Integrative systems immunology uncovers molecular networks of the cell cycle that stratify COVID-19 severity.

Autor: Prado CAS; Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil., Fonseca DLM; Interunit Postgraduate Program on Bioinformatics, Institute of Mathematics and Statistics (IME), University of Sao Paulo (USP), Sao Paulo, Brazil., Singh Y; Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil., Filgueiras IS; Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil., Baiocchi GC; Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil., Plaça DR; Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil., Marques AHC; Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil., Dantas-Komatsu RCS; Postgraduate Program in Health Sciences, Federal University of Rio Grande do Norte, Natal, Brazil., Usuda JN; Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil., Freire PP; Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil., Salgado RC; Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil., Napoleao SMDS; Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil., Ramos RN; Laboratory of Medical Investigation in Pathogenesis and Directed Therapy in Onco-Immuno-Hematology (LIM-31), Departament of Hematology and Cell Therapy, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, University of São Paulo, São Paulo, Brazil.; Instituto D'Or de Ensino e Pesquisa, Hospital São Luiz, São Paulo, Brazil., Rocha V; Laboratory of Medical Investigation in Pathogenesis and Directed Therapy in Onco-Immuno-Hematology (LIM-31), Departament of Hematology and Cell Therapy, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, University of São Paulo, São Paulo, Brazil.; Instituto D'Or de Ensino e Pesquisa, Hospital São Luiz, São Paulo, Brazil.; Fundação Pró-Sangue-Hemocentro de São Paulo, Hospital das Clínicas da Universidade de São Paulo, São Paulo, Brazil.; Department of Hematology, Churchill Hospital, University of Oxford, Oxford, UK., Zhou G; Institute of Parasitology, McGill University, Montreal, Quebec, Canada., Catar R; Department of Nephrology and Internal Intensive Care Medicine, Charité University Hospital, Berlin, Germany., Moll G; Department of Nephrology and Internal Intensive Care Medicine, Charité University Hospital, Berlin, Germany.; Berlin Institute of Health (BIH) and Berlin Center for Regenerative Therapies (BCRT), Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin-Brandenburg School for Regenerative Therapies (BSRT), all Charité Universitätsmedizin Berlin, Berlin, Germany., Camara NOS; Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil., de Miranda GC; Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil., Calich VLG; Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil., Giil LM; Department of Internal Medicine, Haraldsplass Deaconess Hospital, Bergen, Norway., Mishra N; Institute of Clinical Molecular Biology, Kiel University and University Medical Center Schleswig-Holstein, Kiel, Germany., Tran F; Institute of Clinical Molecular Biology, Kiel University and University Medical Center Schleswig-Holstein, Kiel, Germany.; Department of Internal Medicine I, University Medical Center Schleswig-Holstein, Kiel, Germany., Luchessi AD; Department of Clinical and Toxicology Analysis, Federal University of Rio Grande do Norte, Natal, Brazil., Nakaya HI; Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.; Instituto Israelita de Ensino e Pesquisa Albert Einstein, Hospital Israelita Albert Einstein, São Paulo, Brazil., Ochs HD; Department of Pediatrics, University of Washington School of Medicine and Seattle Children's Research Institute, Seattle, Washington, USA., Jurisica I; Osteoarthritis Research Program, Division of Orthopedic Surgery, Schroeder Arthritis Institute, UHN, Toronto, Ontario, Canada.; Institute of Neuroimmunology, Slovak Academy of Sciences, Bratislava, Slovakia.; Departments of Medical Biophysics and Computer Science, Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada.; Krembil Research Institute, UHN, Data Science Discovery Centre, Toronto, Ontario, Canada., Schimke LF; Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil., Cabral-Marques O; Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.; Interunit Postgraduate Program on Bioinformatics, Institute of Mathematics and Statistics (IME), University of Sao Paulo (USP), Sao Paulo, Brazil.; Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.; Department of Pharmacy and Postgraduate Program of Health and Science, Federal University of Rio Grande do Norte, Natal, Brazil.; Department of Medicine, Division of Molecular Medicine, University of São Paulo School of Medicine, São Paulo, Brazil.; Laboratory of Medical Investigation 29, University of São Paulo School of Medicine, São Paulo, Brazil.

Publikováno v: Journal of medical virology [J Med Virol] 2023 Feb; Vol. 95 (2), pp. e28450.