Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Prakash B. Palde"'
Autor:
Karen A. Maegley, Kephart Susan Elizabeth, Christopher P. Dillon, Manli Shi, Kristen Jensen-Pergakes, Prakash B. Palde, Ya-Li Deng, Chi-Yeh Chung, Natalie Miller, John Sherrill, Wei Liu, Ryan L. Patman, Shinji Yamazaki, Tao Xie, Fen Wang, Hieu Lam, Eleanore Hendrickson, John F. Braganza, Yuli Wang, Robert Arnold Kumpf, Shannon Karlicek Bryant, Thomas A Paul, Noah Spiegel, Martin James Wythes, Amy Nemeth, Stephanie Scales, Elizabeth A. McMillan, Michelle Tran-Dubé, Alexei Brooun, Vesta Goshtasbi, Eugene Rui, Michele McTigue, Indrawan James Mcalpine, Tatlock John H
Publikováno v:
Molecular Cancer Therapeutics. 21:3-15
Protein arginine methyltransferase 5 (PRMT5) overexpression in hematologic and solid tumors methylates arginine residues on cellular proteins involved in important cancer functions including cell-cycle regulation, mRNA splicing, cell differentiation,
Autor:
Paul G. Richardson, Xiaoyun Meng, Karen A. Maegley, A.E. Stewart, Pei-Pei Kung, Jose L Montano, Ya-Li Deng, Jinqiao Wan, Michael R. Gehring, Jordan L. Meier, Brigitte S Naughton, Stephan Grant, Dou Dengfeng, Chakrapani Subramanyam, Anthony R. Harris, Samantha Elizabeth Greasley, Barry A. Morgan, Wen Yan, Xuemin Cheng, Prakash B. Palde, William K Sonnenburg, Junli Feng, Chen Qiuxia, Thomas A Paul, Gary M. Gallego, Sylvie K. Sakata, Sergei Timofeevski, Patrick Bingham, Benjamin J. Burke, Alex Shaginian
Publikováno v:
ACS Med Chem Lett
[Image: see text] Two novel compounds were identified as Naa50 binders/inhibitors using DNA-encoded technology screening. Biophysical and biochemical data as well as cocrystal structures were obtained for both compounds (3a and 4a) to understand thei
Autor:
Ben Bolaňos, Sherry Niessen, Martha A. Ornelas, Paulina Delgado Cuenca, Douglas Carl Behenna, Lawrence G. Lum, Prakash B. Palde, Tran Khanh Tuan, Kevin Ryan, Stephen Kaiser, Marissa Smith, Lianglin Zhang, Todd VanArsdale, Al Stewart, Ketan S. Gajiwala
Publikováno v:
The Journal of Biological Chemistry
Poly-ADP-ribosyltransferases play a critical role in DNA repair and cell death, and poly(ADP-ribosyl) polymerase 1 (PARP1) is a particularly important therapeutic target for the treatment of breast cancer because of its synthetic lethal relationship
Autor:
Eleanore Hendrickson, Martin James Wythes, Indrawan James Mcalpine, Karen A. Maegley, Christopher P. Dillon, Fen Wang, Kephart Susan Elizabeth, Amy Nemeth, Prakash B. Palde, Manli Shi, Kristen Jensen-Pergakes, Shinji Yamazaki, Tao Xie, Chi-Yeh Chung, Michelle Tran-Dubé, Tatlock John H, Stephanie Scales, Hieu Lam, Eugene Rui, Thomas A Paul, Elizabeth A. McMillan, Robert Arnold Kumpf, Ryan L. Patman, Michele McTigue, Natalie Miller, Ya-Li Deng, Yuli Wang, Noah Spiegel, Alexei Brooun, John Sherrill, Wei Liu, John F. Braganza
Publikováno v:
Cancer Research. 81:1160-1160
Protein arginine methyltransferase 5 (PRMT5) overexpression in hematological and solid tumors promotes symmetrical di-methyl arginine (SDMA) on cellular proteins involved in important cancer functions including cell cycle regulation, mRNA splicing, c
Publikováno v:
ChemBioChem. 17:1873-1878
In human pathogens, the sulphate assimilation pathway provides reduced sulphur for biosynthesis of essential metabolites including cysteine and low-molecular weight thiol compounds. Sulfonucleotide reductases (SRs) catalyze the first committed step o
Autor:
Kate S. Carroll, Laura E. Pedró Rosa, Franck Madoux, Louis Scampavia, Ashima Bhaskar, Timothy P. Spicer, Peter Chase, Prakash B. Palde, Vinayak Gupta, Amit Singh
Publikováno v:
ACS Chemical Biology. 11:172-184
Development of effective therapies to eradicate persistent, slowly replicating M. tuberculosis (Mtb) represents a significant challenge to controlling the global TB epidemic. To develop such therapies, it is imperative to translate information from m
Autor:
Kate S. Carroll, Prakash B. Palde, Thu H. Truong, Candice E. Paulsen, Avner Schlessinger, Peter Man-Un Ung
Publikováno v:
Cell chemical biology. 23(7)
Epidermal growth factor receptor (EGFR) is a target of signal-derived H2O2, and oxidation of active-site cysteine 797 to sulfenic acid enhances kinase activity. Although a major class of covalent drugs targets C797, nothing is known about its catalyt
Autor:
Prakash B. Palde, Timothy F. Jamison
Publikováno v:
Prof. Jamison via Erja Kajosalo
Safer flow: The synthesis of 5-substituted tetrazoles in flow (see scheme) is safe, efficient, scalable, requires no metal promoter, and uses a near-equimolar amount of NaN[subscript 3], yet nonetheless displays a broad substrate scope. The hazards a
Autor:
Krzysztof Sobczak, Benjamin L. Miller, Charles A. Thornton, Peter C. Gareiss, Prakash B. Palde, Brian R. McNaughton
Publikováno v:
Journal of the American Chemical Society. 130:16254-16261
Myotonic dystrophy type 1 (DM1), the most common form of muscular dystrophy in adults, is an RNA-mediated disease. Dramatically expanded (CUG) repeats accumulate in nuclei and sequester RNA-binding proteins such as the splicing regulator MBNL1. We ha
Autor:
Benjamin L. Miller, Brian R. McNaughton, Peter C. Gareiss, Prakash B. Palde, Charles R. Mace, Nathan T. Ross, Robert C. Spitale
Publikováno v:
Synthesis. 2007:2287-2290
A key goal of synthetic organic chemistry is the preparation of functional molecules from simple starting materials as expeditiously as possible. Building on our efforts to construct tripodal receptors featuring a cis-1,3,5-cyclohexane core, we have