The synthetic TLR2 agonist BPPcysMPEG leads to efficient cross-priming against co-administered and linked antigens

Autor: Prajeeth, CK, Jirmo, AC, Krishnaswamy, JK, Ebensen, T, Guzman, CA, Weiss, S, Constabel, H, Schmidt, RE, Behrens, GM

The property of dendritic cells (DC) to generate effective cytotoxic T lymphocyte (CTL) responses is influenced by Toll-like Receptor (TLR) signalling. TLR ligands contain molecular signatures associated with pathogens, are being exploited as potenti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ef05475f3acdda6cac821bf3c51cd87

Safety and immunogenicity of the live-attenuated hRVFV-4s vaccine against Rift Valley fever in healthy adults: a dose-escalation, placebo-controlled, first-in-human, phase 1 randomised clinical trial.

Autor: Leroux-Roels I; Center for Vaccinology, Ghent University and Ghent University Hospital, Ghent, Belgium., Prajeeth CK; Research Center for Emerging Infections and Zoonoses, University of Veterinary Medicine, Hannover, Germany., Aregay A; Research Center for Emerging Infections and Zoonoses, University of Veterinary Medicine, Hannover, Germany., Nair N; Research Center for Emerging Infections and Zoonoses, University of Veterinary Medicine, Hannover, Germany., Rimmelzwaan GF; Research Center for Emerging Infections and Zoonoses, University of Veterinary Medicine, Hannover, Germany., Osterhaus ADME; Research Center for Emerging Infections and Zoonoses, University of Veterinary Medicine, Hannover, Germany; CR2O, Maarssen, Netherlands., Kardinahl S; IDT Biologika, Dessau-Rosslau, Germany., Pelz S; IDT Biologika, Dessau-Rosslau, Germany., Bauer S; IDT Biologika, Dessau-Rosslau, Germany., D'Onofrio V; Center for Vaccinology, Ghent University and Ghent University Hospital, Ghent, Belgium., Alhatemi A; Center for Vaccinology, Ghent University and Ghent University Hospital, Ghent, Belgium., Jacobs B; Center for Vaccinology, Ghent University and Ghent University Hospital, Ghent, Belgium., De Boever F; Center for Vaccinology, Ghent University and Ghent University Hospital, Ghent, Belgium., Porrez S; Center for Vaccinology, Ghent University and Ghent University Hospital, Ghent, Belgium., Waerlop G; Center for Vaccinology, Ghent University and Ghent University Hospital, Ghent, Belgium., Punt C; BunyaVax, Lelystad, Netherlands., Hendriks B; CR2O, Maarssen, Netherlands., von Mauw E; CR2O, Maarssen, Netherlands., van de Water S; Wageningen Bioveterinary Research, Lelystad, Netherlands., Harders-Westerveen J; Wageningen Bioveterinary Research, Lelystad, Netherlands., Rockx B; Wageningen Bioveterinary Research, Lelystad, Netherlands., van Keulen L; Wageningen Bioveterinary Research, Lelystad, Netherlands., Kortekaas J; Wageningen Bioveterinary Research, Lelystad, Netherlands., Leroux-Roels G; Center for Vaccinology, Ghent University and Ghent University Hospital, Ghent, Belgium., Wichgers Schreur PJ; BunyaVax, Lelystad, Netherlands; Wageningen Bioveterinary Research, Lelystad, Netherlands. Electronic address: paul.wichgersschreur@wur.nl.

Publikováno v: The Lancet. Infectious diseases [Lancet Infect Dis] 2024 Nov; Vol. 24 (11), pp. 1245-1253. Date of Electronic Publication: 2024 Jul 25.

Rift Valley Fever Virus-Infection, Pathogenesis and Host Immune Responses.

