek

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Identification and characterization of 4-aryl-3,4-dihydropyrimidin-2(1H)-ones as inhibitors of the fatty acid transporter FATP4

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 16:3504-3509

Several potent, cell permeable 4-aryl-dihydropyrimidinones have been identified as inhibitors of FATP4. Lipophilic ester substituents at the 5-position and substitution at the para-position (optimal groups being -NO(2) and CF(3)) of the 4-aryl group

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c36d93f16e441b5baeefceacd3db7a72
https://doi.org/10.1016/j.bmcl.2006.03.102

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Titanium(IV)-Mediated Tandem Deprotection−Cyclodehydration of Protected Cysteine N-Amides: Biomimetic Syntheses of Thiazoline- and Thiazole-Containing Heterocycles

Autor: Jeffery W. Kelly, Prakash Raman, Hossein Razavi

Publikováno v: Organic Letters. 2:3289-3292

The scope and limitations of TiCl(4)-mediated Delta(2)-thiazoline synthesis via tandem deprotection-dehydrocyclization of trityl-protected cysteine N-amides is presented. While chemical yields are acceptable (53-96%), the stereochemical outcomes vary

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8f793e7417449989cb8b5ebe61bf5f0
https://doi.org/10.1021/ol000178q

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[Untitled]

Autor: Thomas Klabunde, Prakash Raman, V.B. Oza, James C. Sacchettini, Jeffery W. Kelly, H M Petrassi

Publikováno v: Nature Structural Biology. 7:312-321

The human amyloid disorders, familial amyloid polyneuropathy, familial amyloid cardiomyopathy and senile systemic amyloidosis, are caused by insoluble transthyretin (TTR) fibrils, which deposit in the peripheral nerves and heart tissue. Several nonst

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b54a73078f0648d2eb987e2eb5c4d4f1
https://doi.org/10.1038/74082

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A macrocyclic HCV NS3/4A protease inhibitor interacts with protease and helicase residues in the complex with its full-length target

Autor: Gaby Monnet, Ulrich Hassiepen, Dmitri I. Svergun, Frederic Villard, Nikolaus Schiering, Jörg Eder, Allan D'Arcy, Marion Kamke, Ursula Bodendorf, Prakash Raman, Oliver Simic, Ruth Pulfer

Hepatitis C virus (HCV) infection is a global health burden with over 170 million people infected worldwide. In a significant portion of patients chronic hepatitis C infection leads to serious liver diseases, including fibrosis, cirrhosis, and hepato

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8477bebbbfaf660ca3ddc2f2947b2bdc
https://europepmc.org/articles/PMC3248494/

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