Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Prajakta Deshpande"'
Autor:
Prajakta Deshpande, Chao-Yi Chen, Anuradha Venkatakrishnan Chimata, Jian-Chiuan Li, Ankita Sarkar, Catherine Yeates, Chun-Hong Chen, Madhuri Kango-Singh, Amit Singh
Publikováno v:
Cell Death and Disease, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Alzheimer’s disease (AD), an age-related progressive neurodegenerative disorder, exhibits reduced cognitive function with no cure to date. One of the reasons for AD is the accumulation of Amyloid-beta 42 (Aβ42) plaque(s) that trigger aber
Externí odkaz:
https://doaj.org/article/4b6bf2e90d494d1f8da8e9eec3dfcfd8
Autor:
Aditi Singh, Anuradha Venkatakrishnan Chimata, Prajakta Deshpande, Soumya Bajpai, Anjali Sangeeth, Mrigendra Rajput, Amit Singh
Publikováno v:
Neural Regeneration Research, Vol 19, Iss 6, Pp 1385-1392 (2024)
[INLINE:1] Infection caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) virus, responsible for the coronavirus disease 2019 (COVID-19) pandemic, induces symptoms including increased inflammatory response, severe acute respirato
Externí odkaz:
https://doaj.org/article/4de3b2b16e7b4383a814e0aecdea656b
Autor:
Prajakta Deshpande, Anuradha Venkatakrishnan Chimata, Emily Snider, Aditi Singh, Madhuri Kango-Singh, Amit Singh
Publikováno v:
Cell Death and Disease, Vol 14, Iss 7, Pp 1-18 (2023)
Abstract Alzheimer’s disease (AD), a progressive neurodegenerative disorder, manifests as accumulation of amyloid-beta-42 (Aβ42) plaques and intracellular accumulation of neurofibrillary tangles (NFTs) that results in microtubule destabilization.
Externí odkaz:
https://doaj.org/article/f044a166688745f3a711eb960b4db4b0
Publikováno v:
Neural Regeneration Research, Vol 18, Iss 4, Pp 784-789 (2023)
The pathology of Alzheimer’s disease involves a long preclinical period, where the characteristic clinical symptoms of the changes in the brain are undetectable. During the preclinical period, homeostatic mechanisms may help prevent widespread cell
Externí odkaz:
https://doaj.org/article/f18c4884c190404aa3356436fd4a8c6b
Publikováno v:
BioTechniques, Vol 71, Iss 2, Pp 416-424 (2021)
Numerous imaging modules are utilized to study changes that occur during cellular processes. Besides qualitative (immunohistochemical) or semiquantitative (Western blot) approaches, direct quantitation method(s) for detecting and analyzing signal int
Externí odkaz:
https://doaj.org/article/a917455e3be9428da7af1faafd8620f5
Publikováno v:
Neural Regeneration Research, Vol 16, Iss 4, Pp 643-652 (2021)
During development, regulation of organ size requires a balance between cell proliferation, growth and cell death. Dysregulation of these fundamental processes can cause a variety of diseases. Excessive cell proliferation results in cancer whereas ex
Externí odkaz:
https://doaj.org/article/d0e89dda60d74797a37f6cc28437a6c6
Publikováno v:
STAR Protocols, Vol 3, Iss 1, Pp 101140- (2022)
Summary: Cell death maintains tissue homeostasis by eliminating dispensable cells. Misregulation of cell death is seen in diseases like cancer, neurodegeneration, etc. Therefore, cell death assays like TUNEL have become reliable tools, where fragment
Externí odkaz:
https://doaj.org/article/46163768183644bb8b6203f4f5630a3e
Autor:
Abijeet Singh Mehta, Prajakta Deshpande, Anuradha Venkatakrishnan Chimata, Panagiotis A. Tsonis, Amit Singh
Publikováno v:
iScience, Vol 24, Iss 10, Pp 103166- (2021)
Summary: Newts utilize their unique genes to restore missing parts by strategic regulation of conserved signaling pathways. Lack of genetic tools poses challenges to determine the function of such genes. Therefore, we used the Drosophila eye model to
Externí odkaz:
https://doaj.org/article/a259047234e242faa1a81c4343464d25
Publikováno v:
iScience, Vol 23, Iss 12, Pp 101823- (2020)
Summary: To understand the progression of Alzheimer's disease, studies often rely on ectopic expression of amyloid-beta 42 (Aβ42) throughout an entire tissue. Uniform ectopic expression of Aβ42 may obscure cell-cell interactions that contribute to
Externí odkaz:
https://doaj.org/article/d01fb0cf2d6a41289816f9b1fbb2ba2f
Autor:
Neha Gogia, Ankita Sarkar, Abijeet Singh Mehta, Ph.D., Nandini Ramesh, Prajakta Deshpande, Madhuri Kango-Singh, Udai Bhan Pandey, Amit Singh
Publikováno v:
Neurobiology of Disease, Vol 140, Iss , Pp 104837- (2020)
Amyotrophic Lateral Sclerosis (ALS), a late-onset neurodegenerative disorder characterized by the loss of motor neurons in the central nervous system, has no known cure to-date. Disease causing mutations in human Fused in Sarcoma (FUS) leads to aggre
Externí odkaz:
https://doaj.org/article/a084db8a7dd045d384d9f88084881d68