Autor: Nair N; Research Center for Emerging Infections and Zoonoses, University of Veterinary Medicine Hannover, Foundation, 30559 Hannover, Germany., Osterhaus ADME; Research Center for Emerging Infections and Zoonoses, University of Veterinary Medicine Hannover, Foundation, 30559 Hannover, Germany., Rimmelzwaan GF; Research Center for Emerging Infections and Zoonoses, University of Veterinary Medicine Hannover, Foundation, 30559 Hannover, Germany., Prajeeth CK; Research Center for Emerging Infections and Zoonoses, University of Veterinary Medicine Hannover, Foundation, 30559 Hannover, Germany.

Publikováno v: Pathogens (Basel, Switzerland) [Pathogens] 2023 Sep 19; Vol. 12 (9). Date of Electronic Publication: 2023 Sep 19.

β-Propiolactone (BPL)-inactivation of SARS-Co-V-2: In vitro validation with focus on saliva from COVID-19 patients for scent dog training.

Autor: Pilchová V; Research Center for Emerging Infections and Zoonoses, University of Veterinary Medicine Hannover, Hanover, Germany., Prajeeth CK; Research Center for Emerging Infections and Zoonoses, University of Veterinary Medicine Hannover, Hanover, Germany., Jendrny P; Department of Small Animal Medicine and Surgery, University of Veterinary Medicine Hannover, Hanover, Germany., Twele F; Department of Small Animal Medicine and Surgery, University of Veterinary Medicine Hannover, Hanover, Germany., Meller S; Department of Small Animal Medicine and Surgery, University of Veterinary Medicine Hannover, Hanover, Germany., Pink I; Department of Respiratory Medicine, Hannover Medical School, Carl-Neuberg-Straße 1, Hanover, Germany., Fathi A; Institute for Infection Research and Vaccine Development (IIRVD), University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Ist Department of Medicine, Division of Infectious Diseases, University Medical-Center Hamburg-Eppendorf, Hamburg, Germany; Department for Clinical Immunology of Infectious Diseases, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany; German Center for Infection Research, Hamburg-Lübeck, Borstel-Riems, Germany., Addo MM; Institute for Infection Research and Vaccine Development (IIRVD), University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Ist Department of Medicine, Division of Infectious Diseases, University Medical-Center Hamburg-Eppendorf, Hamburg, Germany; Department for Clinical Immunology of Infectious Diseases, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany; German Center for Infection Research, Hamburg-Lübeck, Borstel-Riems, Germany., Volk HA; Department of Small Animal Medicine and Surgery, University of Veterinary Medicine Hannover, Hanover, Germany., Osterhaus A; Research Center for Emerging Infections and Zoonoses, University of Veterinary Medicine Hannover, Hanover, Germany., von Köckritz-Blickwede M; Research Center for Emerging Infections and Zoonoses, University of Veterinary Medicine Hannover, Hanover, Germany; Department of Biochemistry, University of Veterinary Medicine Hannover, Hanover, Germany., Schulz C; Research Center for Emerging Infections and Zoonoses, University of Veterinary Medicine Hannover, Hanover, Germany. Electronic address: claudia.schulz@tiho-hannover.de.

Publikováno v: Journal of virological methods [J Virol Methods] 2023 Jul; Vol. 317, pp. 114733. Date of Electronic Publication: 2023 Apr 15.

Transient Blockade of Type I Interferon Signalling Promotes Replication of Dengue Virus Strain D2Y98P in Adult Wild-Type Mice.

Autor: Wilken L; Research Center for Emerging Infections and Zoonoses (RIZ), University of Veterinary Medicine (TiHo), 30559 Hannover, Germany., Stelz S; Research Center for Emerging Infections and Zoonoses (RIZ), University of Veterinary Medicine (TiHo), 30559 Hannover, Germany., Prajeeth CK; Research Center for Emerging Infections and Zoonoses (RIZ), University of Veterinary Medicine (TiHo), 30559 Hannover, Germany., Rimmelzwaan GF; Research Center for Emerging Infections and Zoonoses (RIZ), University of Veterinary Medicine (TiHo), 30559 Hannover, Germany.

Publikováno v: Viruses [Viruses] 2023 Mar 23; Vol. 15 (4). Date of Electronic Publication: 2023 Mar 23.