Výsledky vyhledávání - "Prakash C. Jha"

Akademický článek

Highly efficient synthesis of isoxazolones and pyrazolones using g-C3N4·OH nanocomposite with their in silico molecular docking, pharmacokinetics and simulation studies

Autor: Shivani Soni, Sunita Teli, Pankaj Teli, Anu Manhas, Prakash C. Jha, Shikha Agarwal

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-22 (2024)

Abstract An environmentally friendly, versatile multicomponent reaction for synthesizing isoxazol-5-one and pyrazol-3-one derivatives has been developed, utilizing a freshly prepared g-C3N4· OH nanocomposite as a highly efficient catalyst at room te

Externí odkaz: https://doaj.org/article/81052fd350b1422b968fb22cb14e4a40

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Akademický článek

Experimental and computational characterization of p-Sulfocalix[4]arene mediated delivery system for morin hydrate

Autor: Sunaina Chaurasiya, Raghu Solanki, Mohd Athar, Ashok Kumar Jangid, Sunita Patel, Prakash C. Jha, Deep Pooja, Hitesh Kulhari

Publikováno v: Medicine in Drug Discovery, Vol 22, Iss , Pp 100180- (2024)

Calix[n]arene is a class of macrocyclic compounds and has been investigated to improve the physicochemical properties of water insoluble molecules. In this work, a complex of morin hydrate (MH) drug was prepared using p-sulfocalix[4]arene (SC[4]A) as

Externí odkaz: https://doaj.org/article/cd5f639250c342f8afaf4f777235789e

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Akademický článek

Targeting allosteric binding site in methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) to identify natural product inhibitors via structure-based computational approach

Autor: Nisarg Rana, Dhaval Patel, Meet Parmar, Nandini Mukherjee, Prakash C. Jha, Anu Manhas

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-22 (2023)

Abstract Cancer has been viewed as one of the deadliest diseases worldwide. Among various types of cancer, breast cancer is the most common type of cancer in women. Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) is a promising druggable target an

Externí odkaz: https://doaj.org/article/75c1638ccbbc4faf9dc307937ff1f25c

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Akademický článek

Glycerol based carbon sulfonic acid catalyzed synthesis, in silico studies and in vitro biological evaluation of isonicotinohydrazide derivatives as potent antimicrobial and anti-tubercular agents

Autor: Ayushi Sethiya, Deepkumar Joshi, Anu Manhas, Nusrat Sahiba, Dinesh K. Agarwal, Prakash C. Jha, Shikha Agarwal

Publikováno v: Heliyon, Vol 9, Iss 2, Pp e13226- (2023)

The present pathway involves synthesis of isonicotinohydrazide derivatives using isoniazid and diversely substituted aldehydes in the presence of EtOH and catalytic amount of glycerol based carbon sulfonic acid catalyst. The developed pathway has so

Externí odkaz: https://doaj.org/article/de9609e335f8484a831e312a16fd0f26

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Akademický článek

A multi-objective fuzzy mathematical approach for sustainable reverse supply chain configuration

Autor: Jyoti D. Darbari, Vernika Agarwal, Venkata S.S. Yadavalli, Diego Galar, Prakash C. Jha

Publikováno v: Journal of Transport and Supply Chain Management, Vol 11, Iss 0, Pp e1-e12 (2017)

Background: Designing and implementation of reverse logistics (RL) network which meets the sustainability targets have been a matter of emerging concern for the electronics companies in India. Objectives: The present study developed a two-phase mode

Externí odkaz: https://doaj.org/article/934f70a5c267480d8205a70e2c4d3ec6

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Reckoning apigenin and kaempferol as a potential multi-targeted inhibitor of EGFR/HER2-MEK pathway of metastatic colorectal cancer identified using rigorous computational workflow

Autor: Abhilasha Sharma, Sonam Sinha, Pooja Rathaur, Jaykant Vora, Prakash C. Jha, Kaid Johar, Rakesh M. Rawal, Neeta Shrivastava

Publikováno v: Molecular Diversity. 26:3337-3356

In the past two decades, the treatment of metastatic colorectal cancer (mCRC) has been revolutionized as multiple cytotoxic, biological, and targeted drugs are being approved. Unfortunately, tumors treated with single targeted agents or therapeutics

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e5c722dfaf04d017f2ea2af221e7c18
https://doi.org/10.1007/s11030-022-10396-7

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Structural differences in 3C-like protease (Mpro) from SARS-CoV and SARS-CoV-2: molecular insights revealed by Molecular Dynamics Simulations

Autor: Meet Parmar, Ritik Thumar, Bhumi Patel, Mohd Athar, Prakash C. Jha, Dhaval Patel

Publikováno v: Structural Chemistry.

Novel coronavirus SARS-CoV-2 has infected millions of people with thousands of mortalities globally. The main protease (Mpro) is vital in processing replicase polyproteins. Both the CoV's Mpro shares 97% identity, with 12 mutations, but none are pres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bac732da53c2b39baf8076146f9206ed
https://doi.org/10.1007/s11224-022-02089-6

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