Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Praful Aggarwal"'
Autor:
Marguerite R. Irvin, Praful Aggarwal, Steven A. Claas, Lisa de las Fuentes, Anh N. Do, C. Charles Gu, Andrea Matter, Benjamin S. Olson, Amit Patki, Karen Schwander, Joshua D. Smith, Vinodh Srinivasasainagendra, Hemant K. Tiwari, Amy J. Turner, Deborah A. Nickerson, Dabeeru C. Rao, Ulrich Broeckel, Donna K. Arnett
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Background: Indices of left ventricular (LV) structure and geometry represent useful intermediate phenotypes related to LV hypertrophy (LVH), a predictor of cardiovascular (CV) disease (CVD) outcomes.Methods and Results: We conducted an exome-wide as
Externí odkaz:
https://doaj.org/article/0344524737714338964b8b800f9381b8
Autor:
Mei Yu, Yuhong Chen, Hu Zeng, Yongwei Zheng, Guoping Fu, Wen Zhu, Ulrich Broeckel, Praful Aggarwal, Amy Turner, Geoffrey Neale, Cliff Guy, Nan Zhu, Hongbo Chi, Renren Wen, Demin Wang
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-18 (2017)
IL-7R activation drives early B cell development, but the signalling is unclear. Here the authors show PLCγ is involved in IL-7R-induced mTOR activation via a DAG/PKC-dependent pathway, and that double deficiency of the two PLCγ isoforms arrests B
Externí odkaz:
https://doaj.org/article/c452dfc952154a9d82178c4541f18fa3
Autor:
Praful Aggarwal, Amy Turner, Andrea Matter, Steven J Kattman, Alexander Stoddard, Rachel Lorier, Bradley J Swanson, Donna K Arnett, Ulrich Broeckel
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e108051 (2014)
Cardiac hypertrophy is an independent risk factor for cardiovascular disease and heart failure. There is increasing evidence that microRNAs (miRNAs) play an important role in the regulation of messenger RNA (mRNA) and the pathogenesis of various card
Externí odkaz:
https://doaj.org/article/3e02f43e09874765b076cda38947c497
Autor:
Mary V. Relling, Erin C. Boone, Cyrine-Eliana Haidar, Ulrich Broeckel, Praful Aggarwal, Andrea Gaedigk, Amy Turner, Ashley D. Derezinski
Publikováno v:
J Mol Diagn
Cytochrome P450 2D6 (CYP2D6) copy number (CN) variation affects the metabolism of numerous prescribed drugs. Sequence variation within primer or probe target regions of hydrolysis probe CN assays can generate false-positive calls for CN loss. Further
Autor:
Ulrich Broeckel, Benjamin Olson, Donna K. Arnett, C. Charles Gu, Praful Aggarwal, Rachel Lorier, Steven C. Hunt, Andrea Matter, Cora E. Lewis, Amy Turner
Publikováno v:
Am J Physiol Heart Circ Physiol
Exosomes are an important mechanism of cell-cell interaction in the cardiovascular system, both in maintaining homeostasis and in stress response. Interindividual differences that alter content in exosomes may play a role in cardiovascular disease pa
Autor:
Rebecca S. LaRue, Louisa E. Sjaastad, Mark S. Anderson, Calvin B. Williams, Praful Aggarwal, Maria-Luisa Alegre, Ulrich Broeckel, Shawn A. Mahmud, Irina Proekt, Dimitre R. Simeonov, Jason B. Williams, Michael A. Farrar, Weishan Huang, Jonathan C. Jeschke, Corey N. Miller, Roland Ruscher, David L. Owen, Christine Henzler, Justin A. Spanier, Can Hekim, Avery August, Alexander Marson, Ye Zheng
Publikováno v:
Nature immunology
The developmental programs that generate a broad repertoire of regulatory T cells (Treg cells) able to respond to both self antigens and non-self antigens remain unclear. Here we found that mature Treg cells were generated through two distinct develo
Autor:
Karen Schwander, Steven A. Claas, Ulrich Broeckel, Benjamin Olson, Andrea Matter, Vinodh Srinivasasainagendra, Joshua D. Smith, Praful Aggarwal, Hemant K. Tiwari, Deborah A. Nickerson, Marguerite R. Irvin, Amit Patki, Lisa de las Fuentes, Anh N. Do, C. Charles Gu, Donna K. Arnett, Amy Turner, Dabeeru C. Rao
Publikováno v:
Frontiers in Genetics
Frontiers in Genetics, Vol 12 (2021)
Frontiers in Genetics, Vol 12 (2021)
Background: Indices of left ventricular (LV) structure and geometry represent useful intermediate phenotypes related to LV hypertrophy (LVH), a predictor of cardiovascular (CV) disease (CVD) outcomes.Methods and Results: We conducted an exome-wide as
Autor:
Andrea, Gaedigk, Amy, Turner, Robin E, Everts, Stuart A, Scott, Praful, Aggarwal, Ulrich, Broeckel, Gwendolyn A, McMillin, Roberta, Melis, Erin C, Boone, Victoria M, Pratt, Lisa V, Kalman
Publikováno v:
J Mol Diagn
Pharmacogenetic testing increasingly is available from clinical and research laboratories. However, only a limited number of quality control and other reference materials currently are available for the complex rearrangements and rare variants that o
Autor:
Ulrich Broeckel, Amy Turner, Praful Aggarwal, Andrea Matter, Benjamin Olson, Matthew T. White
Publikováno v:
Circulation. 138
Small molecule tyrosine kinase inhibitors (TKIs) are a valuable class of therapeutics with widespread clinical utility against multiple cancers. However, there is strong evidence that TKIs are associated with cardiotoxicity and adverse cardiovascular
Autor:
Paul Hujsak, Amy Turner, Ruth Epstein-Baak, Ruth Kornreich, Ulrich Broeckel, Lorraine Toji, Robin E. Everts, Brittany N. Beyer, Jun Liao, Stuart A. Scott, Rachel Lorier, Praful Aggarwal, Chingying Huang Smith, Victoria M. Pratt, Lisa V. Kalman
Publikováno v:
The Journal of Molecular Diagnostics. 18:109-123
Pharmacogenetic testing is increasingly available from clinical laboratories. However, only a limited number of quality control and other reference materials are currently available to support clinical testing. To address this need, the Centers for D