Výsledky vyhledávání - "Prakash Bhakuni"

CTLA4Ig in an Extended Schedule along with Sirolimus Improves Outcome with a Distinct Pattern of Immune Reconstitution Following Post-Transplantation Cyclophosphamide-Based Haploidentical Transplantation for Hemoglobinopathies

Autor: Satish Bansal, Prakash Bhakuni, Hema Malini Aiyer, Sarita Rani Jaiswal, Mayank Soni, Suparno Chakrabarti

Publikováno v: Biology of Blood and Marrow Transplantation. 26:1469-1476

The major hindrances to the success of a haploidentical hematopoietic cell transplantation for hemoglobinopathies are graft failure, early post-transplant hemophagocytic syndrome (PTHPS), and graft-versus-host disease (GVHD). Following the successful

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43535d6cf3cda0c8f5ebbb5dcb88a555
https://doi.org/10.1016/j.bbmt.2020.05.005

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Alterations in NKG2A and NKG2C Subsets of Natural Killer Cells Following Epstein–Barr Virus Reactivation in CTLA4Ig-based Haploidentical Transplantation Is Associated With Increased Chronic Graft-Versus-Host Disease

Autor: Sarita Rani Jaiswal, Prakash Bhakuni, Suparno Chakrabarti, Aditi Chakrabarti, Hema Malini Aiyar, Gitali Bhagwati

Publikováno v: Transplantation. 104:e23-e30

BACKGROUND The impact of newer approaches to haploidentical transplantation on Epstein-Barr virus (EBV) is largely unknown. METHODS We prospectively evaluated the incidence of EBV reactivation and its impact on transplantation outcomes in 71 patients

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e5c6207fb4adb7921135a6ecb2d68b7
https://doi.org/10.1097/tp.0000000000002941

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Impact of Preemptive Granulocyte Infusions During Febrile Neutropenia in Patients Colonized with Carbapenem-Resistant Gram-Negative Bacteria Undergoing Haploidentical Transplantation

Autor: Aditi Chakrabarti, Aby Joy, Sarita Rani Jaiswal, Prakash Bhakuni, Suparno Chakrabarti, Gitali Bhagwati

Publikováno v: Biology of Blood and Marrow Transplantation. 25:1621-1628

We prospectively studied the impact of preemptive granulocyte infusions (pGIs) in 69 patients colonized with carbapenem-resistant gram-negative bacteria (CRGNB) undergoing haploidentical hematopoietic cell transplantation (HCT) compared with a previo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf545b5cec0f96e9b89fc020956caf28
https://doi.org/10.1016/j.bbmt.2019.04.023

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Safety and efficacy of Sofosbuvir and Velpatasvir in children with active hepatitis C virus infection undergoing haploidentical transplantation

Autor: Sarita Rani Jaiswal, Prakash Bhakuni, Atul Thatai, Mahesh Gupta, Suparno Chakrabarti, Mayank Soni

Publikováno v: Transplant infectious disease : an official journal of the Transplantation SocietyREFERENCES. 23(2)

Direct Acting Antivirals (DAA) have changed the landscape of hepatitis C virus (HCV) infection with high cure rates across genotypes. However, the use of these agents in the setting of allogeneic hematopoietic cell transplantation (HCT) has been limi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8b1737009dc7bff967f238aeae61ea6
https://pubmed.ncbi.nlm.nih.gov/33037697

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CTLA4Ig-primed donor lymphocyte infusions following haploidentical transplantation improve outcome with a distinct pattern of early immune reconstitution as compared to conventional donor lymphocyte infusions in advanced hematological malignancies

Autor: Hema Malini Aiyer, Aditi Chakrabarti, Gitali Bhagawati, Sarita Rani Jaiswal, Prakash Bhakuni, Mayank Soni, Rishabh Raj Jaiswal, Suparno Chakrabarti, Navneet Sharma

Publikováno v: Bone marrow transplantation. 56(1)

CTLA4Ig has a unique property to spare or even potentiate natural killer (NK) cell-mediated cytotoxicity, whilst inhibiting T cell activation. We explored the efficacy of prophylactic DLI following CTLA4Ig (CTLA4Ig-DLI group, n = 75), compared to con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7732e492ce95e8aaa8cd4aa5328e72d7
https://pubmed.ncbi.nlm.nih.gov/32704091

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Higher CD45RA+ Regulatory T Cells in the Graft Improves Outcome in Younger Patients Undergoing T Cell–Replete Haploidentical Transplantation: Where Donor Age Matters

Autor: Sarita Rani Jaiswal, Nisha Murli, Aby Joy, Aditi Chakrabarti, Prakash Bhakuni, Ashok Rajoreya, Suparno Chakrabarti

Publikováno v: Biology of Blood and Marrow Transplantation. 24:2025-2033

To understand the phenomenon of early alloreactivity (EA) in younger children undergoing post-transplantation cyclophosphamide (PTCy)-based haploidentical transplantation, we studied the graft composition and the immune reconstitution in 32 consecuti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::256f1d77ccaeda750840c31c61f9756c
https://doi.org/10.1016/j.bbmt.2018.06.003

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T cell costimulation blockade promotes transplantation tolerance in combination with sirolimus and post-transplantation cyclophosphamide for haploidentical transplantation in children with severe aplastic anemia

Autor: Sneh Bhargava, Priyanka Bharadwaj, Satish Bansal, Sarita Rani Jaiswal, Suparno Chakrabarti, Shamsuz Zaman, Prakash Bhakuni

Publikováno v: Transplant Immunology. :54-59

We conducted a pilot study employing extended T cell costimulation blockade (COSBL) with Abatacept along with sirolimus and post-transplantation cyclophosphamide (PTCy) in 10 patients (median age 12) with severe aplastic anemia (SAA). Nine patients e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78513c99ebc93789cfcc3d5f70b7fce9
https://doi.org/10.1016/j.trim.2017.07.004

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