Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Pragati Kushwaha"'
Autor:
Ashish Kumar Tripathi, Divya Rai, Priyanka Kothari, Pragati Kushwaha, Koneni V. Sashidhara, Ritu Trivedi
Publikováno v:
Apoptosis
Glucocorticoid induced osteoporosis (GIOP) is the second most leading cause of osteoporosis. We have identified a compound, a benzofuran pyran hybrid compound 4e that has osteogenic potential and we wanted to assess its efficacy in GIOP in male mice.
Autor:
Divya Rai, Koneni V. Sashidhara, Ritu Trivedi, Shradha Sinha, Priyanka Kothari, Ashish Kumar Tripathi, Pragati Kushwaha, Anirban Sardar
Publikováno v:
Toxicology in vitro : an international journal published in association with BIBRA. 66
Obesity and ageing increases bone marrow fat which in turn is associated with lower bone mass. Marrow adipocytes by secreting cytokines, adipokines and free fatty acids change the bone marrow milieu and thus the number of osteoblasts. Palmitate is th
Autor:
Keerti Rawat, Prashant Khare, Shikha Mishra, Ram K. Modukuri, Ambak Kumar Rai, Sumit Joshi, Pragati Kushwaha, Anuradha Dube, K. Bhaskara Rao, Koneni V. Sashidhara, Anil K. Jaiswal
Publikováno v:
International Journal of Antimicrobial Agents. 48:695-702
Green fluorescent protein produces significant fluorescence and is extremely stable, however its excitation maximum is close to the ultraviolet range and thus can damage living cells. Hence, Leishmania donovani stably expressing DsRed were developed
Autor:
Naveen Parmar, Muhammad Wahajuddin, Sampa Gupta, Susanta Kar, Akanksha Upadhyay, Pragati Kushwaha, Pragya Chandrakar, Mamunur Rashid, Koneni V. Sashidhara, Sandeep Kumar Singh
Publikováno v:
Journal of medicinal chemistry. 62(11)
In our efforts to identify novel chemical scaffolds for the development of antileishmanial agents, a series of quinoline-metronidazole hybrid compounds was synthesized and tested against the murine model of visceral leishmaniasis. Among all synthesiz
Autor:
Mohammad Imran Siddiqi, Vikash Kumar, Hardik Chandasana, Pragati Kushwaha, Manish Kumar Suthar, Jitendra Kumar Saxena, Ram K. Modukuri, Ravi Sonkar, Rabi Sankar Bhatta, Yashpal S. Chhonker, K. Bhaskara Rao, Gitika Bhatia, A.K. Khanna, Koneni V. Sashidhara
Publikováno v:
MedChemComm. 7:1858-1869
In this study, a series of coumarin–indole hybrids have been synthesized and evaluated for their lipid lowering activity. Preliminary biological screening of the synthesized compounds was undertaken in an in vitro model of the HMG-CoA reductase enz
Autor:
Akanksha Upadhyay, Vikash Chandra Tripathi, Sneha Raj, L. Ravithej Singh, Anoop Kumar, Koneni V. Sashidhara, Mukesh Pasupuleti, Jesu Arockiaraj, Pragati Kushwaha, Soyar Horam, Sampa Gupta
Publikováno v:
Drug development research. 79(8)
Hit, Lead & Candidate Discovery Drug repurposing has become a recent trend in drug development programs, where previously developed drugs are explored for hit and redeveloped into potential therapeutic agents for new diseases. Globally, in any drug d
Autor:
Akanksha Upadhyay, Mohd Imran Siddiqi, Pragati Kushwaha, Sudha Bhagwati, Sampa Gupta, Tanvi Baghel, Soobiya Fatima, Koneni V. Sashidhara, Aamir Nazir
Publikováno v:
Bioorganicmedicinal chemistry letters. 29(1)
A series of novel Benzofuran-tetrazole derivatives were successfully synthesised by integrating multicomponent Ugi-azide reaction with the molecular hybridization approach. Interestingly, a number of synthesized derivatives (5c, 5d, 5i, 5l, 5q and 5s
Autor:
Naseer Ahmad, Priyanka Kothari, Akanksha Upadhyay, Ashish Kumar Tripathi, Tanuj Sharma, Pragati Kushwaha, Koneni V. Sashidhara, Ritu Trivedi, Mohammad Imran Siddiqi, Sampa Gupta
Publikováno v:
European journal of medicinal chemistry. 156
Twenty-four novel benzofuran-pyran derivatives were synthesized and evaluated for their anti-osteoporotic activity in primary cultures of rat calvarial osteoblasts in vitro. Among all the compounds screened for the alkaline phosphatase activity, thre
Autor:
Karthik Ramalingam, Akanksha Upadhyay, Koneni V. Sashidhara, Neena Goyal, Sampa Gupta, Pragati Kushwaha, Ranga Prasad Dodda, Ruchir Kant
Publikováno v:
European journal of medicinal chemistry. 154
The high potential of quinoline containing natural products and their derivatives in medicinal chemistry led us to discover novel series of 25 compounds for the development of new antileishmanial agents. A series of triazolyl 2-methyl-4-phenylquinoli
Autor:
Mohammad Imran Siddiqi, Dibyendu Banerjee, Sanjay Krishna, Akanksha Upadhyay, Sampa Gupta, Pragati Kushwaha, Koneni V. Sashidhara, Pooja Maurya
Publikováno v:
European journal of medicinal chemistry. 143
DNA replication and repair are complex processes accomplished by the concerted action of a network of enzymes and proteins. DNA ligases play a crucial role in these processes by catalyzing the nick joining between DNA strands. As compared to normal c