Optimal CD8 + T‐cell memory formation following subcutaneous cytomegalovirus infection requires virus replication but not early dendritic cell responses

Autor: Ian R. Humphreys, Morgan Marsden, Pragati Sabberwal, Mathew Clement, Lucy Chapman, Sandra Dimonte, Silvia Gimeno-Brias

Publikováno v: Immunology

Summary Cytomegalovirus (CMV) induction of large frequencies of highly functional memory T cells has attracted much interest in the utility of CMV‐based vaccine vectors, with exciting preclinical data obtained in models of infectious diseases and c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::142dbc00bfba33cd609bd1011f7889ea
https://doi.org/10.1111/imm.13368

SARS-CoV-2 host-shutoff impacts innate NK cell functions, but antibody-dependent NK activity is strongly activated through non-spike antibodies

Autor: Ceri Alan Fielding, Pragati Sabberwal, James C Williamson, Edward JD Greenwood, Thomas WM Crozier, Wioleta Zelek, Jeffrey Seow, Carl Graham, Isabella Huettner, Jonathan D Edgeworth, David A Price, Paul B Morgan, Kristin Ladell, Matthias Eberl, Ian R Humphreys, Blair Merrick, Katie Doores, Sam J Wilson, Paul J Lehner, Eddie CY Wang, Richard J Stanton

Publikováno v: eLife. 11

Funder: Ser Cymru
The outcome of infection is dependent on the ability of viruses to manipulate the infected cell to evade immunity, and the ability of the immune response to overcome this evasion. Understanding this process is key to understand

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19f3328bcaee2680b348c255d1049925
https://pubmed.ncbi.nlm.nih.gov/35587364

Neutrophilia, lymphopenia and myeloid dysfunction: a living review of the quantitative changes to innate and adaptive immune cells which define COVID-19 pathology

Autor: Tehmina Bharuchq, Bruce MacLachlan, Ceri Fielding, Adrian L Smith, Fadi Issa, Emily Thornton, Raphael Sanches Peres, Calliope A Dendrou, Dorothée L Berthold, Liliana Cifuentes, Alicia Teijeira Crespo, Elizabeth H Mann, Arvind Sami, Anne Chauveau, Dominic S Alonzi, Anís Gammage, Fabian Fischer, Valentina M T Bart, Fangfang Lu, Miriam O'Hanlon, Lynn B Dustin, Pragati Sabberwal, Ewoud B. Compeer, Mariana Borsa, Rowie Borst, Hannah Almuttaqi, David J Ahern, Eleanor J Pring, Emma Jones, Ester Gea-Mallorquí, Kate Liddiard, Dingxi Zhou, Amy Cross, Sara Danielli, Max Quastel, Shayda Maleki-Toyserkani, Owen R Moon, Ruban Rex Peter Durairaj, Vicky Batchelor, Barbora Schonfeldova, Angus K T Wann, Lorenzo Capitani, Petros Ligoxygakis, Sandra Dimonte, Clara Eléonore Pavillet, Lion F K Uhl, Luke C Davies, Kristin Ladell, Stephanie Jean Hanna, Felix Richter, Freya R Shepherd, Sarah Hulin-Curtis, Stephanie Burnell, Amy Susan Codd, Anita Milicic, Quentin Sattentau, Juliane Brun, David Oliver Scourfield, Sophie Reed, Jan Rehwinkel, Ghada Alsaleh, D Oliver Scourfield, Michael Tellier, Reginald James Matthews, Eleanor Pring, Emma Mitchell, Anna Katharina Simon, Joseph D Wilson, Niamh Richmond, Van Dien Nguyen, Sarah N Lauder, Zihan Zhu, Tharini A Selvakumar, Ana Pires, Cariad Shorten, Richard Williams, Erinke van Grinsven, Sarah Galloway, Aljawharah Alrubayyi, Stephanie J. Hanna, Felix Clemens Richter, Julie M Mazet, Dimitra Peppa, Clarissa Coveney, Awen Gallimore, Cornelia Heuberger, Owen Moon, Ruth Jones, Helene Borrmann, Arthur Dyer, Lucy Chapman, Jelena S Bezbradica, Andrew Godkin, Rebecca Bayliss, Amy S. Codd, Anna M Marzeda, Athena Cavounidis, Patrícia R S Rodrigues, Alice J B Robinson, Ewoud Bernardus Compeer

Publikováno v: Oxford Open Immunology

Destabilization of balanced immune cell numbers and frequencies is a common feature of viral infections. This occurs due to, and further enhances, viral immune evasion and survival. Since the discovery of the Severe Acute Respiratory Syndrome coronav

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b44a2a9d86eac6ea736510e7a102f26e
https://doi.org/10.1093/oxfimm/iqab016