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pro vyhledávání: '"Praful Lalan"'
The mechanism of formation of 6-Aryl-4,6-dioxohexanoic acids from arylketones and succinic anhydride
Publikováno v:
Tetrahedron Letters. 34:5189-5192
Compounds 2a-d could be synthesized directly from the requisite acetophenone enolate and succinic anhydride. Intermediate O-acylated products 1a-d were observed. Compounds 1a-d could be converted to 2a-d by treatment with at least two additional equi
Autor:
Patricia A. McDonnell, Diane Gauthier, Jacqueline C. Bussolari, Kimberly Beers, William V. Murray, Praful Lalan
Publikováno v:
ChemInform. 29
Aldol reactions of chiral aminoaldehydes and methylacrylate in the presence of 1,4-diazabicyclo[2.2.2]octane (DABCO) produces β-hydroxy methylbutenoates which can be utilized as psuedodipeptides. However, reaction of aminoaldehydes with acrylamide i
Publikováno v:
Pharmaceutical Research. :1386-1393
A peptide mapping procedure was developed to locate regions of a monoclonal antibody, OKT3, that undergo chemical modification as the molecule degrades upon storage. The structures of these peptide degradation products were investigated. Deamidation
Autor:
Patricia A. McDonnell, Kimberly Beers, Jacqueline C. Bussolari, William V. Murray, Praful Lalan, Diane Gauthier
Publikováno v:
Chemistry Letters. 27:787-788
Aldol reactions of chiral aminoaldehydes and methylacrylate in the presence of 1,4-diazabicyclo[2.2.2]octane (DABCO) produces β-hydroxy methylbutenoates which can be utilized as psuedodipeptides. However, reaction of aminoaldehydes with acrylamide i