Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Prajwal P, Nandekar"'
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Mukherjee, Nandekar and Wade investigate the structural arrangement of the complex between membrane-bound cytochrome P450 1A1 and NADPH-cytochrome P450 reductase. They find that upon binding to the reductase, the catalytic domain of cytochrome P450 1
Externí odkaz:
https://doaj.org/article/b6c55376663c4ca48528fe879b9a75a4
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 18, p 4328 (2019)
The human cytochrome P450 (CYP) 2C9 and 2C19 enzymes are two highly similar isoforms with key roles in drug metabolism. They are anchored to the endoplasmic reticulum membrane by their N-terminal transmembrane helix and interactions of their cytoplas
Externí odkaz:
https://doaj.org/article/c10f8c49592e46ce8e92766915999e25
Autor:
Rebecca C. Wade, Tyler Camp, Prajwal P. Nandekar, Neil J. Bruce, Ghulam Mustafa, Michael C. Gregory, Stephen G. Sligar
Publikováno v:
Biophysical Journal
Human cytochrome P450 (CYP) enzymes play an important role in the metabolism of drugs, steroids, fatty acids, and xenobiotics. Microsomal CYPs are anchored in the endoplasmic reticulum membrane by an N-terminal transmembrane (TM) helix that is connec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a0ef41f66ae5283732109357d5f705a
http://europepmc.org/articles/PMC6369400
http://europepmc.org/articles/PMC6369400
Publikováno v:
Communications Biology
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Cytochrome P450 (CYP) heme monooxygenases require two electrons for their catalytic cycle. For mammalian microsomal CYPs, key enzymes for xenobiotic metabolism and steroidogenesis and important drug targets and biocatalysts, the electrons are transfe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfc9fa06975441343ecdc8b68f88365d
https://pubmed.ncbi.nlm.nih.gov/33420418
https://pubmed.ncbi.nlm.nih.gov/33420418
Publikováno v:
International Journal of Molecular Sciences
Volume 20
Issue 18
International Journal of Molecular Sciences, Vol 20, Iss 18, p 4328 (2019)
Volume 20
Issue 18
International Journal of Molecular Sciences, Vol 20, Iss 18, p 4328 (2019)
The human cytochrome P450 (CYP) 2C9 and 2C19 enzymes are two highly similar isoforms with key roles in drug metabolism. They are anchored to the endoplasmic reticulum membrane by their N-terminal transmembrane helix and interactions of their cytoplas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d9cc0a613b45835307c93d8d34a3aef
http://europepmc.org/articles/PMC6770661
http://europepmc.org/articles/PMC6770661
Publikováno v:
High Performance Computing in Science and Engineering ' 18 ISBN: 9783030133245
We describe a transferable multiresolution computational approach to build and simulate complexes of two proteins—cytochrome P450 (CYP) and CYP reductase (CPR)—in a membrane bilayer using Brownian dynamics (BD) and all-atom molecular dynamics (MD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec7f27d6865f3ebd889e77e266eeb8f7
https://doi.org/10.1007/978-3-030-13325-2_32
https://doi.org/10.1007/978-3-030-13325-2_32
Autor:
Abhay T. Sangamwar, Roshan M. Borkar, Sanjay K. Banerjee, R. Srinivas, V. Ganga Reddy, Ahmed Kamal, Murali Mohan Bhandi, Ajay P. Dubey, Prashanth Komirishetty, Prajwal P. Nandekar
Publikováno v:
Biomedical Chromatography. 30:1556-1572
The aim of the present study was to evaluate the contribution of metabolites to drug-drug interaction and drug-herb interaction using the inhibition of CYP2D6 and CYP3A4 by metoprolol (MET) and its metabolites. The peak concentrations of unbound plas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0da94130bf3b991231ec0d687f87c437
https://doi.org/10.1002/bmc.3721
https://doi.org/10.1002/bmc.3721
Autor:
Preeti Pragyan, Prajwal P. Nandekar, Abhay T. Sangamwar, Vijay Rathod, Siddharth S. Kesharwani
Publikováno v:
Journal of Molecular Recognition. 29:370-390
Recent trends in new drug discovery of anticancer drugs have made oncologists more aware of the fact that the new drug discovery must target the developing mechanism of tumorigenesis to improve the therapeutic efficacy of antineoplastic drugs. The dr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::92fee72eb0ec42b16e34e01b8f623b72
https://doi.org/10.1002/jmr.2537
https://doi.org/10.1002/jmr.2537
Autor:
Xiaofeng Yu, Prajwal P. Nandekar, Galina I. Lepesheva, Rebecca C. Wade, Vlad Cojocaru, Ghulam Mustafa
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1860:67-78
Background Cytochrome P450 sterol 14α-demethylase (CYP51) is an essential enzyme for sterol biosynthesis and a target for anti-parasitic drug design. However, the design of parasite-specific drugs that inhibit parasitic CYP51 without severe side eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a037dcf39a2671247736075f8554e3e
https://doi.org/10.1016/j.bbagen.2015.10.015
https://doi.org/10.1016/j.bbagen.2015.10.015
Autor:
Abhay T. Sangamwar, Subhash Mohan Agarwal, Prajwal P. Nandekar, Vishnu K. Sharma, Horacio Pérez-Sánchez
Publikováno v:
RSC Advances. 6:65725-65735
Epidermal growth factor receptor (EGFR) is an important validated drug target for cancer therapy. Some therapeutic agents targeting EGFR have been developed, however these are sometimes ineffective, which calls for the discovery of alternative novel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3fa4b9fa23b443c3342f8a23526f3d93
https://doi.org/10.1039/c6ra08517b
https://doi.org/10.1039/c6ra08517b