Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Prajal H Patel"'
Autor:
Emily L Rivard, Andrew G Ludwig, Prajal H Patel, Anna Grandchamp, Sarah E Arnold, Alina Berger, Emilie M Scott, Brendan J Kelly, Grace C Mascha, Erich Bornberg-Bauer, Geoffrey D Findlay
Publikováno v:
PLoS Genetics, Vol 17, Iss 9, p e1009787 (2021)
Comparative genomics has enabled the identification of genes that potentially evolved de novo from non-coding sequences. Many such genes are expressed in male reproductive tissues, but their functions remain poorly understood. To address this, we con
Externí odkaz:
https://doaj.org/article/914a8daee7114d5e9ee0eb6c73a363ec
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0150291 (2016)
Non-translating RNAs that have undergone active translational repression are culled from the cytoplasm into P-bodies for decapping-dependent decay or for sequestration. Organisms that use microRNA-mediated RNA silencing have an additional pathway to
Externí odkaz:
https://doaj.org/article/22ce259860a74e37ad2b0a34ade62dae
Autor:
Anna Grandchamp, Emilie M. Scott, Geoffrey D. Findlay, Prajal H. Patel, Erich Bornberg-Bauer, Emily L Rivard, Grace C. Mascha, Sarah E. Arnold, Andrew G. Ludwig, Brendan J Kelly, Alina Berger
Comparative genomics has enabled the identification of genes that potentially evolved de novo from non-coding sequences. Many such genes are expressed in male reproductive tissues, but their functions remain poorly understood. To address this, we con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70300ea601512a4c40290f133fdec4ae
https://doi.org/10.1101/2021.06.10.447990
https://doi.org/10.1101/2021.06.10.447990
Autor:
Erich Bornberg-Bauer, Geoffrey D. Findlay, Adam M. Damry, Thorsten Saenger, Andreas Lange, Brennen Heames, Colin J. Jackson, Prajal H. Patel
Comparative genomic studies have repeatedly shown that new protein-coding genes can emerge de novo from non-coding DNA. Still unknown is how and when the structures of encoded de novo proteins emerge and evolve. Combining biochemical, genetic and evo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5784d89aa8b065b1e559cc369b7d9702
https://doi.org/10.1101/2021.01.18.427054
https://doi.org/10.1101/2021.01.18.427054
Autor:
J. Todd Blankenship, Scott A. Barbee, Malea R. McGimsey, Emily L. Starke, Prajal H. Patel, Emily C. Wilkinson
Publikováno v:
Biology Open
article-version (VoR) Version of Record
Biology Open, Vol 9, Iss 8 (2020)
article-version (VoR) Version of Record
Biology Open, Vol 9, Iss 8 (2020)
Vps54 is a subunit of the Golgi-associated retrograde protein (GARP) complex, which is involved in tethering endosome-derived vesicles to the trans-Golgi network (TGN). In the wobbler mouse, a model for human motor neuron (MN) disease, reduction in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::475d9b0bef88a766ee346b5a6aefb520
http://europepmc.org/articles/PMC7473652
http://europepmc.org/articles/PMC7473652
Autor:
Emily C. Wilkinson, Malea R. McGimsey, Scott A. Barbee, Emily L. Starke, J. Todd Blankenship, Prajal H. Patel
Vps54 is a subunit of the Golgi-associated retrograde protein (GARP) complex, which is involved in tethering endosome-derived vesicles to thetrans-Golgi network (TGN). In the wobbler mouse, a model for human motor neuron (MN) disease, reduction in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a7337da9e355afe9022c93d56d4f125
Autor:
Colin J. Jackson, Geoffrey D. Findlay, Adam M. Damry, Prajal H. Patel, Andreas Lange, Erich Bornberg-Bauer, Brennen Heames, Thorsten Saenger
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Comparative genomic studies have repeatedly shown that new protein-coding genes can emerge de novo from noncoding DNA. Still unknown is how and when the structures of encoded de novo proteins emerge and evolve. Combining biochemical, genetic and evol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0439314cc84bd73ae751fdd610c17f6d
https://pubmed.ncbi.nlm.nih.gov/33712569
https://pubmed.ncbi.nlm.nih.gov/33712569
Unlike many genes that arise from duplication, de novo evolved genes arise from previously noncoding DNA. Many de novo genes are expressed in the male reproductive tract, but their functions remain uncharacterized. We used an RNAi screen to identify
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e44434f28b832832d905c35df3fea19
Publikováno v:
The Journal of Cell Biology
Hypusination is a unique posttranslational modification by which lysine is transformed into the atypical amino acid hypusine. eIF5A (eukaryotic initiation factor 5A) is the only known protein to contain hypusine. In this study, we describe the identi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbe69a04e8f83905d082d5b97865df44
http://europepmc.org/articles/PMC2712966
http://europepmc.org/articles/PMC2712966
Autor:
Gerald M. Rubin, Trudy F. C. Mackay, Prajal H. Patel, Koenraad Norga, Roger A. Hoskins, Richard F. Lyman, Marjorie C. Gurganus, Akihiko Yamamoto, Christy L. Dilda, Hugo J. Bellen
Publikováno v:
Current Biology. 13(16):1388-1396
Background: The identification of the function of all genes that contribute to specific biological processes and complex traits is one of the major challenges in the postgenomic era. One approach is to employ forward genetic screens in genetically tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb7f1f47469c79f35340f7d64c25a978