Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Pradyot Dash"'
Autor:
Dina Schneider, Bal Krishna Chand Thakuri, Saule Nurmukhambetova, Brittany Steimle, Peirong Hu, Pradyot Dash, Jia-Jye Lee, Tri Minh Tran, Ngoc Q Tran
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 4 (2024)
Background Chimeric antigen receptor (CAR) T-cell therapy target receptor tyrosine kinase-like orphan receptor 1 (ROR1) is broadly expressed in hematologic and solid tumors, however clinically-characterized ROR1-CAR T cells with single chain variable
Externí odkaz:
https://doaj.org/article/2594229ecd7a4d1abcd6fb73370fb956
Autor:
Leah M. Alabanza, Ying Xiong, Bang Vu, Brian Webster, Darong Wu, Peirong Hu, Zhongyu Zhu, Boro Dropulic, Pradyot Dash, Dina Schneider
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
CAR T-cell therapies targeting the B-cell maturation antigen eliminate tumors in relapsed/refractory multiple myeloma patients, however durable remissions remain difficult to attain. Transforming growth factor beta (TGF-β) is a multifunctional cytok
Externí odkaz:
https://doaj.org/article/563982a5fba847dc87ba9da1690fc72e
Autor:
Sherri L. Surman, Jeremy Crawford, Pradyot Dash, Susan L. Tonkonogy, Paul G. Thomas, Julia L. Hurwitz
Publikováno v:
Biomedicines, Vol 10, Iss 12, p 3015 (2022)
The microbiome shapes the mature T cell receptor (TCR) repertoire and thereby influences pathogen control. To investigate microbiome influences on T cells at an earlier, immature stage, we compared single-cell TCR transcript sequences between CD4+CD8
Externí odkaz:
https://doaj.org/article/3dbbd2784b694163815998842583f0f1
Autor:
Sneha Sant, Misty R Jenkins, Pradyot Dash, Katherine A Watson, Zhongfang Wang, Angela Pizzolla, Marios Koutsakos, Thi HO Nguyen, Martha Lappas, Jane Crowe, Tom Loudovaris, Stuart I Mannering, Glen P Westall, Tom C Kotsimbos, Allen C Cheng, Linda Wakim, Peter C Doherty, Paul G Thomas, Liyen Loh, Katherine Kedzierska
Publikováno v:
Clinical & Translational Immunology, Vol 8, Iss 9, Pp n/a-n/a (2019)
Abstract Background Although γδ T cells comprise up to 10% of human peripheral blood T cells, questions remain regarding their role in disease states and T‐cell receptor (TCR) clonal expansions. We dissected anti‐viral functions of human γδ T
Externí odkaz:
https://doaj.org/article/7ff1b72faa64454082fb640c16d1ffe8
Autor:
Xi-zhi J Guo, Pradyot Dash, Matthew Calverley, Suzanne Tomchuck, Mari H Dallas, Paul G Thomas
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 3, Iss C (2016)
Transgenic expression of antigen-specific T-cell receptor (TCR) genes is a promising approach for immunotherapy against infectious diseases and cancers. A key to the efficient application of this approach is the rapid and specific isolation and cloni
Externí odkaz:
https://doaj.org/article/cfd14d739a994cc4bc469b9335509cc8
Autor:
Peter S Askovich, Catherine J Sanders, Carrie M Rosenberger, Alan H Diercks, Pradyot Dash, Garnet Navarro, Peter Vogel, Peter C Doherty, Paul G Thomas, Alan Aderem
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e74863 (2013)
Influenza viruses exhibit large, strain-dependent differences in pathogenicity in mammalian hosts. Although the characteristics of severe disease, including uncontrolled viral replication, infection of the lower airway, and highly inflammatory cytoki
Externí odkaz:
https://doaj.org/article/5bc740ec4e6746ab9ad663948e88c2ba
Autor:
Tracy J Ruckwardt, Allison M W Malloy, Emma Gostick, David A Price, Pradyot Dash, Jennifer L McClaren, Paul G Thomas, Barney S Graham
Publikováno v:
PLoS Pathogens, Vol 7, Iss 12, p e1002377 (2011)
Following respiratory syncytial virus infection of adult CB6F1 hybrid mice, a predictable CD8+ T cell epitope hierarchy is established with a strongly dominant response to a K(d)-restricted peptide (SYIGSINNI) from the M2 protein. The response to K(d
Externí odkaz:
https://doaj.org/article/55ead976929548608b5098c3ade7544c
Autor:
Tri Tran, Bal Krishna Chand Thakuri, Saule Nurmukhambetova, Brittany Steimle, Ngoc Tran, Darong Wu, Peirong Hu, Pradyot Dash, Dina Schneider
Publikováno v:
Regular and Young Investigator Award Abstracts.
Publikováno v:
Regular and Young Investigator Award Abstracts.
Publikováno v:
Cancer Research. 83:3198-3198
Introduction: Despite significant progress in the chimeric antigen receptor (CAR)-T cell therapy of B cell malignancies, the 5-year progression-free survival rate in large B cell lymphoma following CD19-targeting CAR-T cell treatments remains below 5