Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Prafulla, Aryal"'
Autor:
Conor McClenaghan, Alexandra Mackenzie, Y.Y. Dong, N.A. Burgess-Brown, A. Quigley, Gian Filippo Ruda, Lishuang Cao, Michael V. Clausen, L. Dong, Prafulla Aryal, S. Goubin, Stephen J. Tucker, Shubhashish M.M. Mukhopadhyay, Mark S.P. Sansom, Elisabeth P. Carpenter, Mariana Grieben, Ashley C. W. Pike, Paul Brennan
A sensitive regulator of cellular potassium A class of potassium channels called K2P channels modulates resting membrane potential in most cells. The channels are regulated by multiple ligands, including the antidepressant drug Prozac, as well as fac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ff00a48d4ce518c6ebb694b50186d46
https://doi.org/10.1126/science.1261512
https://doi.org/10.1126/science.1261512
Autor:
Agnese Baronina, Chady Nasrallah, George Hedger, Elisabeth P. Carpenter, Mariana Grieben, Jiye Shi, Qinrui Wang, Robin A. Corey, Prafulla Aryal, Ashley C. W. Pike, Mark S.P. Sansom
Publikováno v:
Structure(London, England:1993)
Summary Polycystin-2 (PC2) is a transient receptor potential (TRP) channel present in ciliary membranes of the kidney. PC2 shares a transmembrane fold with other TRP channels, in addition to an extracellular domain found in TRPP and TRPML channels. U
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c4897dab5028aa94cc5be15dcca5f89
https://doi.org/10.1016/j.str.2019.11.005
https://doi.org/10.1016/j.str.2019.11.005
Autor:
Mark S.P. Sansom, Prafulla Aryal, Ashley C. W. Pike, George Hedger, Jiye Shi, Elisabeth P. Carpenter, Mariana Grieben, Qinrui Wang
Publikováno v:
Biophysical Journal. 116:534a-535a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2daa2c02c9dc6a2949d8416605d0a3e
https://doi.org/10.1016/j.bpj.2018.11.2877
https://doi.org/10.1016/j.bpj.2018.11.2877
Publikováno v:
Biophysical Journal. 116:35a-36a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ae9860e81ddb7dcccee5b909c216881
https://doi.org/10.1016/j.bpj.2018.11.236
https://doi.org/10.1016/j.bpj.2018.11.236
Publikováno v:
Biochemical Society Transactions. 43:146-150
Gating in channels and nanopores plays a key role in regulating flow of ions across membranes. Molecular simulations provide a ‘computational microscope’ which enables us to examine the physical nature of gating mechanisms at the level of the sin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cab1675178e9e2f88c0c3741ecb4d914
https://doi.org/10.1042/bst20140256
https://doi.org/10.1042/bst20140256
Publikováno v:
Journal of Molecular Biology. 427:121-130
Biological ion channels are nanoscale transmembrane pores. When water and ions are enclosed within the narrow confines of a sub-nanometer hydrophobic pore, they exhibit behavior not evident from macroscopic descriptions. At this nanoscopic level, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58284bbbca6eecf92934a16836deecb1
https://doi.org/10.1016/j.jmb.2014.07.030
https://doi.org/10.1016/j.jmb.2014.07.030
Autor:
Prafulla, Aryal, Viwan, Jarerattanachat, Michael V, Clausen, Marcus, Schewe, Conor, McClenaghan, Liam, Argent, Linus J, Conrad, Yin Y, Dong, Ashley C W, Pike, Elisabeth P, Carpenter, Thomas, Baukrowitz, Mark S P, Sansom, Stephen J, Tucker
Publikováno v:
Structure(London, England:1993)
Summary The mechanosensitive two-pore domain (K2P) K+ channels (TREK-1, TREK-2, and TRAAK) are important for mechanical and thermal nociception. However, the mechanisms underlying their gating by membrane stretch remain controversial. Here we use mol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e4e886623574c09f130d2953d4ca83c0
https://pubmed.ncbi.nlm.nih.gov/28392258
https://pubmed.ncbi.nlm.nih.gov/28392258
Autor:
Stephen J. Tucker, Thomas Baukrowitz, Marcus Schewe, Prafulla Aryal, Elisabeth P. Carpenter, Conor McClenaghan
Publikováno v:
The Journal of General Physiology
TREK channels, which are gated open by a wide range of stimuli, exist in at least two conformations known as “up” and “down.” McClenaghan et al. show that the channel can be open in both of these conformations and that gating is primarily ach
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1e55742c094c41846e3e48eb15cc9e9
http://ora.ox.ac.uk/objects/uuid:e96e673e-61b8-41ce-a8e1-89d7b15c02e8
http://ora.ox.ac.uk/objects/uuid:e96e673e-61b8-41ce-a8e1-89d7b15c02e8
Publikováno v:
Biophysical Journal. 110(3)
Mammalian mechanosensitive ion channels are molecular sensors that transduce mechanical stimulus into altered electrical activity of cells. They are involved in numerous physiological processes such as touch, hearing, and cell growth. Recently, cryst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f3c23298067c8448c929b07e4c37ed3
Autor:
Bertha Dominguez, Brian K. Kaspar, Ronald W. Oppenheim, Yoshie Sugiura, Prafulla Aryal, Thomas W. Gould, Weichun Lin, Kuo-Fen Lee, Mark E. Hester, Mahru C. An, Chien-Ping Ko, Jiefei Yang, Daniel Padgett
Publikováno v:
Proceedings of the National Academy of Sciences. 107:10702-10707
Emerging evidence suggests that the neurotransmitter acetylcholine (ACh) negatively regulates the development of the neuromuscular junction, but it is not clear if ACh exerts its effects exclusively through muscle ACh receptors (AChRs). Here, we used
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30d023bc044f798223aa06b0818dac9b
https://doi.org/10.1073/pnas.1004956107
https://doi.org/10.1073/pnas.1004956107