Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Pradip K. Sasmal"'
Autor:
Francesca Lazzara, Federica Conti, Pradip K. Sasmal, Shanavas Alikunju, Settimio Rossi, Filippo Drago, Chiara Bianca Maria Platania, Claudio Bucolo
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Diabetic retinopathy is a secondary microvascular complication of diabetes mellitus. This disease progresses from two stages, non-proliferative and proliferative diabetic retinopathy, the latter characterized by retinal abnormal angiogenesis. Pharmac
Externí odkaz:
https://doaj.org/article/a81b5eee337e4d13b952c91027a17ea8
Publikováno v:
Results in Chemistry, Vol 3, Iss , Pp 100173- (2021)
The expiry date of any medicine is decided based on the time span during which the drug product maintains its quality and is safe as well as effective. The levels of various impurities present in any drug product are considered safe based on various
Externí odkaz:
https://doaj.org/article/5d713c9f739e4298a26874d87a98adb9
Autor:
Jayoung Kim, Yongsheng Gao, Zongmin Zhao, Danika Rodrigues, Eden E. L. Tanner, Kelly Ibsen, Pradip K. Sasmal, Rajasekhar Jaladi, Shanavas Alikunju, Samir Mitragotri
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Apomorphine, a dopamine agonist, is a highly effective therapeutic to prevent intermittent off episodes in advanced Parkinson's disease. However, its short systemic half-life necessitates three injections per day. Such a frequent dosing regimen impos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86a78ad62d7b0f77f43b0e51b5989fd7
https://doi.org/10.1073/pnas.2110450119
https://doi.org/10.1073/pnas.2110450119
Autor:
K. C. Nicolaou, Pradip K. Sasmal, A. J. Roecker, Xiao-Wen Sun, Sunil Mandal, Antonella Converso
Publikováno v:
Angewandte Chemie. 117:3509-3513
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e28b226b67b8b0ea67ce9c33edf7780
https://doi.org/10.1002/ange.200500216
https://doi.org/10.1002/ange.200500216
Autor:
Anthony J. Roecker, Antonella Converso, Pradip K. Sasmal, Eriketi Z. Loizidou, Florian Kaiser, Goran Petrovic, Xiao-Wen Sun, Theocharis V. Koftis, Kyriacos C. Nicolaou, Constantinos C. Dellios
Publikováno v:
Angewandte Chemie International Edition. 44:3447-3452
The remarkable antifeedant agent and insecticide, azadirachtin (1), has, to date, escaped a total synthesis. The preparation of an advanced precursor has revealed some of the inner intricacies of this uniquely crowded and highly functionalized molecu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03a9bcd931f4f60bbe0ee418dc2c7bab
https://doi.org/10.1002/anie.200500217
https://doi.org/10.1002/anie.200500217
Publikováno v:
Journal of the American Chemical Society. 126:5493-5501
The total synthesis of 1-O-methyllateriflorone (2) is described. The construction of the cage-like domain of the molecule involved a biomimetic Claisen/Diels−Alder cascade, whereas the novel spiroxalactone framework was generated by an intramolecul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a72586af102b5bd9a2c008421acb1cf
https://doi.org/10.1021/ja040037+
https://doi.org/10.1021/ja040037+
Autor:
Andreas Ritzén, Aurora O'Brate, Kenji Namoto, Pradip K. Sasmal, Rubén M. Buey, José Manuel Andreu, Paraskevi Giannakakou, J. Fernando Díaz, Kyriacos C. Nicolaou
Publikováno v:
Chemistry & Biology. 11(2):225-236
The interactions of epothilone analogs with the paclitaxel binding site of microtubules were studied. The influence of chemical modifications in the C15 side chain and in C12 on binding affinity and microtubule elongation was characterized. Modificat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3a2977ff5995b2b654c3f6cd17a87f0
Autor:
Gerasimos A. Rassias, Karl-Heinz Altmann, Pradip K. Sasmal, Kyriacos C. Nicolaou, Paraskevi Giannakakou, Aurora O'Brate, Markus Wartmann, Mali V. Reddy
Publikováno v:
Angewandte Chemie International Edition. 42:3515-3520
Owing to their potent cytotoxicity against tumor cells, including taxol (paclitaxel)-resistant cell lines, the epothilones (for example, epothilone A (1) and epothilone B (2)) continue to be the focus of intense chemical, biological, and clinical res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90faa8ec1ec80da80f2614f285163fd0
https://doi.org/10.1002/anie.200351819
https://doi.org/10.1002/anie.200351819
Autor:
Martin E. Maier, Pradip K Sasmal
Publikováno v:
The Journal of Organic Chemistry. 68:824-831
A range of 2-deoxyfuranoside and -pyranoside derivatives were fashioned into derivatives that carry a vinyl or propenyl side chain. Extension of the alkene by a Suzuki cross-coupling reaction with 1-bromo-1-(phenylthio)ethene gave thioenol ethers as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e2ae2125dee67229c64440adfddd371
https://doi.org/10.1021/jo026163i
https://doi.org/10.1021/jo026163i
Publikováno v:
Organic Letters. 2:1325-1328
[formula: see text] Aldol reaction of tetrahydro-4H-thiopyran-4-one with racemic 1,4-dioxa-8-thiaspiro[4.5]decane-6-carboxaldehyde is easily controlled to give the 2,3-anti-3,4-syn or the 2,3-syn-3,4-syn adduct. Aldol homologations of these beta-hydr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b34b7733dbba6cc5bc7bd0d090262999
https://doi.org/10.1021/ol005790w
https://doi.org/10.1021/ol005790w