Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Prajwal Rajappa"'
Autor:
Rituraj Upadhyay, MD, Joshua D. Palmer, MD, Brett G. Klamer, PhD, Haley K. Perlow, MD, Jonathan E. Schoenhals, MD, Jayeeta Ghose, PhD, Prajwal Rajappa, MD, Dukagjin M. Blakaj, MD, PhD, Sasha Beyer, MD, PhD, John C. Grecula, MD, Austin J. Sim, MD, JD, Lanchun Lu, PhD, Wesley Zoller, CMD, James B. Elder, MD, Arnab Chakravarti, MD, Evan Thomas, MD, PhD, Raju R. Raval, MD, DPhil
Publikováno v:
Advances in Radiation Oncology, Vol 9, Iss 7, Pp 101509- (2024)
Background: Current standard of care treatment for patients with ≥15 brain metastases (BM) is whole brain radiation therapy (WBRT), despite poor neurocognitive outcomes. We analyzed our institutional experience of treating these patients with stere
Externí odkaz:
https://doaj.org/article/9fda9edbc167416695cdd17b6b58a474
Autor:
Matthew Nazzaro, Alessandro Canella, Claire Schmitt, Abigail Haffey, Giovanni Nigita, Gregory K Behbehani, Prajwal Rajappa
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/1828a68109d343cf9cf106f4b381f851
Autor:
Alessandro Canella, Matthew Nazzaro, Sakthi Rajendran, Claire Schmitt, Abigail Haffey, Giovanni Nigita, Diana Thomas, Justin M. Lyberger, Gregory K. Behbehani, Nduka M. Amankulor, Elaine R. Mardis, Timothy P. Cripe, Prajwal Rajappa
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112891- (2023)
Summary: Gliomas are one of the leading causes of cancer-related death in the adolescent and young adult (AYA) population. Two-thirds of AYA glioma patients are affected by low-grade gliomas (LGGs), but there are no specific treatments. Malignant pro
Externí odkaz:
https://doaj.org/article/30306653fadb443a81cc1ac3965bc482
Autor:
Tyler J. Alban, Matthew M. Grabowski, Balint Otvos, Defne Bayik, Wesley Wang, Ajay Zalavadia, Vlad Makarov, Katie Troike, Mary McGraw, Anja Rabljenovic, Adam Lauko, Chase Neumann, Gustavo Roversi, Kristin A. Waite, Gino Cioffi, Nirav Patil, Thuy T. Tran, Kathleen McCortney, Alicia Steffens, C. Marcela Diaz, J. Mark Brown, Kathleen M. Egan, Craig M. Horbinski, Jill S. Barnholtz-Sloan, Prajwal Rajappa, Michael A. Vogelbaum, Richard Bucala, Timothy A. Chan, Manmeet S. Ahluwalia, Justin D. Lathia
Publikováno v:
JCI Insight, Vol 8, Iss 13 (2023)
Intratumoral heterogeneity is a defining hallmark of glioblastoma, driving drug resistance and ultimately recurrence. Many somatic drivers of microenvironmental change have been shown to affect this heterogeneity and, ultimately, the treatment respon
Externí odkaz:
https://doaj.org/article/235cfdd3465841ec8a0ca9c96d6c14cb
Autor:
Sakthi Rajendran, Yang Hu, Alessandro Canella, Clayton Peterson, Amy Gross, Maren Cam, Matthew Nazzaro, Abigail Haffey, Akdes Serin-Harmanci, Rosario Distefano, Giovanni Nigita, Wesley Wang, Daniel Kreatsoulas, Zihai Li, Jesse A. Sepeda, Andrew Sas, Mark E. Hester, Katherine E. Miller, Olivier Elemento, Ryan D. Roberts, Eric C. Holland, Ganesh Rao, Elaine R. Mardis, Prajwal Rajappa
Publikováno v:
Cell Reports, Vol 42, Iss 3, Pp 112197- (2023)
Summary: Recent studies have shown the importance of the dynamic tumor microenvironment (TME) in high-grade gliomas (HGGs). In particular, myeloid cells are known to mediate immunosuppression in glioma; however, it is still unclear if myeloid cells p
Externí odkaz:
https://doaj.org/article/4c475f0d1a224421a34de4bf6fa862d6
Autor:
Payal Aggarwal, Wen Luo, Katherine C. Pehlivan, Hai Hoang, Prajwal Rajappa, Timothy P. Cripe, Kevin A. Cassady, Dean A. Lee, Mitchell S. Cairo
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
High grade gliomas are identified as malignant central nervous tumors that spread rapidly and have a universally poor prognosis. Historically high grade gliomas in the pediatric population have been treated similarly to adult high grade gliomas. For
Externí odkaz:
https://doaj.org/article/59aa2ba0d016490c89b1120c5578edcc
Autor:
Thomas Reiner, Mark M. Souweidane, Wolfgang A. Weber, David Pisapia, Kayvan R. Keshari, Prajwal Rajappa, Uday B. Maachani, Vesselin Z. Miloushev, Giuseppe Carlucci, Melanie Schweitzer, Brandon Carney, Susanne Kossatz
Monitoring tumor growth using [18F]PARPi. Display of weekly imaging of tumor development in adult ntv-a;p53fl/fl mice at the indicated time after DF1 cell injection. PET/CT imaging was always conducted 2 h p.i. of [18F]PARPi. Animals were sacrificed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f4b045090394ce35e9570ea1c0e71a8
https://doi.org/10.1158/0008-5472.22416185
https://doi.org/10.1158/0008-5472.22416185
Autor:
Thomas Reiner, Mark M. Souweidane, Wolfgang A. Weber, David Pisapia, Kayvan R. Keshari, Prajwal Rajappa, Uday B. Maachani, Vesselin Z. Miloushev, Giuseppe Carlucci, Melanie Schweitzer, Brandon Carney, Susanne Kossatz
Chemical structures of PARPi-FL and [18F]PARPi. We developed a fluorescent ("PARPi-FL") (a) and 18F-labelled ("[18F]PARPi") (b) version of a PARP1 targeted small molecule, based on the structure of Olaparib23, 26, 27. Mouse and human PARP1 are orthol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51d16a7aed988747ebb0102a116adacd
https://doi.org/10.1158/0008-5472.22416200.v1
https://doi.org/10.1158/0008-5472.22416200.v1
Autor:
Thomas Reiner, Mark M. Souweidane, Wolfgang A. Weber, David Pisapia, Kayvan R. Keshari, Prajwal Rajappa, Uday B. Maachani, Vesselin Z. Miloushev, Giuseppe Carlucci, Melanie Schweitzer, Brandon Carney, Susanne Kossatz
Biodistribution of [18F]PARPi in healthy ntv-a;p53fl/fl mice 2 h p.i.. Animals were injected with [18F]PARPi 2 hours prior to the biodistribution study (n=4). To control for uptake specificity, one group (n=4) was injected with 1 mg Olaparib 30min pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9233012d95872fb8a04cbde379142f8a
https://doi.org/10.1158/0008-5472.22416188
https://doi.org/10.1158/0008-5472.22416188
Autor:
Thomas Reiner, Mark M. Souweidane, Wolfgang A. Weber, David Pisapia, Kayvan R. Keshari, Prajwal Rajappa, Uday B. Maachani, Vesselin Z. Miloushev, Giuseppe Carlucci, Melanie Schweitzer, Brandon Carney, Susanne Kossatz
Histological characterization of GEMM tumor model and PARPi-FL localization. (a) The GEMM model showed heterogenous morphological characteristics, representing high grade areas (with necrotic features, high cellularity, microvascular proliferation) a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d91b51cc7cc1bb564848ec18af2f78b
https://doi.org/10.1158/0008-5472.22416197.v1
https://doi.org/10.1158/0008-5472.22416197.v1